角化病

This article reviews immunoregulatory mechanism and the application of imiquimod to cauliflower excrescence,actinic keratosis,Bowen diseases and cutaneous tumor.

本文对咪喹莫特的免疫调节机制及其在尖锐湿疣、光化性角化病、Bowen病和皮肤肿瘤中的应用予以综述。

Objective To study the expression of p63 protein in seborrheic keratosis and to investigate the correlation between p63 and SK.

目的 研究p63蛋白在脂溢性角化病中的表达，探讨其与脂溢性角化病发病的关系。

Objective To study the expression_r_r of p63 protein in seborrheic keratosis and to investigate the correlation between p63 and SK.

目的 研究p63蛋白在脂溢性角化病中的表达，探讨其与脂溢性角化病发病的关系。

Thus we suspected that patients of follicular keratosis might infect HPVs on the genetic background.

因此我们推测毛囊角化病或其乳头瘤样病损可能是在一定的遗传背景下合并了HPV的感染。

Methods Immunohistochemistry was utilized to measure the expression of AQP3 in tissue samples from 30 patients with seborrheic keratosis, 15 patients with Bowen′s disease, 32 patients with squamous cell carcinoma, 17 patients with malignant melanoma and 15 normal human controls.

应用免疫组织化学方法检测30例脂溢性角化病、15例Bowen病、32例鳞状细胞癌、17例恶性黑素瘤及15例正常人皮肤组织中AQP3的表达。

Methods By immunohistochemical staining, the expression of p73, p53 and Ki67 was examined in 19 cases of seborrheic keratosis, 16 basal cell carcinoma, 11 Bowen's disease, 5 squamous cell carcinoma,as well as in 10 normal skin controls.

方法应用免疫组化方法检测19例脂溢性角化病、16例基底细胞癌、11例Bowen病、5例鳞状细胞癌及10例正常人皮肤p73、p53、Ki67的表达。

According to domestic and foreign reports, psoriasis patients with concurrent Bowen disease, arsenic keratosis, are in the use of arsenic-containing drugs due to its incidence on the total amount of arsenic and applications.

据国内、外报告，银屑病病人并发的Bowen病、砷角化病，均系使用含砷的药物所致，其发病率与应用砷的总量有关。

Results among the 128 patients, 71.9% elder than 51-years-old, the lesions of 53.9% of patients located in the exposure sites, such as face and neck. For pathologic feature, six patterns were learned, the most frequent types were hyperkeratosis arid acanthosis. The clinical diagnosis consisted with pathologic diagnosis in 89 cases.

结果 六种类型脂溢性角化病的组织象均可见到，并以棘层肥厚型和角化过度型为主。51岁以上发病者占71.9%，头、面、颈等暴光部位发病者占53.9%，临床和病理诊断特合89例，临床误诊率30.47%。

Objective The GJB2, GJB6 and GJB3 genes are related to hereditary deafness and keratoderma. To investigate the genetic causes, we recruited a Chinese family and screened the proband with syndromic deafness and palmoplantar keratoderma for mutations in these three genes and analyzed the phenotype and hereditary traits.

目的 GJB2、GJB6、 GJB3基因与遗传性耳聋及角化病有关，以GJB2、 GJB6、 GJB3基因为候选基因，研究1例伴有掌跖角化病的综合征型耳聋先证者的分子病因，探讨其表型及遗传特征。

"Long-term skin cancer and actinic keratoses surveillance continue to be important,and repeated resurfacing procedures or courses of topical agents,such as fluorouracil or imiquimod, may be necessary," the researchers write."A largerstudy comparing trichloroacetic acid resurfacing for actinic keratoses reductionand nonmelanoma skin cancer prophylaxis would help validate the superiority ofthis resurfacing technique over the carbon dioxide laser andassess its cost-effectiveness compared with photodynamic therapyor imiquimod treatment." They cite improved patient compliance in the trichloroacetic-acid group, ease of performance in the outpatient setting, andsubjective measures of better tolerance as reasons this procedure is an attractive alternative to repeated courses with topicalagents or laser resurfacing.

研究者指出，长期皮肤癌和光化性角化病之监测仍是重要的，反覆的皮肤重建整形步骤、或外用制剂如fluorouracil 或 imiquimod的反覆疗程也可能是必须的；一个比较三氯醋酸皮肤重建整形以减少光化性角化病和预防非黑色素皮肤癌的大型研究，将可有助於确定其优於二氧化碳雷射的优势，以及评估其和光动力治疗或 imiquimod治疗之花费效益比比较；他们举例说，三氯醋酸组病患之遵医嘱性增加、门诊病患也容易进行、个案之测量耐受度比较佳，这些都是重复疗程时比外用药剂或雷射更有吸引力的理由。

On the other hand, the more important thing is because the urban housing is a kind of heterogeneity products.

另一方面，更重要的是由于城市住房是一种异质性产品。

Climate histogram is the fall that collects place measure calm value, cent serves as cross axle for a few equal interval, the area that the frequency that the value appears according to place is accumulated and becomes will be determined inside each interval, discharge the graph that rise with post, also be called histogram.

气候直方图是将所收集的降水量测定值，分为几个相等的区间作为横轴，并将各区间内所测定值依所出现的次数累积而成的面积，用柱子排起来的图形，也叫做柱状图。