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Although many results have been obtained, there are still a number of very interesting questions about composition operators unsolved. There is much more to be learned about the collective compactness and convergence of composition operator sequences, compactness of various product of composition operators, cyclicity, closed range and spectra of composition operators in various settings. Commutants of composition operators seem to be very difficult to characterize. Only a little is known about their reducing invariant subspaces. There has been no work on C〓 algebras generated by composition operators.

尽管已取得如此丰富的结果,但是关于复合算子仍然有大量非常有意义的问题值得研究,例如:复合算子序列的总体紧性及收敛性、复合算子的各种乘积的紧性、复合算子的闭值域问题、复合算子在各种解析函数空间上的谱的描述、换位复合算子的刻画、复合算子诱导的不变子空间问题、循环复合算子的研究、由复合算子生成的C〓-代数的研究、不同解析函数空间之间的加权复合算子及复合算子半群等等问题。

Oil film thickness along the piston skirt in motored engine was measured, and the comparison with theory result was given.

最后在实验研究中,本文国内首次在活塞裙部油膜厚度中采用了激光荧光诱导的测试方法,主要工作是:分析了激光荧光诱导法的基本原理,建立了测膜厚的基本定量关系模型,通过实验分析了膜厚测试的各种影响因素,通过实验对不同香豆素荧光光谱和激发光谱特性进行了分析,通过实验确定了选取香豆素的种类和溶液浓度的基本原则,自主开发了以光纤为光学光路的测试系统并对系统进行了标定,对内燃机冷拖动状态的活塞裙部进行了实测,并与理论测试结果进行了对比。

Features of AAD and inflammation were compared between uninfected or unsensitized controls.

结果显示,在感染后的10~15天,我们观察到,衣原体诱导的中等程度的肺部病变,通过增加细菌的数量、肺的组织病理学改变和体重的降低等而得到证实。6周后,感染情况和组织病理的改变得到缓解,体重增加的比率得到恢复。

That as from the beginning, a projection OF that form that assumed its position or condition in the earth as from the beginning, and with those so endowed with that as may be called an insight into psychic sources there may be visioned about a body its astral, rather its THOUGHT body, as is projected FROM same in such a state; especially so when there is the induction, or the inducing of, an unconsciousness of the normal brain, or normal mental body.

从开始的时候起,从开始的时候起假定它在地球上的位置或情形的形态的投射,由于赋予了可以被称作的内在精神本源,在本源里身体可以被想象成星形的,确切说就是思想体,同样可以以如此的一个状态来进行投射;特别在感应的时候,或一个正常的无意识大脑或正常的精神身体的进行意识诱导的时候。

Recently, it is found that the neuron apoptosis caused by brain ischemia is associated with signal pathway of endoplasmic reticulum stress, which is different from the traditional apoptotic pathway. Caspase-12 has been identified as a molecule which initiates apoptosis selectively in response to ER stress and is not activated by other pathways. Caspase-12 is localized on the ER membrane, but once specifically activated by ER stress, it translocates to the cytoplasm.

最近的研究发现,这种细胞凋亡与内质网应激(endoplasmic reticulum stress ER stress)有关,其是一种不同于经典的凋亡途径的新途径,分子伴侣葡萄糖调节蛋白78(glucose regulated protein, GRP78/Bip)表达增高是反应ER stress的最敏感的指标,胱冬酶-12(caspase-12)为鼠源性的内质网膜上的蛋白,它的特点是只被内质网诱导的凋亡所激活而不被其它非内质网因素所激活。

The results of its intrinsic fluorescence spectroscopy and fluorescence phase diagram showed that when the guanidine hydrochloride concentration in denaturation solution was about 1.0 mol/L, there existed a partially folded intermediate of Bacillus amyloliquefaciens a-amylase during its unfolding procedure, which followed a three-state model; the result of its fluorescence probe showed that when the guanidine hydrochloride concentration in denaturation solution was about 1.0 mol/L, there existed some stable hydrophobic regions, which could interact with a hydrophobic reagent 8-anilino-1-naphthalene sulfonic acid, in the partially folded intermediate of Bacillus amyloliquefaciens a-amylase; and the results of fluorescence quenching using acrylamide and potassium iodide as quenchers showed the distribution of Trp residues in Bacillus amyloliquefaciens a-amylase in different denaturation solution, with the maximum number (8) of tryptophan residues in a partially folded intermediate Bacillus amyloliquefaciens a-amylase molecule could be quenched by potassium iodide; and the results of their protein electrophoresis and SEC showed that no aggregate or aggregate precipitation of Bacillus amyloliquefaciens a-amylase formed during the whole unfolding procedure of Bacillus amyloliquefaciens a-amylase induced by guanidine hydrochloride.

内源荧光光谱和荧光相图结果表明,当变性液中盐酸胍浓度约为1.0 mol/L时,芽孢杆菌a-淀粉酶的去折叠过程中出现一个部分折叠中间体,其去折叠过程符合&三态模型&;荧光探针结果表明,在溶液中盐酸胍浓度约为1.0 mol/L时,中间态芽孢杆菌a-淀粉酶分子中存在着能够与探针分子1-苯胺基-8-萘磺酸结合的稳定的疏水区域;荧光猝灭研究给出了不同程度变性的淀粉液化芽孢杆菌a-淀粉酶中的Trp的分布情况,结果表明中间态芽孢杆菌a-淀粉酶分子中能够被碘化钾猝灭的位于分子表面的色氨酸残基数目达到最大的8个;蛋白电泳和体积排阻色谱结果表明,在盐酸胍诱导的芽孢杆菌a-淀粉酶分子的整个去折叠过程中,不会以共价键或非共价键形式形成芽孢杆菌a-淀粉酶分子之间的集聚体或集聚体沉淀。

The results of its fluorescence probe showed that when the guanidine hydrochloride concentration in denaturation solution was about 1.0 mol/L,there existed some stable hydrophobic regions,which could interact with a hydrophobic reagent 8-anilino-1-naphthalene sulfonic acid,in the partially folded intermediate of Bacillus amyloliquefaciensα-amylase;with the denaturation concentration increasing,the stable hydrophobic regions disappered.the results of fluorescence quenching using acrylamide and potassium iodide as quenchers showed that using acrylamide as quenchers,with the protein denaturation extent increasing,the number of Trp that can be quenched increased untill all the Trp residues were quenched;Using potassium iodide as quenchers,with the maximum number(8) of tryptophan residues in a partially folded intermediate Bacillus amyloliquefaciensα-amylase molecule could be quenched by potassium iodide;with the denaturation concentration increasing,the number of Trp that can be quenched decreased to 5.the results of their protein electrophoreses and SEC showed that no aggregate or aggregate precipitation of Bacillus amyloliquefaciensα-amylase formed during the whole unfolding/refolding procedure of Bacillus amyloliquefaciensα-amylase induced by guanidine hydrochloride or urea.

ANS外源荧光探针结果表明:盐酸胍诱导的芽孢杆菌α-淀粉酶分子去折叠过程中存在着能够与探针分子1-苯胺基-8-萘磺酸结合的稳定的疏水区域;而随着芽孢杆菌α-淀粉酶分子在盐酸胍溶液中变性程度的加深,这一疏水区域逐步被瓦解。丙烯酰胺和碘化钾猝灭结果表明:在盐酸胍溶液中,随着芽孢杆菌α-淀粉酶分子变性程度的进一步加深,其分子内能够被丙烯酰胺接近的色氨酸残基逐渐增多,直至全部被猝灭。但位于芽孢杆菌α-淀粉酶分子表面的能够被碘化钾猝灭的色氨酸残基,在中间态芽孢杆菌α-淀粉酶分子中数目达到最大的8个,而随着其分子变性程度的进一步加深,反而减少至5个。

A research team at the Johns Hopkins University School of Medicine trained baboons and squirrel monkeys to orally self-administer an Adderall-like drug for two to four weeks, and the team found evidence of amphetamine-induced brain damage, specifically, lower levels of dopamine and fewer dopamine transporters on nerve endings in amphetamine-treated primates than in untreated animals.

一个研究小组在约翰霍普金斯大学医学院的训练狒狒和松鼠猴口头自我管理的Adderall等类药物的2到4周,而且该研究小组发现的证据苯丙胺诱导的脑损伤,特别是较低层次的多巴胺多巴胺转运体和减少对神经末梢的安非他明的待遇比未经处理的灵长类动物。

The dose-dependent experiment revealed that Id1 antagonised E47 and Ets1 mediated transcriptional activation in a dose-dependent manner. With pGL3-870 as a template, site-directed mutagenesis of E-box and / or ETS-binding site was introduced into p16 promoter. E47 could not activate the transcription of p16 promoter with E-boxes mutated, and Ets1 could not activate the transcription of p16 promoter with EBS mutated. The synergy effect between E47 and Ets1 would occur only if the E-boxes and EBS were present. These facts demonstrated that E47 and Ets1 proteins were not recruited to the promoter by binding to other cis-elements or through interaction with other protein factors, however, they bound to DNA directly through respective consensus sequences in p16 promoter.

以pGL3-870为模板,构建了E-box或/和EBS点突变的p16启动子报告基因载体,将野生型和突变型的报告载体分别与pI-E47、pI-Etsl以及pI-E47+pI-Ets1共转染,发现E47和Ets1所诱导的转录激活作用依赖于启动子DNA上存在的各自的特异结合序列,二者的协同作用也只有当两个结合位点都存在时才会发生,说明E47和Ets1不是与其它作用元件或其它蛋白质因子相作用而被招募到该启动子的,它们是通过启动子上各自的特异结合位点与DNA直接结合的。

The stimulatory effect on the MMP-13 promoter was partially inhibited by mutation of the osteoblast-specific element 2 (OSE-2) binding site ⑸ Core binding factor-1 (Cbfa-1) expression peaked at 7 days ⑹ of differentiation, and was phosphorylated by PKG in itro.

免疫组织学检查揭示在17天大的embryo iNOS缺乏的老鼠MMP-13和Cfba-1表达水平均降低。Cfba-1 mRNA的沉默阻滞MMP-13的表达,不影响内源性的NO产生,肯定了他在MC3T3-E1细胞中NO诱导的MMP-13的表达中的作用。

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In the United States, chronic alcoholism and hepatitis C are the most common ones.

在美国,慢性酒精中毒,肝炎是最常见的。

If you have any questions, you can contact me anytime.

如果有任何问题,你可以随时联系我。

Very pretty, but the airport looks more fascinating The other party wisecracked.

很漂亮,不过停机坪更迷人。那人俏皮地答道。