西他

Bobby, Bitsy, this is my boyfriend, Marcus.

巴比，贝西他是我男朋友马可斯

Results Stable drug-resistant SW1990/GZ cell strain was established by culturing with gemcitabine for 9 months. The morphology and growth characteristics of the cell strain changed remarkably. The cells shrinked and became rounder; its endoplasm expanded; granular substances increased; and the doubling-time was prolonged. Resistance of the cell line to gemcitabine, fluorouracil, adriamycin, and mitomycin significantly increased. The TrxR activity of the drug-resistant cells was increased markedly.

结果 药物培养9个月后，得到稳定传代的SW1990/GZ耐药细胞株；其形态学、生长特征等均发生了明显变化，细胞变圆、体积缩小、内质网扩张、颗粒样物质增多及细胞倍增时间延长；对吉西他滨、5-氟尿嘧啶、阿霉素和丝裂霉素的耐药性均显著增加；耐药细胞的TrxR活性也明显增高。

Plasma concentrations of gemcitabine were measured by ion-pair reversed-phase high-performance liquid chromatography.

采用离子对反相高效液相色谱法测定吉西他滨血药浓度。

The major toxicities were leucopenia and thrombocytopenia.Conclusion It is suggested that GEM combination DDP chemotherapy advanced NSCLC are more effective.

吉西他滨联合顺铂治疗晚期非小细胞肺癌的疗效是较高的。

Objective: To evaluate the efficacy and toxicity of Gemcitabine for malignancy in the elderly.

目的：评价吉西他滨治疗老年人恶性肿瘤的疗效和毒副作用。

Objective: To study the growth inhibition and radiosensitivity effect of Gemcitabine on non-small cell lung cancer cells.

目的：研究吉西他滨对体外培养非小细胞肺癌细胞的细胞周期改变和凋亡影响，及其放疗增敏的作用及机制。

Objective To establish gemcitabine-resistant pancreatic cancer cell strain and study the role of thioredoxin reductase in drug-resistant process.

目的 建立对吉西他宾耐药的胰腺癌细胞株，探讨硫氧还蛋白还原酶在耐药过程中的作用。

MethodsA subline of human pancreatic cancer cell line MIAPaCa2 (MIAPaCa23) with high liver metastasis potential was selected and injected through the tail vein to establish a pancreatic cancer model in nude mice with high liver metastasis. The capability of invasion in vitro was evaluated by a transwell chamber system.

方法筛选出高肝转移的胰腺癌细胞亚型MIAPaCa23，用Transwell小室模型观察PESV对MIAPaCa23细胞体外侵袭能力的影响；尾静脉注射MIAPaCa23细胞建立高肝转移率的裸鼠胰腺癌模型，对比PESV和化疗药物吉西他滨以及抗血管生成剂TNP470对裸鼠胰腺癌肝转移的抑制作用。

AIM: To study inhibitory effect on proliferation of docetaxel on murine angiosarcoma cell line (ISOS-1) and compare with etoposide.

目的：探讨多西他赛抑制小鼠血管肉瘤细胞株ISOS-1增殖的作用，并与依托泊苷进行比较。

As a new miazines crystallose,gemcitabine has unique antineoplastic activity against many kinds of solid tumor,especially non-small cell lung cancer,pancreatic cancer and breast cancer.

吉西他滨作为一种新型嘧啶类抗代谢剂，对多种实体瘤尤其是非小细胞肺癌、胰腺癌、乳腺癌、膀胱癌等具有独特的抗瘤活性。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。