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Chiral nonracemic fluoro-organic molecules with a fluorine atom on a stereogenic center are readily prepared via chiral electrophilic fluorinating reagent-mediated enantioselective fluorinations, substrate-controlled enantioselective electrophilic fluorinations, chiral metal complexes and asymmetric catalyst—directed catalytic enantioselective fluorinations.

高光学活性的手性氟化物可通过手性亲电氟化试剂诱导的立体选择性氟化反应,基于底物的手性氟化反应以及手性催化剂诱导的不对称催化氟化反应等来制备。

With many years of research, two inbreeds 18-599 and 18-599 are sieved to be excellent on both characters of induction efficiency and number of regenerating. They also act much better comparing with those superior acceptors as B73, A188 and zong 31, which are known in foreign and home country, and their induction efficiency don't act different essentially, however their number of regenerating is much lower.

6经过多年的重复研究后筛选到的玉米幼胚培养胚性愈伤组织诱导率和胚性愈伤组织绿苗发生数等2个幼胚培养能力性状均表现十分优良的自交系18-599和18-599,与国内外公认的玉米转基因优良受体,如B73、A188和综31、中自03等相比较,它们不仅在幼胚培养胚性愈伤组织诱导率表现上没有实质性的差别,而且在胚性愈伤组织绿苗发生数的表现上要比后者优良得多。

The results showed as:(1)Gegen decreases fasting insulin and insulin resistance index and increases insulin sensitive index of rats of insulin resistance induced by dexamethasone significantly;(2)Gegen can improve glucose tolerance of rats of insulin resistance but not to alloxan indued diabetes mice;(3)Gegen increases glucose intake of 3T3-L1 adipocytes and improves the insulin resistance of 3T3-L1 adipocytes induced by dexamethasone significantly;(4)Gegen can activate peroxisome proliferator- activated receptor gamma, make it bind to PPAR response elements;(5)Gegen can up-regulate mRNA expression of PPAR v ,aP2 and adiponectin.

结果表明:①葛根显著降低地塞米松诱导的胰岛素抵抗大鼠血清胰岛素水平和胰岛素抵抗指数,升高胰岛素敏感指数,改善大鼠的胰岛素抵抗;②葛根显著改善胰岛素抵抗大鼠的糖耐量,但对四氧嘧啶糖尿病小鼠的糖耐量没有明显的作用;③葛根显著增加胰岛素抵抗3T3-L1脂肪细胞对葡萄糖的摄取,改善地塞米松诱导的3T3-L1脂肪细胞的胰岛素抵抗;④葛根能促进HepG2肝癌细胞过氧化物酶体增殖物激活受体γ与靶基因的特异DNA序列结合,对PPARγ及其下游基因的转录具有激活作用;⑤葛根能够促进PPARγ及其下游基因脂肪酸结合蛋白(aP2)、脂联素mRNA的表达。

Then detected the blook pressure, heart rate changes before inducing of anesthesia and 2min after inducing, 1min after trachea intubating.

监测麻醉诱导前,诱导后2min,气管插管后1 min血压、心率的变化。

The Food and Drug Administration of USA hasapproved the use of this topical medicine for treatment of different malignant andpremalignant tumors such as actinic keratoses and basal cell carcinoma. Althoughimiquimods exact mechanisms of action in neoplastic diseases has not yet been fullyelucidated, animal and human studies have shown its ability to enhance the productionof cytokines such as interferon-, interleukin-12, and tumor necrosis factor- though conjugations with Toll like receptors on the surface of dendriticcells of the monocyte-macrophage lineage.

有关咪喹莫特抗癌作用的具体机制仍不十分明了,一般认为,咪喹莫特主要是通过与免疫相关细胞表面的Toll样受体结合、促进IFN-α、TNF-α、IL-12等多种前炎症细胞因子的分泌,进而激活天然与获得性免疫反应的方式发挥抗癌作用;进一步的研究发现,咪喹莫特尚能选择性的抑制某些皮肤肿瘤细胞的增殖并诱导其凋亡,提示增殖抑制和诱导凋亡可能是评价咪喹莫特抗肿瘤作用的重要指标和机制。

Gastric washing, sputum induction using nebulized hypertonic saline, and bronchoscopy with bronchoalveolar lavage have all been used to obtain specimens for diagnosis, but to our knowledge, the timing and volume of induced sputum have not been well studied, and these 3 methods have not been compared.

洗胃,使用高张生理盐水雾化诱导咳痰,以及用支气管肺泡灌洗进行的支气管镜检查均被运用于诊断获得的样本,但据我们所认识到,诱导咳痰的时机和容量还未被研究,并且这3种方法尚未比较。

Acicular ferrite microstructure in micro-alloyed steels, which nucleates around non-metallic inclusions, especially oxide inclusions, has high strength and good toughness and possesses strong grain-refining ability by itself. The ultra-fine grained steel with excellent weldability is likely to be produced by forming in materials a great number of fine and dispersive micro-inclusions which is helpful to induce AF to nucleate around them through oxide metallurgy technology.

微合金钢针状铁素体组织强度高、韧性好,在奥氏体晶内非金属夹杂物上诱导形核,具有很强的自身细化晶粒的能力,通过氧化物冶金技术控制钢铁材料形成大量细小、弥散,具有诱导AF形核能力的有益微夹杂物,有望获得焊接性能优良的超细晶粒钢。

Overproduced YlyA existed as inclusion body, while the induction was carried out with 0.5mM IPTG, at 37℃ for 3h; Modified the induction condition to 0.05mM IPTG, at 25℃ for 5h, a portion of His-tagged YlyA turned into soluble; After purification treatment, the concentration of the fused protein reached to 204.2119μM.

结果表明pNG252中ylyA的插入方向正确,序列无突变;用0.5mM IPTG ,37℃诱导3h时,YlyA虽高效表达,但为包涵体形式;调整诱导条件至0.05mMIPTG,25℃,5h时,高效表达的YlyA部分转为可溶性蛋白。

1 MSC derived from rabbit bone marrow can establish expanding-culture in vitro, and no change was observed in either morphology or characteristic after passaging and recovery.

兔骨髓MSC经BME诱导可表达nestin和NSE;诱导后的MSC在神经培养基继续培养,存活且分子标志的表达无增减。3。

Two series of polyurethane acrylate grafted acrylic resins (Acr-g-TPU-PETA and Acr-gPPU-PETA) self-emulsifying systems are obtained by grafting -NCO group modified polyurethane acrylates with acrylic copolymer prepared from n-butyl acrylate, styrene,βhydroxyethyl methacrylate and acrylic acid The self-emulsifying systems showed Newtonian fluidity with viscosity closed to that of water, the solid contents were around 30% The T〓 of 15~4℃ for dried film before photocuring favored film formation at room temperature DSC and DMA results showed that PU-PETA is compatible with acrylic resin in the grafted resin The TG and dTG curves for Acr-g-PU-PETA samples were substantially different from the corresponding blends, and the brodened dTG peaks for photocured grafted resin suggest that there might be multiple interactions among chain segments The photocued film of the grafted resins self-emulsifying system exhibited good overall properties with polyurethane acrylate grafts ranging from 30% to 50%, and Acr-g-TPU-PETA series showed better properties than Acr-gPPU-PETA series The adhesion of the photocured film was 1~2 grade, impact strength was 50kg-cm and flexibility was 1mm The Shore hardness and the adhesion of the film decreased markedly if PETA was replaced by HEMA as photoactive group due to the lower C=C double bond content in the grafted resin The polyhydroxy amine-linked thioxanthones photoinitiators can be evenly dispersed in self-emulsifying system without color spot appearing in the dried film The films photocured with IV〓~IV〓 generally exhibited higher Shore hardness, gloss and solventresistance than that cured with Irgacure 2959 and did not induce the rusting of the iron substrate Pigmenting with titanium oxide had no effect on the photocuring The polyhydroxy amine-linked thioxanthone IV〓 and IV〓 can be new candidates for the formulation of titanium oxide pigmented photocurable water-borne coatings for their pale-yellow appearance and slight interference with the color of the coatings WB 4759 with high water-solubility coalesced and separated from the dried resin film, and even induced the rusting of iron substrate.

以丙烯酸丁酯,甲基丙烯酸-β-羟乙酯,丙烯酸及苯乙烯合成厂丙烯酸共聚树脂,并与含-NCO端基的聚氨酯丙烯酸酯接枝反应,经水性化后,得到两个系列(Acr-g-TPU-PETA和Acr-g-PPU-PETA)各5个不同配比的丙烯酸树脂接枝聚氨酯丙烯酸酯自乳化体系,粘度与水相近,为牛顿流体,固含量30%左右。光固化前干燥涂膜的玻璃化转变温度在-15℃~4℃之间,有利于室温下成膜。DSC及DMA谱表明两种树脂基本相容。Acr-g-PU-PETA的热失重行为明显不同于共混材料,接枝样dTG峰明显宽化,表明接枝样中链段之间的相互作刚有多重性,丙烯酸树脂与聚氨酯之间有一定的相容性。接枝树脂自乳化体系光固化涂层的综合性能以聚氨酯丙烯酸酯成分为50%~30%者相对较好,且以Acr-g-TPU-PETA系列更理想。光固化膜的附着力为1~2级,冲击强度为50kg·cm,柔软性多为1mm。以HEMA代替PETA作为接枝树脂的活性基团,碳—碳双键密度太低,光固化膜交联点太少,硬度和附着力均较差。多羟基胺连硫杂蒽酮光引发剂能均匀分散于树脂自乳化体系和接枝树脂干膜中,不出现色斑,光固化膜肖氏硬度一般高于以Irgacure 2959为光引发剂的光固化膜,光泽度及耐丁酮溶剂性能均有所提高,不会诱导铁基生锈,钛白着色对光固化结果几乎没有影响。本论文所合成的多羟基胺连硫杂蒽酮光引发剂IV〓与IV〓为浅黄色,对光固化涂层的颜色干扰较小,为配制钛白着色光固化水性涂料提供了新的光引发剂。水溶性太强的WB 4759在干膜中易聚结析出,且对所附着的铁基有诱导锈蚀作用。

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