西蒙娜

Antigene peptide nucleic acid specifically inhibits MYCN expression in human neuroblastoma cells leading to cell growth inhibition and apoptosis Roberto Tonelli,Stefania Purgato,Consuelo Camerin,Raffaele Fronza,Fabrizio Bologna,Simone Alboresi,Monica Franzoni,Roberto Corradini,Stefano Sforza,Andrea Faccini,Jason M. Shohet,Rosangela Marchelli,and Andrea Pession Department of Pediatrics, University of Bologna,Sant'Orsola-Malpighi Hospital, Bologna, Italy; Department of Organic and Industrial Chemistry, University of Parma, Parma,Italy; and 3Center for Cell and Gene Therapy, Texas Children's Cancer Center, Baylor College of Medicine, Houston, Texas Abstract We developed an antigene peptide nucleic acid for selective inhibition of MYCN transcription in neuroblastoma cells, targeted against a unique sequence in the antisense DNA strand of exon 2 of MYCN and linked at its NH2 terminus to a nuclear localization signal peptide.

抗原肽核酸抑制MYCN具体表达的神经母细胞瘤细胞，导致细胞生长的抑制和凋亡罗伯托利，斯特凡Purgato ，苏埃洛卡默琳，拉菲尔Fronza ，梅奥尼博洛尼亚，西蒙娜Alboresi ，莫妮卡弗兰索尼，罗伯托Corradini ，斯特凡诺斯福尔扎，安德烈Faccini ，杰森先生Shohet ， Rosangela Marchelli ，和安德烈Pession儿科，博洛尼亚大学，圣' Orsola -马尔皮基医院，博洛尼亚，意大利；有机部和工业大学化学帕尔马，帕尔马，意大利和3Center的细胞和基因治疗，德州儿童癌症中心， Baylor医学院，得克萨斯州休斯敦摘要我们开发了一种抗原肽核酸的选择性抑制神经母细胞瘤MYCN转录细胞，针对一个独特的序列反义DNA链的第2外显子，并与在MYCN 其氨基端为核定位信号肽。

The duchess plays the courtesan in her own house and this disgusts Beaurivage and makes him amend his way.

西蒙娜逃走时，博尔德纳夫还气冲冲地喊道：这一棍你就受着吧，他妈的！

Not at all. It was the very serious Simone de Beauvoir who explained that Brigitte Bardot's contribution to the French economy was almost exactly the same as the export value of the Renault Dauphine.

当然不是。这是非常严重的西蒙娜德波伏瓦谁解释说，碧姬巴铎的贡献，法国经济几乎完全一样的雷诺多菲出口价值。

Greater portions of this apocryphon are translated in the so-called "Actus Petri cum Simone", and likewise in Sahidic and Slavonic, Arabic, and Ethiopic versions.

大部份这apocryphon翻译所谓的"现实的Petri暨西蒙娜"，同样在Sahidic和斯拉夫语，阿拉伯语，和埃塞俄比亚的版本。

Simonne flung a fur-lined pelisse briskly over her shoulders and went out.

西蒙娜匆匆把一件皮袄往肩上一披，就出去了。

I am thinking of the fanatical asceticism of Simone Weil's life, her contempt for pleasure and for happiness, her noble and ridiculous political gestures, her elaborate self-denials, her tireless courting of affliction; and I do not exclude her homeliness, her physical clumsiness, her migraines, her tuberculosis.

我现在正在思考这样一系列问题：西蒙娜·薇依狂热的禁欲主义生活方式，她对愉悦和幸福的蔑视，她高尚而可笑的政治姿态，她的偏头痛，她的肺结核。

"Ah, it's you, Mademoiselle Simonne! What can I do for you?"

"哟！是你呀，西蒙娜小姐，你有什么事吗？"

This allowed Ometto to break away at the front and he was able to pull out a commanding lead to win by 7 laps ahead of Simone Zanon in 2nd and Massimo Poldi in 3rd, all driving the Mantua, which in fact took the first 7 positions in the final.

这使Ometto打破在前面，他能够拉了领先赢得了7圈提前西蒙娜Zanon在第2和马西莫波尔蒂在第三，所有驾驶曼图亚，事实上在第一次在7个职位最后。

The principal value of the collection is simply that anything from Simone Weil's pen is worth reading.

这部文集首要的价值很简单：凡是出于西蒙娜·薇依手笔的文字都值得一读。

Yet the person of Simone Weil is here as surely as in any of her other books—the person who is excruciatingly identical with her ideas, the person who is rightly regarded as one of the most uncompromising and troubling witnesses to the modern travail of the spirit.

其实，在这里的西蒙娜·薇依与在她其它著作中西蒙娜·薇依并无二致——一个承受着精神折磨的人，一个被公认为这个痛苦的时代最不妥协而又最病态的证人之一的人。

In the United States, chronic alcoholism and hepatitis C are the most common ones.

在美国，慢性酒精中毒，肝炎是最常见的。

If you have any questions, you can contact me anytime.

如果有任何问题，你可以随时联系我。