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The conclusions can be drawn through numerical simulation: The hydrate-forming region becomes small with increasing circulation rate and inhibiter concentration, and it is possible to make the hydrate-forming region away from sea floor by increasing circulation rate and inhibiter concentration, thus preventing blowout preventer lines from hydrate plugging; the decrease in gas volume fraction in the annulus due to hydrate formation reduces pit gain, which can delay the detection of well kick; the possibility of hydrate presence at a relatively low gas production rate is much greater than that at a relatively higher production rate; the bottom hole pressure is affected little by hydrate phase transition, and it is allowable not to consider hydrate phase transition when the bottom hole pressure is calculated; shut-in casing pressure cann't truly reflect gas kick due to hydrate formation and the situation is getting worse with time

模拟计算结果表明:溢流期间,天然气水合物的生成区域会随着循环流量的增大或抑制剂浓度的提高而减小,可通过增大流量和抑制剂浓度使水合物的生成区域脱离海底,减小防喷器管线被堵塞的危险;水合物的生成使环空中气体体积分数降低,泥浆池增量减小,给溢流检测带来延迟;当检测到有气侵发生时,水合物藏分解速率比较小时,井筒中生成水合物的可能性要比分解速率大的情况下更为严重;水合物相变对井底压力的影响较小,在工程中计算井底压力时可以忽略;由于天然气水合物的生成使得关井套压值不能真实反应气侵情况,而且随着时间的增加情况会更加严重。

Objective To explore livin, MTA1 and the caspase3 protein expression, their correlation and clinical pathology in colon cancer Methods The expressions of livin, MTA1 and caspase3 protein in 88 cases of colon cancer were detected by immunohistochemistry stainingResults Livin, caspase3 protein and MTA1 positive expression rates in colon cancer tissues were more than those in tissues beside the cancer Furthermore there were obvious relevance between livin protein, MTA1 positive expression rate and degree of histodifferentiation and lymph node metabasis and between caspase3 protein positive expression rate and degree of histodifferentiation of colon cancer Caspase3 protein expression had prominent inverse correlation with the livin expressionConclusions ①Over expression of livin having inhibtion on colon cancer is one of important factors of colon carcinogenesis ②Caspase3 protein expression in colon cancer tissues is inhibited to less and has prominent inverse correlation with livin expression Accordingly, suppressing caspase3 protein activity is one of channels, by which livin promotes colon carcinogenesis ③MTA1 plays the important role in histodifferentiation degree and lymph node metastasis of colon cancer

采用免疫组织化学染色方法检测88例结肠癌组织中Livin,Caspase3 及MTA1的表达情况。结果(1)结肠癌组织中Livin的阳性表达率显著高于癌旁组织,且Livin的表达与结肠癌的组织分化程度及淋巴结转移程度显著相关。(2)结肠癌组织中Caspase3蛋白的阳性表达率显著高于癌旁组织,且Caspase3蛋白的表达与结肠癌的组织分化程度显著相关。(3)结肠癌组织中MTA1的阳性表达率显著高于癌旁组织,且MTA1的表达与结肠癌的组织分化程度及淋巴结转移程度显著相关。(4)Caspase3蛋白的表达又与Livin的表达呈显著负相关。结论(1)Livin在结肠癌组织中过表达,它可能是促进结肠癌发生的重要因素之一。(2)Caspase3蛋白在结肠癌组织中表达被抑制而降低,且与Livin的表达呈负相关。因此,抑制Caspase3蛋白的活性是Livin促进结肠癌发生的途径之一。(3)MTA1对结肠癌的组织分化及淋巴转移发挥重要作用。

Mortimer says Plantagenet's father was once in line to the throne and had raised an army to help him claim his right to power, but he was captured and executed, while the rest of the Mortimer line, including this Mortimer, was suppressed.

莫蒂默说普朗塔的父亲曾是一致的王位,并提出了军队,以帮助他声称他的权利,权力,但他被逮捕和处决,其余的莫蒂默线,包括本莫蒂默,被抑制。

This is Semler's second pharmacy where he was able to practice what he preached.

我很高兴,因为在那里,我的良心不会被亵渎,我的信仰不会在每天早上出门的时候被抑制。

In these instances, growth is allowed to continue unhampered for a slightly longer time than is common, or it may be inhibited at a slightly earlier period.

在这些实例里,发展被允许继续下去而未受阻,稍微有点长的时间比是普通的,或者它可能被抑制在一个稍微有点早期的时期。

Knockdown of the gene blocked neural differentiation and the effect was rescued by the wild-type human gene, and not by a catalytically inactive mutant.

研究还发现,KDM7A表达抑制所引起的干细胞神经分化受阻现象可被FGF4的过表达所逆转,表明FGF4作为被KDM7A调控的基因介导了KDM7A在胚胎干细胞神经分化中的功能。

Furthermore, we found that the Sema3F-triggered growth cone attraction was abolished by inhibition of the cGMP signaling pathway but not by inhibition of the cAMP signaling pathway, and the attraction was suppressed when elevating the intracellular cGMP level.

而且,在组织块共培养中,分泌Sema3F的细胞团能使小脑颗粒细胞偏向它迁移。我们发现Sema3F的吸引性作用在cGMP信号通路被抑制时受阻断,在细胞内cGMP水平增加时被削弱。

The results indicated that paraquat had a significant effect on soil microflora in thirty days. Paraquat of 0.05~5mg/kg inhibited the growth of funguses, but stimulated the growth of the population of cellulose utilizing microorganism and nitrifying bacteria. The low-density paraquat stimulated the growth of bacteria and actinomyces, but high-density paraquat inhibited their growth.

结果表明,施用百草枯对土壤微生物有明显的影响。0.05~5mg/kg的百草枯在施药后30d内,真菌种群严重被抑制;硝化细菌种群和纤维素分解菌种群均呈刺激效应;低浓度的百草枯刺激土壤细菌和放线菌种群的生长,而高浓度的百草枯则抑制其生长。

At the early stage of stress (2 d and 5 d), the Pn, Tr, Ci and Gs of own-root plant were significantly decreased, while Ls was significantly increased, the inhibition of photosynthesis of own-root plant was mainly caused by stomatal factor, water use efficiency was significantly elevated, resulting from lower Pn.

在NaCl胁迫下,自根苗和嫁接苗叶片和根系中酶(SOD、POD、CAT和APX)活性和抗氧化剂含量发生明显变化,或被诱导上升,或被抑制下降,但嫁接苗各指标均显著高于自根苗,而丙二醛含量显著低于自根苗,表现出较强的抗氧化能力。

The 94-kDa GLase activity was Ca++ dependent, showed maximal activity in the pH 6-8, their activity was inhibited in the presence of 1,10-phenanthroline, and their proenzymes were cleaved and activated after incubation with organomercurial compounds and trypsin.

72kDa蛋白脢,出现於所有检体,包括未被感染的老鼠,94kDa蛋白脢只出现於广东住血线虫感染老鼠脑部。94kDa蛋白脢活性是一种钙离子依赖性,在pH值6-8时具最大活性,在 1,10-phenanthroline存在下,其活性受到抑制,此蛋白酵素元会被有机汞类及胰蛋白脢切断并活化。

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Neither the killing of Mr Zarqawi nor any breakthrough on the political front will stop the insurgency and the fratricidal murders in their tracks.

在对危险的南部地区访问时,他斥责什叶派民兵领导人对中央集权的挑衅行为。

In fact,I've got him on the satellite mobile right now.

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