角化不全

Further, it is intended to provide an external composition for skin in which a compound having such a function is blended.

本发明提供的是含有选自α-氨基酸衍生物及其盐中的一种或两种以上化合物的角化不全抑制剂、毛孔收缩剂或皮肤粗糙防止/改善剂。

Hyperkeratosis or parakeratosis on an otherwise negative Pap smear is not a marker for significant CIN and may be related to infection or trauma with inflammation, such as from use of a diaphragm .

在其他的巴氏涂片阴性的片子上的过度角化或角化不全，这种情况可能与感染相关，也可能与感染合并血肿相关，，如使用隔膜。

Hyperkeratosis or parakeratosis on an otherwise negative Papsmear is not a marker for significant CIN and may be related toinfection or trauma with inflammation, such as from use of a diaphragm .

在其他的巴氏涂片阴性的片子上的过度角化或角化不全，这种情况可能与感染相关，也可能与感染合并血肿相关，，如使用隔膜。

Main HPV7(9/18) positive samples\' pathology manifestations matched the characteristics for HPV7 infection,which showed papillomatosis and acanthosis,deep-stained cells including keratohyalin granules in middle size,and obvious hyperkeratosis and parakertosis.

HPV7阳性(18份)的病理象特征：(1)乳头瘤样增生和棘层肥厚；(2)内含中等大小的透明角质颗粒的细胞深染；(3)显著的角化过度和角化不全。

It was found that there was a close relationship between the amount of PMN infiltration and the mitotic index of epidermal cells or the amount of parakeratosis.

发现了银屑病表皮细胞有丝分裂指数或角化不全的细胞数量分别与多形核白细胞浸润数量之间存在着密切的关系。

The parakeratosis inhibitor, pore-shrinking agent or agent for preventing/ameliorating rough skin comprises one or more compounds selected from the group consisting of alpha-amino acid derivatives and salts thereof.

本发明进一步提供含有作为上述角化不全抑制剂、毛孔收缩剂或皮肤粗糙防止/改善剂的选自α-氨基酸衍生物及其盐中的一种或两种以上化合物的皮肤外用组合物。

Fig2 Histological changes of the grafts from control group4wk after transplantation,showed retaining parakeratosis,hyperk-eratosis and acanthosis etc ×200

图2 移植后4wk对照组移植皮片组织学改变，示保留角化过度、角化不全、棘层肥厚等略

The invention provides a parakeratosis inhibitor, a pore-shrinking agent or an agent for preventing/ameliorating rough skin which has a function of inhibiting parakeratosis, shrinking a pore, preventing/ameliorating rough skin or the like, does not have any safety problem such as sensible irritation and has high safety.

本发明提供具有抑制角化不全、收缩毛孔、防止/改善皮肤粗糙等功能，在刺激感觉等安全性上没有问题，安全性高的角化不全抑制剂、毛孔收缩剂或皮肤粗糙防止/改善剂，本发明还提供配合具有上述功能的化合物的皮肤外用组合物。

Fig3 Histological changes of the grafts from AK auto Ab group4wk after transplantation,showed acanthosis was reduced,parakeratosis and hyperkeratosis was disappeared ×200

图3 移植后4wk AK auto Ab注射组移植皮片组织学改变，示棘层肥厚变轻，角化过度、角化不全消失略

There is also in the skin lesions of psoriasis immune globulin, complement, anti-IsA factor, anti-keratin antibodies and parakeratotic nuclei antibody, etc., these factors result in abnormal T lymphocytes in the immune cycle of separatist injury and the number of T lymphocytes in significantly reduced, such as the Con A stimulus-response is reduced, while phytohemagglutinin and pokeweed mitogen factor is a normal reaction, this phenomenon is to support T-cell subsets flawed.

在牛皮癣的皮损中还有免疫球蛋白、补体、抗IsA因子、抗角蛋白抗体及角化不全细胞核中有抗体等，这些免疫异常因子造成T淋巴细胞的周期分裂性损伤和T淋巴细胞数量明显减少，如对刀豆球蛋白的刺激反应性下降，而对植物血凝素和商陆有丝分裂因子却反应正常，这种现象支持T细胞亚群存在缺陷。

On the other hand, the more important thing is because the urban housing is a kind of heterogeneity products.

另一方面，更重要的是由于城市住房是一种异质性产品。

Climate histogram is the fall that collects place measure calm value, cent serves as cross axle for a few equal interval, the area that the frequency that the value appears according to place is accumulated and becomes will be determined inside each interval, discharge the graph that rise with post, also be called histogram.

气候直方图是将所收集的降水量测定值，分为几个相等的区间作为横轴，并将各区间内所测定值依所出现的次数累积而成的面积，用柱子排起来的图形，也叫做柱状图。