诱导地

The works in the project just done can be summarized as five respects.(1) A device was designed to fabricate the asymmetrical resonant cavities by a pendant drop. A series ARCs with variable parameters provides a valuable experimental method for investigating the characteristics of ARCs.(2) The relationship between the number of active modes and the shape parameters in an ARC was investigated. The experimental lasing threshold was compared with theoretical result, the good agreement between two shown that it was the decrease of the number of active modes in an ARC that decreased lasing threshold.(3) Dye lasing gain was used to enhance the signals of stimulated Raman scattering of the weak gain Raman modes in a circular cavity made by a pendant drop, the instantaneous SRS spectra of weak gain Raman modes in ethanol was obtained by this new method.(4) The SRS signals of minority compound in a binary chemical complex was obtained by using dye lasing gain method. The detection concentration of minority compound was reduced to an order compared with normal SRS method.(5) A cylindrical circular cavity was formed by a liquid jet, which was used to reduce the pump intensity required for laser induced plasma spectroscopy. The limit of detection of trace element in aqueous sample was greatly decreased by this new method.

我们设计并成功制作了使悬垂液滴连续变形的装置，用此装置可以方便地改变非圆对称谐振腔的几何参数，为ARCs的研究提供了一种有效的实验方法；研究了ARCs中活性模式数和变形参数间的变化规律，激光阈值的数值计算结果和激光辐射的实验结果作了比较，二者吻合的曲线说明ARCs中活性模式数量的减少是受激辐射放大阈值降低的原因；在由单元化合物构成的微型圆对称谐振腔中，首次尝试用"激光增益"增强弱增益拉曼模式的受激拉曼散射信号，获得了乙醇分子中弱增益拉曼模式的瞬态SRS光谱；在由二元混合物构成的微型圆对称谐振腔中，用染料的激光增益增强了少量化合物的SRS信号，把少量化合物的SRS信号探测浓度降低了近一个数量级，在SRS应用于瞬态过程的组份分析方面做了卓有成效的探索；用石英毛细管形成的稳定液拄构成拄形谐振腔，降低了激光诱导等离子体光谱需要的激励能量，有效地降低了水相样品的痕量元素分析极限，为LIPS应用于微量元素的化学分析开拓了一条新的技术路线。

The extracellular edelfosine promoted the phosphatization of Spmlvia inducing the expression of Mid2; The intracellular edelfosine increased the phosphatization of Spmlvia inhibiting the expression of Pmp1, and leading the holdback of cytokinesis.

细胞外依地福新诱导Mid2蛋白的表达，从而促进的Spm1磷酸化；细胞内依地福新通过抑制Pmp1蛋白的表达，取消Pmp1蛋白对Spm1的抑制作用，使Spm1的磷酸化程度增加，最终导致粟酒裂殖酵母细胞胞质分裂障碍。

Salsa under salt stress indicated that the expression of tonoplast H〓-ATPase subunit H in leaves, shoots and roots were all significantly induced by NaCl stress.

本实验较为详细的研究了盐地碱蓬液泡膜H〓-ATPase H亚基在盐胁迫下的表达变化，发现其在盐地碱蓬植株根、茎、叶的表达均明显被盐胁迫所诱导。

The BMSCs were divided into six groups after repeatedly passaged: A,the BMSCs were cultured with conventional culture fluid(DMEM culture fluid+20%fetal bovine serum+2 mmol/L aminoglutaric acid amine) all the time;B,the BMSCs were cultured with conventional culture fluid+HGF(25ng/ml)+dexamethasone10~(-7M;C(HGF and Zuoguiwan induced group), the BMSCs were cultured with conventional culture fluid+ HGF(25ng/ml)+ dexamethasone10~(-7M+ 10%Zuoguiwan drug serum;D(conditioned medium and contrast serum induced group), the BMSCs were cultured with conventional culture fluid+50 % conditioned medium+10 % normal rat serum;E(conditioned medium and Bazhentang drug serum induced group), the BMSCs were cultured with conventional culture fluid+50 % conditioned medium+10 % Bazhentang drug serum;F(conditioned medium and Zuoguiwan drug serum induced group), the BMSCs were cultured with conventional culture fluid+50 % conditioned medium+10% Zuoguiwan drug serum.

常规培养组始终使用常规培养液(DMEM培养液+体积分数20％胎牛血清+2mmol／L谷氨酸胺)进行培养；HGF诱导组以常规培养液+促肝细胞生长因子(HGF，25ng／ml)和地塞米松10~(-7M进行培养；HGF加左归丸组以常规培养液+促肝细胞生长因子(HGF，25ng／ml)和地塞米松10~(-7／M+10％的左归丸含药血清进行培养；条件培养液加对照血清组以常规培养液+50％的条件培养液+10％正常大鼠血清进行培养；条件培养液加八珍汤组以常规培养液+50％的条件培养液+10％八珍汤含药血清进行培养；条件培养液加左归丸组以常规培养液+50％的条件培养液+10％左归丸含药血清进行培养。

To obtain more messages from Ardisia, some studies, such as characters of seeds germination and storage, factors influencing callus induction and growth, monitoring bergenin in callus of Ardisia spp and plant regeneration of Ardisia spp, were carried out. As a result, calli were obtained from nine species of Ardisia and bergenin, the major pharmaceutical element of Ardisia, was proved to exist in six of them when checked by HPLC. Plant regeneration systems were established from three species of Ardisia too. These works are all reported for the first time.

为更好地利用该属植物资源，本文对紫金牛属植物的种子萌发和贮藏，愈伤组织的诱导和培养，培养物中岩白菜素含量的检测，植株再生等问题进行了研究，首次成功地获得了紫金牛属9个种的愈伤组织并在其中6个种中检测到主要药用成分岩白菜素的存在，同时首次建立了该属3个种的再生体系。

And fish lice, Argulus sp. Induced spawning using only photothermal control has not occurred, but GnRHa implants hae been successfully used to induce oulation and allow strip-spawning. In addition, during 1997, photothermal conditioning coupled with 100 mg GnRHa implants resulted in successful tank-spawning. During a 99-day period, eggs were collected on 64 days and lowering temperature was shown to inhibit spawning.

和 Argulus sp。，产卵的诱导采用光照控制和GnRHa注射的方法，并成功地试亲鱼排卵和进行流水孵化。1997年中，光照控制和100mg GnRHa注射所得栾成功地进行了静水孵化。

Majority of acute leukemias in infant, either acute lymphoblastic leukemia or acute myeloblastic leukemia, posses a chromosomal translocation affecting the 11q23 chromosome region which specifically inoles the mixed-lineage leukemia gene.1-3 Most pediatric leukemias with MLL rearrangement clearly hae a remarkably short latency.1,4 MLL gene rearrangement is also associated with secondary leukemias of patients preiously treated with the topoisomerase II inhibitors.4 The latency of these secondary leukemias is similarly ery short.4 Of note, the concordance rate of leukemia with MLL rearrangement in infant monozygotic twins approximates to 100%,1,4 and identical breakpoint in the MLL gene was shared in these pairs of identical twin infants with concordant ALL.1,4 Moreoer, the unique and clonotypic MLL fusion gene was detectable in neonatal blood spots for Guthrie cards from non-twined indiiduals who subsequently deeloped ALL.1,4 These obserations indicate not only that MLL fusion is generated in utero but also that MLL fusion proteins could be capable of inducing leukemic transformation with few, if any, secondary mutations.2,3,4 Greaes et al speculate that an MLL fusion protein somehow promotes rapid transition to full-blown disease in patients ia ery rapid clonal expansion, genetic instability, or inhibition of DNA damage repair.4 In general, for clonal expansion of malignancies, tumor cells often hae acquired strategies that escape immune sureillance of the hosts.5,6 Immune escape mechanisms also contribute to the failure of graft-ersus-leukemia effect after allogeneic hematopoietic stem cell transplantation.7 Therefore, leukemia cells could acquire some immune escape mechanisms during leukemogenesis.

绪论 绝大多数的婴儿白血病，不管是急性淋巴性白血病或是急性骨髓性白血病，在染色体11q23部位有染色体易位的情况；这个部位的染色体易位牵连了混合谱系白血病基因。大多数具有MLL基因重排的儿童白血病潜伏期明显短很多。MLL基因重排也和经拓扑异构酶II抑制剂治疗后的继发性白血病有关。这些继发性白血病的潜伏期类似地都非常的短。很重要的是，单卵双胞胎婴儿同时患有或同时免于MLL基因重排阳性的白血病的一致性接近100%；并且同样患有ALL的同卵双胞胎的MLL基因的断裂点是一致的。而且，这种独特的克隆特异性的MLL融合基因能够从那些得ALL的非双生个体出生时的血斑标本中检测到。这些发现表明MLL融合基因产生在胎儿还在子宫的是后，而且MLL融合蛋白能过和其他的基因突变一起诱导白血病的产生。Greaes 等推测MLL融合蛋白在某种情况下同过快速克隆增殖，遗传的不稳定性或是DNA损伤修复的抑制促使疾病迅速地全面爆发。恶性肿瘤细胞的克隆增殖通常已经获得了逃避机体免疫监视的能力。免疫逃避机制也归因于异体外周血干细胞移植后移植物抗白血病作用的失效。所以，白血病细胞在白血病的产生过程中可能获得了某些免疫逃脱机制。

To analyze effect of diclazuril and maduramycin on 18S rDNA of Eimeria tenella, the 18S rDNA of sporulated oocyst of the E. tenella anti-diclazuril strain, the E. tenellaanti-maduramycin strain and the E. tenella drug-sensitive strain were cloned and sequenced, and were compared by using DNAStar 5.0 and RNADraw 1.1, respectively.

为探讨抗球虫药物地克珠利和马杜拉霉素对柔嫩艾美球虫18S rDNA的影响，分别对人工诱导的柔嫩艾美球虫地克珠利抗药株、马杜拉霉素抗药株和药物敏感株孢子化卵囊的18S rDNA基因进行了克隆测序，并通过生物信息软件进行对比差异分析。

Gelatin microsphere is firstly made by encapsulating bFGF into gelatin by special manufacture process, then this microsphere was combinated into PLGA conduit or PLGA film.when used, we need only pack the injury peripheral nerve, injury spinal cord, wounded pars encephalic with the PLGA conduit. The conduit or film can slowly release buff which would be absorbed by around tissues.bFGF was already proved to be nutritious to the regeneration and alive of neuron and protect injury neuron.bFGF can also promote morphogenesia and division of nerve cell which would raise the survival rate of neuron, guide the generation of axon etc.bFGF is one of the important factors of sustaining the normal survival of cholinergic nerve.

使用时，只需将此材料贴敷外周损伤神经伤患处，脊髓伤口，或在脑部开颅手术后填充于术后创面，可有效地在伤口局部缓慢地释放并由机体组织吸收bFGF等神经营养因子。bFGF等已被证明具有神经营养作用，可促进神经元的再生与存活，保护受损的神经元。bFGF等对神经细胞兼有促进形态发生与分裂作用，具有提高神经元的成活率、诱导轴突向外生长等功能，是维持前脑基底部胆碱能神经元正常生存的重要因素。

Before treatment,there are abundant microvtlli on the cell surface,many filoplodia on the cell rim,few of endoplasmic reticulums , Golgi complexes and mitochondrions with abnormal structure and lots of free ribosomes in the cytoplasm. The shape of nucleus is irregular with high nuclear-cytoplasmic ratio, many dark pellets of heteromatin and a few of nucleoluses in which there ar...

经1.5×10~2g/L地塞米松处理后，细胞表面微绒毛和丝状伪足显著减少或消失，出现皱褶状和小泡状结构；细胞核形规则，核质比值减小，异染色质团块减少，核仁数目减少、结构致密；细胞质中粗糙型内质网、高尔基体、线粒体数量增多，形态结构典型，游离核糖体减少，这些变化说明地塞米松改变了MGc80-3细胞的超微结构特征，具有明显的诱导分化作用。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。