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Optically active axially dissymmetric binaphthyl derivatives have been extensively used as excellent chiral ligands in asymmetric catalysis and chiral recognition.

光学活性的联萘衍生物以其独特的立体化学性质作为优异的C2轴手性诱导源,已被广泛地应用到不对称催化反应和手性识别中。

The process of our study links some of the most basic questions about C〓 with beautiful classical results from analyticfunction theory. For instance, it is essential Littlewood subordination theorem that assures that composition operators act boundedly on many analytic function spaces. And there are close connections between the compactness of C〓 and the existence of angular derivatives of ψ at points of 〓D. It involves the classical Julia-Careatheodory theorem, Denjoy-Wolff theorem and Nevanlinna counting functions and so on. It makes many old theorems in analytic-function theory getting some new meanings, and bestows upon functional analysis an interesting class of linear operators. This thesis consists of six chapters as follows: Chapter 1 is a preparatory in nature.

从而建立了C〓的算子性质与解析函数论中许多漂亮的经典结果之间的联系,如许多解析函数空间上复合算子的有界性本质上往往是著名的Littlewood从属原理,复合算子的紧性与其诱导映射在边界〓D上的角导数之间有着紧密的联系等等,这样自然而然地涉及到经典函数论中的Julia-Caratheodory定理,Denjoy-Wolff定理及Nevanlinna计数函数等等一些结果,并以此赋予函数论中许多古老问题以新意,同时也为泛函分析提供了一类十分具体的线性算子。

The structural and photocatalytic properties of TiO〓 as well as surface acidity were greatly improved by sulfation. SO〓〓/TiO〓 solid superacid with Hammett constant Ho less than -12.14 was prepared by treating the TiO〓 with 1.0mol. L〓 sulfuric acid solution and then calcining at 450℃ for 3h. When compared to unmodified TiO〓, the SO〓〓/TiO〓 superacid catalyst exhibited higher anatase content, smaller crystal size, higher specific surface area, centralized pore size distribution, and the blue-shifted band edge of uv-vis adsorption spectra. Furthermore, the SO〓〓/TiO〓 superacid also showed excellent reaction activity and stability for CH〓Br photocatalytic decomposition even under the moist reaction conditions. The apparent quantum efficiency of SO〓〓/TiO〓 was 10 times of that of TiO〓 catalyst for the photocatalytic degradation of bromomethane. Therefore, the SO〓〓/TiO〓 superacid catalyst is promising for practical application in environmental remediation.It was found that both L and B acid sites exist on SO〓〓/TiO〓 photocatalyst while only L acid sites on TiO〓 photocatalyst. On the basis of experimental results, the synergistic model of superacidic centers was proposed for SO〓〓/TiO〓 photocatalyst to explain the photocatalytic behavior and the mechanism of superacidifing effects, assuming that the adjacent L and B acid sites induced by SO〓〓 comprise cooperatively the superacidic center on superacid photocatalyst. The group cooperation of the superacidic center could strengthen the surface acidity, increase surface acid sites and the adsorbtion of O〓, promote separation of photogenerated electron-hole pair, enhance the interfacial transfer of charges and reversibility of water adsorption. Consequently the excellent photocatalytic activity, reaction stability and resistibility to humidity of SO〓〓/TiO〓 superacid photocatalyst may attributed to the group cooperated effect of the superacidic center on the photocatalyst.

研究结果表明:SO〓〓与TiO〓表面的结合为螯合式双配位结构;TiO〓光催化剂表面经H〓SO〓浸渍处理后,提高了表面酸性,改善了催化剂结构和光催化性能,当H〓SO〓浸渍浓度为1.0mol.L〓、烧结温度为450℃时,可制得SO〓〓/TiO〓超强酸催化剂(H〓<-12.14),其结构和光催化活性得到明显改善,与TiO〓相比,SO〓〓/TiO〓光催化剂的锐钛矿含量高、晶粒小、BET比表面积大、孔径分布集中、光谱吸收边蓝移,具有优异的光催化氧化活性、稳定性及抗湿性能,光催化降解溴代甲烷的表观量子效率比TiO〓催化剂提高了一个数量级,是一种有实际应用前景的高效光催化剂;由此提出了SO〓〓/TiO〓超强酸催化剂表面集团协同作用的超强酸中心模型,认为在SO〓〓/TiO〓超强酸催化剂表面,由SO〓〓诱导的相邻L酸中心和B酸中心组成了集团协同作用的超强酸中心,其集团协同作用显著地增强了催化剂表面酸性、增大了表面酸量及O〓吸附量、促进了光生电子和空穴的分离及界面电荷转移,具有可逆吸附水的性能,是SO〓〓/TiO〓超强酸催化剂具有优异的光催化氧化活性、很好的活性稳定性及抗湿性能的重要原因。

The apparent quantum efficiency of SO〓〓/TiO〓 was 10 times of that of TiO〓 catalyst for the photocatalytic degradation of bromomethane. Therefore, the SO〓〓/TiO〓 superacid catalyst is promising for practical application in environmental remediation.It was found that both L and B acid sites exist on SO〓〓/TiO〓 photocatalyst while only L acid sites on TiO〓 photocatalyst. On the basis of experimental results, the synergistic model of superacidic centers was proposed for SO〓〓/TiO〓 photocatalyst to explain the photocatalytic behavior and the mechanism of superacidifing effects, assuming that the adjacent L and B acid sites induced by SO〓〓 comprise cooperatively the superacidic center on superacid photocatalyst. The group cooperation of the superacidic center could strengthen the surface acidity, increase surface acid sites and the adsorbtion of O〓, promote separation of photogenerated electron-hole pair, enhance the interfacial transfer of charges and reversibility of water adsorption. Consequently the excellent photocatalytic activity, reaction stability and resistibility to humidity of SO〓〓/TiO〓 superacid photocatalyst may attributed to the group cooperated effect of the superacidic center on the photocatalyst.

研究结果表明:SO〓〓与TiO〓表面的结合为螯合式双配位结构;TiO〓光催化剂表面经H〓SO〓浸渍处理后,提高了表面酸性,改善了催化剂结构和光催化性能,当H〓SO〓浸渍浓度为1.0mol.L〓、烧结温度为450℃时,可制得SO〓〓/TiO〓超强酸催化剂(H〓<-12.14),其结构和光催化活性得到明显改善,与TiO〓相比,SO〓〓/TiO〓光催化剂的锐钛矿含量高、晶粒小、BET比表面积大、孔径分布集中、光谱吸收边蓝移,具有优异的光催化氧化活性、稳定性及抗湿性能,光催化降解溴代甲烷的表观量子效率比TiO〓催化剂提高了一个数量级,是一种有实际应用前景的高效光催化剂;由此提出了SO〓〓/TiO〓超强酸催化剂表面集团协同作用的超强酸中心模型,认为在SO〓〓/TiO〓超强酸催化剂表面,由SO〓〓诱导的相邻L酸中心和B酸中心组成了集团协同作用的超强酸中心,其集团协同作用显著地增强了催化剂表面酸性、增大了表面酸量及O〓吸附量、促进了光生电子和空穴的分离及界面电荷转移,具有可逆吸附水的性能,是SO〓〓/TiO〓超强酸催化剂具有优异的光催化氧化活性、很好的活性稳定性及抗湿性能的重要原因。

Spontaneous differentiation of ESCs and iPSCs into cardiomyocytes is however limited. To elucidate the regulatory mechanisms and effectively differentiate these pluripotent cells into specific cardiomyocytes are crucial to obtain fundamental knowledge in cardiogenesis, screen drugs and promote the usage of these cells in replacement therapy. This review summarizes the current state of differentiation of cardiomyocytes from mouse and human ESCs and their regulatory factors.

但这些多能干细胞向心肌细胞自发分化的效率非常低,因此,如何有效地诱导这些多能干细胞向心肌细胞的定向分化对深入认识心肌发生发育的关键调控机制和实现其在药物发现和再生医学,如心肌梗塞、心力衰竭的细胞治疗以及心肌组织工程中的应用均具有非常重要的意义。

Spontaneous differentiation of ESCs and iPSCs into cardiomyocytes is however limited. To elucidate the regulatory mechanisms and effectively differentiate these pluripotent cells into specific cardiomyocytes are crucial to obtain fundamental knowledge in cardiogenesis, screen drugs and promote the usage of these cells in replacement therapy.

但这些多能干细胞向心肌细胞自发分化的效率非常低,因此,如何有效地诱导这些多能干细胞向心肌细胞的定向分化对深入认识心肌发生发育的关键调控机制和实现其在药物发现和再生医学,如心肌梗塞、心力衰竭的细胞治疗以及心肌组织工程中的应用均具有非常重要的意义。

Doetschman TC, Eistetter H, Kemler R, et al. The in vitro development of blastocyst-derived embryonic stem cell lines: formation of visceral yolk sac, blood islands and myocardium [J]. J Embryol Exp Morph, 1985,87:27~45.[2] Robbins J, Doetschman T, Jones WK, et al. Embryonic stem cell as a model for cardiogenesis[J]. Trends Cardiovasc Med, 1992,2:44~50.[3] Moreadith RW, Radford NB.

被诱导的心肌细胞的判定除常规指标外,我们还用了心脏特异性引物β-MHC对不同收缩时间的心肌细胞总RNA进行RT-PCR扩增和RNA斑点杂交,发现该心肌细胞不仅具有正常心肌细胞的特性,而且在分化早期就高度地表达心脏特异性基因。

After 3 weeks, some cells turned to round shape and secreted metachromatic matrix. The cartilaginoid grafts composed of chondrogenic MSC.

向MSC培养液内加入地塞米松、转化生长因子-β1(TGF-β1)和维生素C进行软骨起源诱导培养3周,部分细胞开始转变为圆形并分泌基质。

Objective:To observe the inhibitory effect of EGCG on cataractous lenses of rabbits Dexamethason peroxide induced.To explore the validity of EGCG on the treatment of Dexamethason induced cataract formation.

目的:观察表没食子儿茶素没食子酸酯对抑制地塞米松诱导体外培养兔晶状体上皮细胞凋亡的作用,从而探讨EGCG对晶状体糖皮质激素损伤进行药物治疗的可行性。

In contrast, treatment with baicalein (1OOμM), wogonin (1OOμM) and chrysin (1OμM) increased the formation of TNF-α in macrophages stimulated by LPS (0.1μg/ml).

但相对地,在以脂多醣(0.1μg/ml)诱导巨噬细胞中,以baicalein(100μM)、wogonin(100μM)和chrysin(10μM)处理后,却会增加TNF-α的生成。

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