角化过度

Objective:To explore the clinicopathological,immunohistochemical feature and therapeutic methods of hyperkeratosis lenticularis perstans.

目的：提高对持久性豆状角化过度症的认识，探讨其临床、病理、免疫组化特征及治疗方法。

Methods:Analyze the clinicopathological,immunohistochemical feature and therapeutic methods of a case of hyperkeratosis lenticularis perstans.

分析1例持久性豆状角化过度症患者的临床、病理、免疫组化特征及治疗方法。

Vertical rotation law: can effectively remove plaque and debris, and can stimulate the gums, hyperkeratosis, to maintain the normal shape gums.

垂直旋转法：能有效清除牙菌斑和碎片，并能刺激牙龈，角化过度，维持正常的形状牙龈。

Hyperkeratosis lenticularis perstans is a rare keratoid dermatosis and CD4 - positive T cell - mediated immune reaction may play an important role in the pathogenesis of this disease.

持久性豆状角化过度症是一种临床少见的角化性皮肤病，CD4＋T细胞介导的免疫反应在HLP的发病中可能起着重要的作用，异维A酸口服及外用治疗该病有效。

Main HPV7(9/18) positive samples\' pathology manifestations matched the characteristics for HPV7 infection,which showed papillomatosis and acanthosis,deep-stained cells including keratohyalin granules in middle size,and obvious hyperkeratosis and parakertosis.

HPV7阳性(18份)的病理象特征：(1)乳头瘤样增生和棘层肥厚；(2)内含中等大小的透明角质颗粒的细胞深染；(3)显著的角化过度和角化不全。

We present a patient with multiple seborrheic keratosis-like lesions on the trunk with characteristic pathologic findings, which is first reported in Taiwan. The histology showed hyperkeratosis, acanthosis, and papillomatosis accompanied with acantholysis in the superficial epidermis.

我们报告一个病人在躯干有多个类似脂漏性角化症病灶，病理显示角化过度、棘层肥厚、有乳突瘤状增生以及上层表皮有棘层松解，与国外文献报告雷同，然而首次报告於台湾落叶性天庖疮病人。

Fig2 Histological changes of the grafts from control group4wk after transplantation,showed retaining parakeratosis,hyperk-eratosis and acanthosis etc ×200

图2 移植后4wk对照组移植皮片组织学改变，示保留角化过度、角化不全、棘层肥厚等略

Fig3 Histological changes of the grafts from AK auto Ab group4wk after transplantation,showed acanthosis was reduced,parakeratosis and hyperkeratosis was disappeared ×200

图3 移植后4wk AK auto Ab注射组移植皮片组织学改变，示棘层肥厚变轻，角化过度、角化不全消失略

Results among the 128 patients, 71.9% elder than 51-years-old, the lesions of 53.9% of patients located in the exposure sites, such as face and neck. For pathologic feature, six patterns were learned, the most frequent types were hyperkeratosis arid acanthosis. The clinical diagnosis consisted with pathologic diagnosis in 89 cases.

结果 六种类型脂溢性角化病的组织象均可见到，并以棘层肥厚型和角化过度型为主。51岁以上发病者占71.9%，头、面、颈等暴光部位发病者占53.9%，临床和病理诊断特合89例，临床误诊率30.47%。

At each age stage , Skin appears over - cornified cuticle , disappeared hair shaft and abnormal hair bulb and hair follide that filled with some cornified substances , but the dermis varied.

各年龄段无毛小鼠表皮均有一层角化过度的角质层，毛干消失，毛球结构不正常，毛囊被一些角化物质充填。

And Pharaoh spoke to Joseph, saying, Your father and your brothers have come to you.

47：5 法老对约瑟说，你父亲和你弟兄们到你这里来了。

Additionally, the approximate flattening of surface strip using lines linking midpoints on perpendicular lines between geodesic curves and the unconditional extreme value method are discussed.

提出了用测地线方程、曲面上两点间短程线来计算膜结构曲面测地线的方法，同时，采用测地线间垂线的中点连线和用无约束极值法进行空间条状曲面近似展开的分析。