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The 20S catalytic core of the 26S proteasome has the shape of a barrel made of four rings which are composed of seven differentαsubunitsα_1-α_7 at two outer rings and seven differentβsubunitsβ_1-β_7 at two inner rings at which the catalytic sites locate. Three of theβsubunits contain proteolyses sites, which are sequestered in the hollow interior of the 20S particle. Substrates enter the 20S through a narrow channel formed by theβsubunits, whose N-termini, depending on their conformation, can either obstruct or allow substrate entry and thus function as a gate. This entry channel is narrow and only permits passage of unfolded, linearized polypeptides.

哺乳动物26S蛋白酶体是由一个20S催化颗粒(catalytic particle,CP)和两个19S调节颗粒(regulatory particle,RP)组成的ATP(adenosine-triphosphate,ATP)依赖性蛋白水解酶复合体。20S CP是26S蛋白酶体的催化核心,它是由4个圆环堆叠形成的桶状复合物,其中两侧外环每个环是由α_1-α_7亚基组成,两个内环每个环是由β_1-β_7亚基组成,4个环的中央形成一个狭窄的内腔。2个β内环形成了20S CP的催化中心空腔,其内壁为催化活性位点所在地;外侧α环中心的孔道是底物到达催化中心空腔的通道,一般被α亚基上的N末端所封闭,阻止胞内非目的靶蛋白进入20S CP内被降解破坏。

So he and three students sneaked back in during a long weekend holiday when he knew the gatekeepers might be off duty.

为什么一个医生要冒着被抓被打的危险,去发掘和阻止这个绝症在中国的快速蔓延呢?

Eacute;owyn: A cage. To stay behind bars until use and old age accept them. And all chance of valor has gone beyond recall or desire.

伊欧温:被困在牢笼里,被界限禁锢直到垂老才接受这种生活,所有证明我的英勇的机会都被取消和阻止。

To stay behind bars until use and old age accept them. And all chance of valor has gone beyond recall or desire.Aragorn: You're a daughter of Kings.

伊欧温:被困在牢笼里,被界限禁锢直到垂老才接受这种生活,所有证明我的英勇的机会都被取消和阻止。

ZL03 2 354312.The innovations include: automatic self-closing and reliably sealed valve structure: the design of duplex valve clack with pilot valve to tackle the problem of reverse seal structured valve being difficult to be opened; an automatic drain control device to automatically drain the remaining water from the hydrant; protective plate provided between the hydrant body and the valve block to serve as a connection between the hydrant body and the valve block, which is the first one to be damaged when the ground hydrant is clashed, and prevent pulling-off of the whole above-ground part of the fire hydrant, so as to properly protect the main parts from any damage. The self-closing and reliably sealed valve now prevents drain of water, and only the damaged protective plate is needed to be replaced before immediate re-operation. Thus the repair work after clashing is very easy and simple.

其创新点为:具有能自动关闭并可靠密封的阀门结构:采用有先导阀复式结构阀瓣设计,解决反向密封结构阀门开启沉重费力的难题;设计自控排水装置,能自动排除栓体内余水;在栓体和阀体之间设计撞裂板,它既起到连接栓体和阀体的中介作用,又可在地上消火栓被撞击时率先破裂毁坏,并使露出地面的栓体不见整体脱落,有效保护各主体部件的完好无损,而此时阀门的自闭式结构可靠密封阀门阻止水源外泄,修复时只需更换损坏的撞裂板即可立即复位投入使用,使被撞后的修复工作变得十分轻松简便。

A single deselect cannot be performed when Select All has been used.

一阻止不能够被运行再次当选当选择已经全部被用的时候。

There are any number of ways that she could have gotten to Manhattan: an unblocked tunnel, a boat, a swing bridge or drawbridge that had been merely retracted and not destroyed. The quarantine certainly couldn't have stopped her, since humanity had already been wiped out.

她有很多种方式来到曼哈顿岛:一条没被封锁的隧道,一艘船,平旋桥或是一座只是被收拢而未被摧毁的吊桥,在人类已经被毁灭了的情况下,隔离当然阻止不了她。

Logical consistency required that this interpretation should be carried farther; and Marcellus, who was never deterred by any considerations of prudence, took this bold step.

逻辑的一致性要求这样的解释被带往前去,而马西流从来没有被深思熟虑所阻止,他走了大胆的一步。

The first guard line is a proactive intrusion response method based on intrusion graph, which can make proactive reactions in the forepart in order to prevent the final attacking goals from realizing, furthermore, to protect systems security. The second guard line is an intrusion response method based on damage containment techniques. This guard line will contain damaged data quickly and precisely, then release correct data contained mistakenly just now, which can maintain basic service functions for legal users even though intrusion response has been disabled.

一方面,利用基于入侵攻击图的先应式入侵响应方法,在检测到入侵行为的前期进行防御,在入侵者的攻击目的完全实现之前给予响应,尽量阻止其攻击目的的实现,并采用博弈方法进行策略分析,使系统的响应成本达到最低;同时利用基于数据破坏隔离技术的入侵响应方法作为第二道防线,在前期的入侵响应失效、关键数据已经被破坏的情况下,利用破坏隔离技术精确定位被破坏的数据并迅速释放被误隔离的数据,最大限度地提高数据利用率,从而保证系统向用户提供不问断的服务。

However, as time goes by, new anti- reversing techniques are constantly added into packers to prevent reversers from analyzing the protected executable and preventing a successful unpack.

然而,随着时间的推移,新的反逆向技术不断的被应用到加壳软件中,来阻止逆向者们分析被保护的程序和防止程序被成功脱壳。

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We have no common name for a mime of Sophron or Xenarchus and a Socratic Conversation; and we should still be without one even if the imitation in the two instances were in trimeters or elegiacs or some other kind of verse--though it is the way with people to tack on 'poet' to the name of a metre, and talk of elegiac-poets and epic-poets, thinking that they call them poets not by reason of the imitative nature of their work, but indiscriminately by reason of the metre they write in.

索夫农 、森那库斯和苏格拉底式的对话采用的模仿没有一个公共的名称;三音步诗、挽歌体或其他类型的诗的模仿也没有——人们把&诗人&这一名词和格律名称结合到一起,称之为挽歌体诗人或者史诗诗人,他们被称为诗人,似乎只是因为遵守格律写作,而非他们作品的模仿本质。

The relationship between communicative competence and grammar teaching should be that of the ends and the means.

交际能力和语法的关系应该是目标与途径的关系。

This is not paper type of business,it's people business,with such huge money involved.

这不是纸上谈兵式的交易,这是人与人的业务,而且涉及金额巨大。