被抑制的

Wood Vinegar is a natural material that is distilled from wood. It is compose of organic acid and hydroxybenzene , Various dosage of wood vinegars, pyrolignerous acid and guaiacol were mixed into organic manure firstly in this experiment, and then, the above said organic manure are separately added into soil. Under the analysis of the amount of the edaphon, adding 10g wood vinegar to 1kg organic manure and 30kg soil can much active the edaphon effectively in a short term and make a maximum rising extent of edaphon numbers.

木醋液是从多年生柞木中经过高温蒸馏出来的纯天然物质，其主要成分是有机酸和酚类物质，为了明确木醋液和主要成分对土壤微生物的作用，将加入不同剂量的木醋液、愈创木酚、醋酸的有机肥施入土壤，观察土壤中微生物数量的变化，结果表明：在1kg有机肥中加入10g木醋液，施入30kg土壤中，土壤微生物数量增加幅度最大，土壤微生物10d内被有效地激活；同时，当在1kg有机肥中木醋液的添加量高达50g时，对土壤微生物有一定的抑制作用。

This paper describes a new algorithm of image enhancement of impulse noise based on PCNN time matrix and rough sets indiscernibility relation. For noisy gray images, the results of computer simulations show that the image noise can be reduced efficiently and the image becomes clear and the target details of the image can be enhanced better by using this algorithm. In addition, the effects of this algorithm are better than usual image enhancement algorithm.

基于粗集理论中的不可分辨关系的等价概念及PCNN赋时矩阵，提出了一种含有脉冲噪声的图像增强算法，计算机仿真结果表明，对被噪声污染的灰度图像，用基于PCNN与粗集理论相结合的图像增强算法处理后，图像噪声得到有效抑制，画面更清晰，图像中目标的细节也得到了很好的增强，其结果优于常规方法。

Most patients' death arise from the metastatic spread of primary tumors There is an urgent need for the finding of novel anti-tumor and anti–metastatic drugs to improve the quality of life and survival rate of patents Justicia procumbens is an herb and used to reduce fever inflammation and canker in Taiwan We've detected that 0 3 μM JA could effectively inhibit the proliferation of oral cancer cells OC-2 and HSC3 but not normal oral keratinocytes in MTS assay JA-treated OC2 underwent apoptosis as suggested by increased sub-G1 DNA contents condensed nuclear morphologh and DNA fragmentiation The migration activity of OC-2 was also significantly reduced by treatment with low concentration of JA The expression of ?

大部分的口腔癌病患死於原位癌的转移和扩散，寻找有效抗癌和抗转移的药物疗法来增进病患的生活品质和存活率，对治疗口腔癌而言非常重要。爵床草是台湾民间常用草药，常被用来消炎止热和治疗口疮、乳瘤。我们利用MTS分析，发现处以0 3 μM的JA 48小时，即可有效抑制口腔癌细胞OC-2和HSC3的增生，但不影响正常口腔上皮细胞生长。OC-2经JA处理后，其sub-G1的DNA含量增加，并可观察到DNA固缩和梯度断裂的现象，说明JA可使OC-2走向细胞凋亡。除此之外，0 3 μM的JA亦可有效降低OC-2的迁移能力。

Light microscope and transmission electron microscopy showed that SMMC-7721 cells induced by SAHA had undergone the restorational alteration in morphology and ultrastructure, which were different from those of nontreated cells but were similar to those of normal cells, and the changes were as follows: the cells turned to be flat and spread; the nucleo-cytoplasmic ratio lessened and nuclear shape became rather regular; the number of nucleolus reduced and its volume lessened; euchromatin increased while heterochromatin decreased in nucleus; in the cytoplasm, mitochondria grew in number with relatively consistent structure and well-developed mitochondria cristae; Golgi complex turned to be well-developed and typical; rough endoplasmic reticulum increased. Immunocytochemistry assay showed that the expression of AFP and PCNA were declined significantly. FCM analysis showed SAHA could arrest SMMC-7721 cells in G0/G1 phase, with an accumulation of the cells in G0/G1 phase while a decrease of cells in S phase. Semi-quantitative RT-PCR detection revealed that the expression of p21WAFl mRNA was upregulated remarkably in the cells treated with SAHA.

结果：倒置显微镜和透射电镜观察显示，经SAHA处理的细胞增殖速度显著减慢，细胞体积增大，细胞核较小，形状较为规则，核仁数量减少、体积变小，核内常染色质增多而异染色质减少，核质比例减小，细胞质内线粒体数量增多、线粒体嵴发达，高尔基体较为典型，粗糙型内质网增多，呈现出与正常上皮细胞相似的形态变化；MTT比色法测定结果显示不同浓度(2.5、5.0、7.5、10.0uM)SAHA对SMMC-7721细胞的增殖均有抑制作用，并有明显的剂量依赖和时间依赖关系；免疫细胞化学检测显示SAHA能显著降低PCNA和AFP在SMMC-7721细胞中的表达；流式细胞仪检测结果显示，SMMC-7721细胞经SAHA处理后，G0/G1期细胞明显增加，S期细胞则明显减少，细胞被阻滞于G0/G1期；RT-PCR检测结果表明，SAHA作用12h后SMMC-7721细胞中p21WAF1 mRNA的表达即有增加，24h后更为明显。

New antifungal agents have been developed over the past years based on the discovery of many new target sites of Candida albicands. For example, Echinocandins, aiming at the cell wall of Candida albicands, showed strong antifungal activities to fluconazole resistant candidas and fungal biofilm. Moreover, because β-glucan synthase does not exist on the cell membrane of mammalian cells, Echinocandins has a low toxicity and a promising clinical future. Though the mechanism of Histatin is not clear, it has strong activity not only on candida resistant of polyene and azole, but also to Candida parapsilosis, Candida krusei and Cry ptococcus neoformans. Berberine and Ocimum gratissimum L. were also found to have prominent anti-fungi activities.

近年来相继提出了许多抗白念珠菌药物作用的新靶点并成功开发出一些活性强大，疗效确切的抗真菌药，如以真菌细胞壁为靶点开发出棘白菌素类药物卡泊芬净、米卡芬净等，该类药物主要抑制β-葡聚糖合成酶，体外对氟康唑耐药的念珠菌属及真菌生物被膜表现出强大的抗菌活性，又由于β-葡聚糖合成酶在哺乳类动物细胞内不存在，故具有高效低毒的临床效果，是一极具前途的新型抗真菌药；以真菌细胞膜为靶点开发出Histatin类药物，虽然作用机制目前还不完全明了，但其作用不同于临床常用的多烯类和氮唑类，并已经发现Histatin5对两性霉素B和氮唑类耐药的念珠菌有效，并且对非白念珠菌如光滑念珠菌、克柔氏念株菌、隐球菌等也有杀灭作用；通过对植物药物的研究发现黄连素和丁香罗勒Ocimum gratissimum L。

In addition, it must also evade immune clearance. Elimination of H. pylori by phagocytes is inefficient because H. pylori exhibits several virulence factors to evade opsonization, retard phagocytosis, and disrupt membrane trafficking and phagosome maturation after internalization of the microorganism.

为了增加存活与持续的依附在宿主体内，幽门螺旋杆菌发展出一些策略来抵御被免疫清除的命运，它可影响吞噬细胞的功能，包括避免受调理作用、抑制吞噬细胞的吞噬作用、影响细胞内的运输作用与吞噬小体的成熟。

To determine the effectiveness of combining laser therapy with an immunosuppressive approach, the investigators recruited 14 subjects, aged 12 to 63 years, with Fitzpatrick skin types II to IV and having had vitiligo for a minimum of three months. A total of 43 vitiliginous lesions were randomized to receive either 308-nm excimer laser monotherapy twice weekly for six weeks or the laser sessions plus topical 0.1% tacrolimus ointment applied twice daily. Treated lesions were matched with untreated lesions on the subjects' opposite side.

为了确定结合雷射治疗与免疫抑制方式的效果，研究人员徵集14位受试者，年龄从12到63岁，患有Fitzpatrick皮肤类型II到VI的、而且有白斑至少3个月以上的患者；总共有43个白斑病灶被随机分派接受每周两次的308－nm准分子雷射治疗持续六周，或是雷射治疗加上0.1%局部tacrolimus软膏每天涂抹两次；治疗后的病灶再与受试者另外一边未接受治疗的病灶相比较。

Firstly, the acute cytotoxicity of profenofos on FG-9307 cells was studied, it was found that the cell growth rate was markedly reduced by profenofos at all the concentrations tested; and that the fine structures of the cells were also altered by profenofos, as evidenced by dilation of nuclear membranes and mitochondria cristae, and presence of enlarged lysosomes with engulfed organelles and numerous vacuoles in the cytoplasm.

丙溴磷对FG-9307的急性细胞毒性研究结果发现：1）在所有实验浓度下，细胞的生长速度均受到抑制。2）细胞的超微结构被丙溴磷所改变，最明显的特征则是线粒体损伤严重，嵴肿胀，部分溶解破裂；核膜肿胀，有溶解；细胞内的电子密度高的溶酶体增多；内质网的膜溶解，核糖体从粗面内质网上脱落下来，游离于胞质中。

Dawing fom the bitte lessonsof decades of often futile flood-fighting effots,these citiesae stifling the impulse to epai flood-damaged houses andae focusing instead on depopulating ivebanks,buying outpopeties in floodplains whee possible and moving peopleand businesses to highe gound.

这些城市从几十年徒劳无益的抗洪中吸取了惨痛的教训，抑制住修理被洪水毁坏的房子的冲动，集中精力疏散河岸的人口，可能的话，买断洪泛区的房地产，把居民和企业迁移剑较高的地段。

Almost all CF was released from Dansyl-PE by CTX-IX that osmosed the Dansyl-PE liposome like detergent; CF releases from PE or PS liposome induced by CTX-IX were related with both of CTX-IX and phospholipid concentrations, this indicated that the phase seperation should be a reasonable mechanism for CF permeability of PS or PE liposome in the presence of CTX-IX rather than CTX-IX channel formation on the membrane. CTX-IX influence of CF release of PC liposome was very slight. CF release from Dansyl-PE、PE or PE liposome in response to CTX-IX could be inhibited by Ca〓.

CTX-IX对靶脂如此种种强烈的作用，使得它引起含Dansyl-PE脂质体CF的泄漏犹如击污剂那样强烈；引起含PS或PE脂质体CF渗透的增加为一个与CTX-IX及磷脂浓度有关的二级反应过程，这种动力学特征提示渗透性增加的机制可能是CTX-IX在脂膜上产生的脂质分子相分离，而不是CTX-IX脂膜上形成通道；CTX-IX对PC脂质体渗透性几乎没有影响，而对上述脂质体渗透性增加作用均可被Ca〓所抑制。

But we don't care about Battlegrounds.

但我们并不在乎沙场中的显露。

Ah! don't mention it, the butcher's shop is a horror.

啊！不用提了。提到肉，真是糟透了。