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In mammals the Notch gene family comprise four related genes, Notch1-4, as the Notch ligands that encode transmembrane proteins. Ligand-receptor interaction mediated Notch activation ultimately leads to the conversion of effectors-CSL CBF1, Su(H, Lag-1 proteins, from repressors to transcriptional activators, and subsequent up-regulation of downstream targets.

在哺乳动物中,Notch基因家族包含了4个相关的基因,分别为Notch-1至-4,和Notch受质蛋白一样能被转译成膜蛋白;受质-受体间相互作用所引起Notch受体蛋白的活化会促使作用蛋白-CSL CBF1, Su(H, Lag-1 蛋白扮演抑制分子或者是转录活化分子上的角色改变,并且进一步地正向调节下游的标的基因。

On the regulatory front, we were outgunned on two big issues.

在规章调节方面,我们被两个大难题上击败了。

Certain versions are equipped with a height and lumbar adjustable driver's seat which enables the ideal driving position to be found, while the driver can get more comfortable by the height adjustable steering wheel and ergonomically-positioned steering wheel-mounted controls.

某些版本都装备了高度和腰椎调节驾驶员座椅使理想的驾驶位置被发现,而驾驶者可以得到更多的高度可调方向盘舒适和人体工程学定位方向盘上的控制。

Because of the complexity of these chips, which can also be used to manage voltage and sense temperature, their design is sometimes described as a 'black art.

这种还能模拟芯片能用来调节电压和传感器的温度的芯片相当复杂,其设计常常被称为是一门&黑色艺术&。

Based on the traffic model of a single node and on the system stability criterion, it is shown that the PD controller can regulate the source rate on the basis of the knowledge of buffer occupancy of the destination node in such a manner that the congestion-controlled network is asymptotically stable without oscillation in terms of the buffer occupancy of the destination node.

在单个节点的交通流的模型基础上,运用控制理论中系统稳定性分析方法,讨论如何利用信终端节点缓冲占有量的比例加微分的反馈形式来调节信源节点的能控交通流的输入速率,从而使被控网络节点的缓冲占有量趋于稳定。

Hexokinse is inhibited by glucose 6-phosphate which builds up after PFKis inhibited.Pyruvate kinase is activated by fructose 1,6-bisphosphate but allosterically inhibited by ATP and alanine. Like PFK,it is also regulated hormonally by glucagon.

己糖既没被 PFK 受到抑制后积累的葡萄糖 6-磷酸激活,但受到 ATP 和丙氨酸的别构抑制;像 PFK 一样,它也受到胰高血糖素的调节。

These behaviors are thought to result from impairments in brain systems that regulate behavior.

这些行为被认为是由于调节行为的大脑系统受损所致。

Therapeutic horseback riding have been believed as a good media to improve balance ability. We proceeded to do a case study, by the use of a mechanical horse made by Joba EU-6441, Matsushita Electric Industrial Co., Ltd., Japan. This mechanical horse is designed according to the movement pattern of a real horse. The seat is designed to move in a pattern based on the figure of eight. Many clinics begin to adopt the mechanical horses as treatment tools, but its effectiveness in children with ADHD remains unknown.

目前对於ADHD儿童平衡能力的训练及介入成效之研究较少,本研究以骑马治疗进行个案讨论,采用的骑马机(Joba EU-6441, Matsushita Electric Industrial Co。, Ltd。, Japan)是根据真实马运动时的动作模式所设计出来的,临床上认为骑马机有可增进平衡能力的功用,目前已逐渐被临床治疗师广泛使用,但对於骑马机的确切疗效仍没有研究加以证实,尤其是骑马机是否对於平衡能力或是感觉调节能力有所帮助等。

The enzymatic activity of PHDs is O2-dependent so PHDs are believed to be oxygen sensors as well as tumor suppressors.

的降解。由于PHD的酶活性严格受氧气浓度的调节,因而被认为是机体的氧气感受器。

The ratio of final baryon to meson and baryon antibaryon correlation in e +e - annihilation are considered as sensitive observables to test the hadronizition models,because among the results obtainted in different popular hadronizition models,only those from JETSET event generator can fit experimental data by adjusting extra ad hoc parameters.

在e+e-→h′s反应中,末态重子介子比及重子反重子关联,在流行的强子化模型中,仅有JETSET事件发生器能通过调节专用附加参数较好拟合实验,被认为是检验强子化模型的最敏感可观察量。

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