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All enhancers did not significantly change the transcorneal lag time of ENX. The irritancy of poloxamer and Azone was observed.? The results of in vitro release studies showed that the ENX gel based 3% HPMC K4M and 3%HPMC F4M povided sustained release of the drug over an 8-h period in vitro.Diffusion area has significantly effect on drug release, and pH value of medium and rotation rate have effcet on drug release.However, the diffusion shield has no effect on drug release. The P_ value of the preparation based on 3% HPMC F4M was 1.34-fold of conventional eye drops of ENX.

体外溶出度试验结果表明,以3%的HPMC K4M和F4M为基质制备的ENX凝胶剂的体外释放行为符合眼用缓释制剂的要求;体外释放度影响因素试验结果表明,释放面积对释放度有显著性影响,pH值和转速略有影响,而扩散屏障没有影响;离体角膜透过实验结果表明,以F4M为基质制备的凝胶剂中ENX的表观渗透系数P_(app是对照组的1.34倍,说明F4M与眼角膜的相容性较好,是一种理想的眼用制剂增稠剂,可以在眼用制剂中广泛采用。

Dr Read's research would also open our eyes to new areas of research on accurately measuring pressure from the eyelids, and how these corneal changes may affect the deelopment of short sightedness.

Read博士的研究让我们开阔眼界,让我们注意到来自眼睑的精确的压力的研究,以及由此带来的角膜改变对近视的发展的可能影响。

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But we don't care about Battlegrounds.

但我们并不在乎沙场中的显露。

Ah! don't mention it, the butcher's shop is a horror.

啊!不用提了。提到肉,真是糟透了。

Tristan, I have nowhere to send this letter and no reason to believe you wish to receive it.

Tristan ,我不知道把这信寄到哪里,也不知道你是否想收到它。