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Quinidine, an established inhibitor of CYP2D6, was used as the positive control.

奎尼丁,一个已经被证实对 CYP2D6抑制的化合物,被用来作为正面对照。

Yam steroid saponins and sapogenin are resulting in MCF-7 cells apoptosis by arrested the G0/G1 phase, increased the p53 protein with promoting apoptosis and decreased the AKT protein with anti-apoptosis and the BRCA-1 protein with repairing DNA. And, SPG has the excellent anti-cancer effect on MCF-7 cells may be due to induced much of the p53 protein in the early treated stage.

进一步的研究发现,山药固醇类皂及皂元抑制MCF-7乳癌细胞的功效,主要是诱发G0/G1期停滞,造成细胞凋亡;其透过的机制是经由p53促凋亡蛋白的增加,及AKT与BRCA-1等抗凋亡蛋白被抑制,达到双重细胞凋亡之抗癌效果;其中SPG处理之MCF-7肺癌细胞具早期大量诱发p53蛋白的特性,或许是SPG优异抗癌效果之原因。

The identified dopamine neurons were inhibited by the aversive stimulus.

那些被鉴定的多巴胺能神经元确实被刺激所抑制。

The application of such solvent effects to the kinetically controlled peptide synthesis, however, has only recently been exploited.

试验结果表明,在所研究的几种单相共溶剂体系中,木瓜蛋白酶的酰胺酶活性都得到了不同程度的抑制,有些情况下甚至完全被抑制,而酯酶活性则保留了单水相中的全部或部分。

The proliferation of MCF-7 and MDA-MB-231 cells was inhibited by evodiamine and rutaecarpine with time expansion and drug concentration by MTT assay.

结果发现MCF-7和MDA-MB-231的细胞增生会随著吴茱萸碱和吴茱萸次碱剂量的增加和作用时间的延长而被抑制,而且吴茱萸碱比吴茱萸次碱对於乳癌细胞的增生有更强的抑制效果。

One problem existing in side-lobe blanking is that when pulse-type clutters fill in the whole range channel, the blanker suppresses not only the clutters but the target signals as well, thus loses its detection ability.

旁瓣消隐技术在使用中存在的一个问题是:当从旁瓣进入的脉冲式杂波干扰充满整个距离通道时,旁瓣消隐器在抑制干扰的同时,也使目标信号被抑制,从而失去对目标的探测能力。

Hatred is so repulsive to most humans that it is repressed into the unconscious where it acts out causing disease instead of violence.

仇恨是如此被绝大多数人类所排斥,它被抑制入无意识,在那里它的作用导致了疾病,而不是暴力。

Bitter compounds in saliva activate particular T2R/TRB isoforms activate gustducin heterotimers, activated α-gustducin stimulates PDE to hydrolyze cAMP, the decreased cAMP may disinhibit cyclic nucleotide-inhibited channels to elevate intracellular Ca2+.

唾液中的苦味化合物激活T2R/TRB同型体,这种激活导致味导素异聚体的激活,被激活的α-味导素又激活PDE,PDE水解cAMP,cAMP水平的降低使环核苷酸抑制的阳离子通道去抑制,从而使细胞内Ca2+升高。

Salty and sour directly transduction by apical channels that are non-gated channel or chemically-gated channel. Bitter compounds in saliva activate particular T2R/TRB isoforms which activate gustducin heterotimers, activated α-gustducin stimulates PDE to hydrolyze cAMP, the decreased cAMP may disinhibit cyclic nucleotide-inhibited channels to elevate intracellular Ca2+.

咸和酸直接通过顶部非门控或化学门控离子通道转导唾液中的苦味化合物激活T2R/TRB同型体,激活导致味导素异聚体的激活,被激活的α-味导素又激活PDE,PDE水解cAMP,cAMP水平的降低使环核苷酸抑制的阳离子通道去抑制,从而使细胞内Ca2+升高。

Bitter compounds in saliva activate particular T2R/TRB isoforms which activate gustducin heterotimers, activated α-gustducin stimulates PDE to hydrolyze cAMP, the decreased cAMP may disinhibit cyclic nucleotide-inhibited channels to elevate intracellular Ca2+.

唾液中的苦味化合物激活T2R/TRB同型体,这种激活导致味导素异聚体的激活,被激活的α-味导素又激活PDE,PDE水解cAMP,cAMP水平的降低使环核苷酸抑制的阳离子通道去抑制,从而使细胞内Ca2+升高。

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