豚鼠

Results showed that L-THP possessed negative inotropic and negative chronotropic action, lowed left ventricular pressure and it's infinitesimal calculus, decreased heart output in per min., shorten 〓 and 〓 of action potential of ventricular papillary muscle of guinea pig and even the plate-phase of action potential disappeared in larger dose group , but prolonged 〓. we studied transmembrane transportation of 〓 after administering L-THP , L-THP not only depressed uptake and increased release of Ca 2+ in normal myocardium, but also it showed stronger inhibition in cell injured by ISO, and fully eliminated the effect of ISO increasing uptake and decreasing release of 〓. By detecting the 〓 content of ventricular single myocyte using fluorescent probe Fluo-3/AM, results correspond to that done above, L-THP decreased 〓 content inside of cell significantly. Using whole-cell mode, we observed the effect of L-THP on Ica in ventricular single cell, it was found that L-THP decreased Ica, the effect increased with increasing it's dose, and had voltage, frequency-dependency. Dose highly corelated to effect, corelative constant is 0.87. When washing cell with normal tyre's solution, Ica could recover, which proved the blocked action of L-THP on calcium channel once again. Meanwhile, L-THP reduced production of MDA in heart injured by ISO in dose-dependent manner, improved content of GSH-Px, in case tissue or cell free from free radical damage.

结果显示，该药物具有负性肌力和负性频率作用，降低左室压及其微分，终使每分心输出量减少；缩短豚鼠心室乳头肌动作电位时程的〓和APD〓，大剂量使动作电位平台消失，〓延长；同位素示踪法研究证实L-THP抑制〓摄取，促进〓释放，降低细胞内的〓含量；单通道水平的研究证实，L-THP减少豚鼠心室肌单细胞内向钙电流，且具有剂量，电压，频率依赖性，其作用易于洗脱，药物剂量与Ica也具有高度相关性（相关系数r为-0.87）；L-THP还可抑制ISO损伤心肌组织所致的丙二醛含量增加，增加谷胱甘肽过氧化物酶的量，使组织细胞免受损伤。L-THP阻断L-型〓通道，抑制〓的摄取，促进〓的释放，降低细胞内〓含量L-THP作用的离子基础。

The effect on pregnant guinea pig of cytomegalovirus infection through subcutanues and intracardiac was evaluated.

本实验观察了豚鼠巨细胞病毒感染对怀孕豚鼠的影响。从皮下和心腔接种病毒感染动物，接种病毒的时间在动物妊娠早期。

The dose-response curve of histamine was shifted parallely to the right. pA2 was 9.34±0.61. The guinea-pigs were effectively reduced the rate of histamine induced death, decreased reaction extent of shock (P＜0.01) and prolonged latency period of shock (P＜0.05) by orally administered cetirizine ranged from 0.1, 0.2 and 0.4 mg.kg-1. The capillary permeability to intracutaneous injection of histamine was potently inhibited by orally administered cetirizine ranged from 0.0625 to 0.25 mg.kg-1 in mice, blue area obviously decreased (P＜0.01), and dose-response curve existed obviously. In which the effect of these dosage groups were superior to the group of chlorphenamine.

结果：西替利嗪3×10-8～3×10-7mol.L-1可剂量依赖性地对抗组胺引起的肠肌收缩，使组胺的量效曲线平行右移，pA2为9.34 ± s 0.61，西替利嗪0.1，0.2及0.4 mg.kg-1口服给药时，能明显减轻豚鼠静脉注射组胺所致休克反应的严重程度(P＜0.01)，并可延长豚鼠惊厥反应的潜伏期及降低死亡率(P＜0.05)，西替利嗪0.0625～0.25 mg.kg-1口服给药可显著对抗组胺引起的小鼠皮肤血管通透性的增高，使蓝染面积显著缩小(P＜0.01)，且存在明显的量效关系，3个剂量组的作用均优于氯苯那敏组。

Methods The cardiocytes of adult guinea pigs were isolated and hypoxia models were set up,the effects of injected GSTT on the cellular membrane active potential and electricity flow of potassium channel were recorded with whole cell patchclamp system.

分离豚鼠心肌细胞，建立缺氧模型，分为正常对照组、模型组及GSTT10和30 mg·L-1组，采用全细胞膜片钳记录各组成年豚鼠单个心肌细胞的电位变化及测定钾通道电流。

These mutations greatly changed the level of protein synthesis, lipogenesis and JAK2 phosphorylation stimulated by GH, although they did not affect the expression of the GHR and ligand binding.

研究结果表明豚鼠GHR中的一些氨基酸残基的取代并不影响生长激素通过它而诱导的细胞事件，而另外一些氨基酸残基的取代，例如168位的酪氨酸和332位的丝氨酸分别用在其它种属GHR中高度保守的精氨酸和酪氨酸的取代后，则明显地影响着豚鼠GHR介导的GH诱导的生理效应。

MethodsModel cholelithiasis guinea pigs were established by special lithiasis diet, and 1% tea polyphenols was administrated in the low and high dosage group as sole drinking water for therapy .

方法用致石饲料建立豚鼠胆色素结石模型，用药组用1%的茶多酚作为唯一饮用水进行饲喂，比较各组豚鼠的成石率，并检测血脂、胆囊炎症、自由基的表达等指标。

Any of various long-eared and long-legged cavies of the genus Dolichotis, inhabiting the scrub desert and grasslands of central and southern Argentina.

巴塔哥尼亚野兔任一种生活在阿根廷中部和南部灌木沙漠和草原上豚鼠属的，生有长耳长腿的豚鼠

We use modiolus puncture approach shown by Alder to obtain recordings of discharge signals from single auditory nerve in guinea pig, and adopt digitally controlled system, which is designed on our self to generate complex waveforms, to measure properties of basic acoustically-evoked response of single auditory nerve.

实验在23只豚鼠上进行，运用Alder的蜗轴穿刺法，记录豚鼠听神经单纤维放电，并用自行研制的计算机程控复杂模式声刺激系统，测定听神经单纤维的基本声反应特性。

METHODS:Guinea-pigs were sensitized by ovalbumin and the effects of LMWH on the constriction of ileum smooth muscle induced by OA were observed in vitro;The effects of LMWH on the degranulation of pericranium mast cell induced by OA were observed throu gh the passive anaphylaxis ratmodel which was made by vaccinating antiserum at pericranium;Licking response was induced by 4-aminopyridine(4-AP) scat scruff in mice,then the effect of LMWH on licking response was studied the capillary p emeabilty increasing induced by glactal acetic acid and the effect of LMWH on ca pillary pemeability were studied.

用卵白蛋白(ovalbumin，OA)免疫豚鼠造成过敏模型，观察LMWH对OA所致的豚鼠离体回肠平滑肌收缩的影响；在大鼠颅骨骨膜接种抗血清使肥大细胞被动致敏，观察LMWH对OA引起肥大细胞脱颗粒的影响；以4-氨基吡啶诱发小鼠舔体反应，观察LMWH对舔体反应的影响；以冰醋酸使小鼠毛细血管通透性增加，观察LMWH对通透性的影响。

The ocular axis length and diopters were measured in all animals using A ultrasounder and retinoscopy.

结果 白化豚鼠存在高度近视，眼轴较长；有色豚鼠为低度远视，眼轴较短；二者差异有统计学意义(P.05)。

According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm～150rpm时取得最大值，此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世，形体几无变化。