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Aim: To investigate the effect of anemonin on release of endothelin-Ⅰ and nitric oxide induced by lipopolysaccharide in primary cultures of rat intestinal microvascular endothelial cells.

目的:探讨白头翁素对细菌脂多糖诱导的肠黏膜微血管内皮细胞内皮素和一氧化氮分泌增加的影响。

The results indicate that anemonin may have anti-inflammation action, at least in part, by inhibiting the secretion of both NO and ET-Ⅰ induced by LPS.

白头翁素可以下调LPS诱导的ET-Ⅰ和NO分泌增加,这可能是白头翁的抗炎机制之一。

AIM:To study the protective effects and mechanism of Ligustrazine against damage and apoptosis in human umbilical vascular endothelial cells induced by 160 μ mol/L arachidonic acid.

目的:研究川芎嗪对花生四烯酸(160 μ mol/L)诱导的血管内皮细胞损伤和凋亡的保护作用及其机制。

Alterations of hypothalamic AMPK activity augment changes in arcuate neuropeptide expression induced by fasting and feeding.

下丘脑AMPK活性的改变增加了弓状核由禁食和进食所诱导的神经肽表达变化。

STAT1 is critical for endoplasmic reticulum stress/type A scavenger receptor-induced apoptosis in primary tissue macrophages and in macrophage apoptosis in advanced atheromata.

在原代组织和进展的脂质斑块中,STAT1对于内质网应激/A型清道夫受体诱导的巨噬细胞凋亡其关键作用。

Three types of initial explants from Tilia miqucliana, including stem of seedlings, leaf and root of axenic plantlet, were used to study the organogenesis in this thesis.

本研究以南京椴无菌试管苗的茎段、叶片、根系为外植体,进行器官发生研究,探讨了不同因素对南京椴直接器官发生以及愈伤组织诱导的影响。主要结果如下: 1。

The effect of polyamines on callus browning and synthesis of endogenous polyamines and enthene during the development of callus,which initiated from mature embryo of Buchloe dactyloides texoka,was studied.

以野牛草成熟胚诱导的愈伤组织为材料,研究了外源多胺对愈伤组织褐化的影响及愈伤组织不同生长时期内源多胺和乙烯合成代谢规律。

Results:The experiments showed that 59 components were identified,accounting for 72.91 percent of the total essential oil.The essential oil was mainly composed of dehydrocostuslactone、costunolide、cedrenol、α-elemene、1,3-cyclooctadiene、eudesmol、α-selinene、β-caryophyllene、-longifolene、3,4-octadiene,7-methyl-etc.Among them Lactones like Dehydrocostuslactone and costunolide are essential components.

结果:GC-MS法分析鉴定了木香挥发油中59个成分,其主要成分为去氢木香内酯、木香烃内酯、雪松烯醇、α-榄香烯、环辛二烯、桉叶醇、α-芹子烯、丁子香烯、长松叶烯、7-甲基-3,4辛二烯等,占挥发油总量的72.91%;首次发现木香挥发油及去氢木香内酯、木香烃内酯具有抑制ADP诱导的血小板聚集活性。

However, tretinoin-induced gene expression was obviously inhibited by chelerythrine chloride.

而chelerythrine chloride能明显抑制维A酸诱导的神经组织细胞特异蛋白Nestin、NeuN和NF-M的表达。

The 20-HETE-induced increases in [Ca2+]i, whole-cell L-type Ca2+ channel currents and the amplitudes of Ca2+ transients were blocked by extracellular application of chelerythrine (an inhibitor of protein kinase C, PKC) and H-89 (an inhibitor of cAMP-dependent protein kinase, PKA).

上述20-HETE诱导的[Ca2+]i、全细胞L-型钙离子通道电流、钙瞬变幅度的增加等效应,可被蛋白激酶C抑制剂白屈菜红碱和cAMP依赖蛋白激酶抑制剂H-89阻滞。

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