被抑制的

It has been also demonstrated that lots of some chemical compounds not only have the utility of cancer therapy, but also can reduce the side effects of currently used drugs. Thus, to search for a succedaneum much more effective and easily absorbed by human-body seems to be an appropriate approach to substitute the presently used clinical remedy against cancer.

而在相关研究当中显示，许多抑制血管增生的化合物不仅有抑制肿瘤生长的作用且相对有著较低的副作用，因此寻找有效且容易被人体吸收的化合物用以取代目前临床对於癌症的治疗药物，似乎是比较妥当的方式。

The transforming growth factor-β superfamily, a large group of highly conserved growth factors including TGF-βs, activins and BMPs, regulate a wide variety of cellular functions such as proliferation, differentiation, apoptosis and migration. Signals from these growth factors are transduced by a group of Smad proteins. To date, there are nine vertebrate Smads, including the receptor-activated Smads , Smadsl-3, 5 and 8, the common mediator Smad4 and Smad4β, and the inhibitory Smads, Smad6 and 7. Signaling is initiated when the ligand induces assembly of a heteromeric complex of type Ⅱ and type Ⅰ TGFβ receptors. Then R-Smads are directly phosphorylated by activated type I TGF-β receptors.

在多种SMADS中，SMAD5令我们产生兴趣，基于三个原因：1、Smad5基因敲除胚胎中发现卵黄囊的异位造血以及CFU-GM祖细胞数目增加，表明SMAD5可能是早期造血发育的负向调控基因。；2、应用反义核酸封闭Smad5可以逆转TGF-β对祖细胞增殖的抑制效应，表明它可能介导TGF-β信号转导，后者的异常，包括某些SMADS的功能异常，和白血病紧密相关；3、Smad5基因定位在人染色体5q21，此区域的缺失和急性髓系白血病和骨髓增生异常综合症相关，因此，Smad5被怀疑为白血病抑制基因。

Sustained AF could be induced easily in all dogs during vagal nerve stimulation in vivo both before and after isolation of all PVs with encircling lesions created by a bipolar radiofrequency ablation clamp device. PV elimination had no effect on atrial effective refractory period or its responses to cholinergic stimulation. Autonomic ganglia were identified by bradycardic and/or tachycardic responses to high-frequency subthreshold local stimulation. Ablation of the autonomic ganglia overlying all PV ostia suppressed the effective refractory period-abbreviating and AF-promoting effects of cervical vagal stimulation, whereas ablation of only left- or right-sided PV ostial ganglia failed to suppress AF.

无论是在双极环状消融所有PV之前或之后，在体刺激颈迷走神经节过程中持续性房颤在所有犬均能轻易被诱导出，PV切除对心房肌的有效不应期或对胆碱的反应均没有影响，通过对高频的域下刺激发生快速或慢速反应来鉴定自主神经节，消融叠加于PV口部的自主神经节能抑制有效不应期的缩短、和刺激颈迷走神经诱发的房颤促进作用，而仅消融左或右侧PV口部的自主神经节却不能抑制房颤。

The importance of the control of proteolytic activity by inhibitors in physiological processes is demonstrated by the fact that inhibitor molecules exceed 10% of the total protein in human plasma.

生理学的程序的抑制剂的产生蛋白水解活动的控制的重要性被事实「抑制剂分子在人类的血浆中超过总计的蛋白质的 10%的」示范。

This study is design and preparation of active peptide analogues of mung bean trypsin inhibitor Lys fragment, Trichosanthes trypsin inhibitor I, carcinoembryonic antigen peptide and aspartame using solid and liquid phase peptide synthesis methods.

本论文研究活性多肽类似物的设计、制备和功能，分为四个部分，采用多肽固相和液相合成的方法，分别合成了活性多肽绿豆胰蛋白酶抑制剂 Lys片段长链16肽、天花粉胰蛋白酶抑制剂、癌胚抗原肽、甜味肽等一系列类似物，并测定了这些类似物的生物活性，有以下新的研究结果：1、furin酶抑制剂的设计、制备和功能；2、芳香氨基酸芳环之间的π-π共轭能部分补偿二硫键的作用；3、癌胚抗原肽Gly4被L-Pro替代可增加与HLA-A2分子的结合；4、肽键对甜味肽保持甜味是必须的。

Itamin D from the skin and diet is metabolized in the lier to 25-hydroxyitamin D (Figure 1), which is used to determine a patient's itamin D status1,2,3,4; 25-hydroxyitamin D is metabolized in the kidneys by the enzyme 25-hydroxyitamin D-1-hydroxylase (CYP27B1) to its actie form, 1,25-dihydroxyitamin D.1,2,3,4 The renal production of 1,25-dihydroxyitamin D is tightly regulated by plasma parathyroid hormone leels and serum calcium and phosphorus leels.1,2,3,4 Fibroblast growth factor 23, secreted from the bone, causes the sodium–phosphate cotransporter to be internalized by the cells of the kidney and small intestine and also suppresses 1,25-dihydroxyitamin D synthesis.5 The efficiency of the absorption of renal calcium and of intestinal calcium and phosphorus is increased in the presence of 1,25-dihydroxyitamin D (Figure 1).2,3,6 It also induces the expression of the enzyme 25-hydroxyitamin D-24-hydroxylase (CYP24), which catabolizes both 25-hydroxyitamin D and 1,25-dihydroxyitamin D into biologically inactie, water-soluble calcitroic acid.2,3,4

从皮肤和食物来的维生素D在肝中代谢为25-羟基维生素D（图1），被用来决定病人体内维生素D情况的1，2，3，4；25-羟基维生素D在肾中被25-羟基维生素D1羟化酶（CYP27B1）转变为有活性的1，25-二羟基维生素D 。1，2，3，4由肾产生1，25-二羟基维生素D是被血浆甲状旁腺激素和血清钙，磷水平紧密调节。1，2，3，4由骨分泌的成纤维细胞生长因子23使钠磷协同转运蛋白被肾和小肠细胞内化及抑制1，25-二羟维生素D合成。5 在1，25-二羟基维生素D作用下肾和小肠吸收钙及磷的效率增高(图1)。2，3，6 它也包括25-羟四- 24 -羟化酶的表达(CYP24)，且将1，25二羟基维生素D和25羟基维生素D异化成无生物活性，水溶性的维生素D3-23羧酸。2，3，4

Since H〓S and SO〓 adsorbed on TiO〓 could react with each other and TiO〓 is the medium of their electron transfer, thus SO〓 could not be adsorbed quite strong on the active site of TiO〓, which makes it more resistant to sulfating and increase the stability of catalyst. Finally, the model and mechanism of the reduction of SO〓 by NH〓 to elemental sulfur is advanced as follows: on the sulfide catalyst, ammonia is decomposed to N〓 and H〓, and H〓 reacts with SO〓 to form the intermedium of H〓S; then H〓S and SO〓 react as Claus reaction on TiO〓 catalyst.

反应系统中过量水蒸气的存在使催化剂表面某些活性位被水蒸气抑制使活性和选择性有较大幅度降低，但这种影响是可逆的，不会造成催化剂永久性中毒；另外当单质硫和水蒸气同时存在时，在〓催化剂上能够生成硫化氢和二氧化硫，而且由于硫化氢和二氧化硫化学吸附能力不同而导致它们的脱附顺序不同，硫化氢的生成温度总是低于二氧化硫的生成温度，说明过量水蒸气的存在会导致氧化物催化剂上逆克劳斯反应的发生；而在硫化物催化剂上几乎没有硫化氢和二氧化硫生成，说明硫化物催化剂能够抑制逆克劳斯反应的发生。

The first year's weeds on the Michigan plot are annual flowering plants , followed by tougher perennials like crabgrass and ragweed . Woodier shrubs will shade and suppress the flowers , followed by pines , which suppress the shrubs .

第一年到访的杂草是每年开花的草本植物，接着被更坚韧的多年生植物如沙果草和豚草取代，木本的灌木丛会荫蔽并抑制开花植物的生长，随后松树又抑制了灌木的生长。

Highly active, small-molecule furin inhibitors are attractive drug candidates to fend off bacterial exotoxins and viral infection. Based on the 22-residue, active Lys fragment of the mung bean trypsin inhibitor, a series of furin inhibitors were designed and synthesized, and their inhibitory activity toward furin and kexin was evaluated using enzyme kinetic analysis. The most potent inhibitor, containing 16 amino acid residues with a Ki value of 2.45×10~(-9) M for furin and of 5.60×10~(-7) M for kexin, was designed by three incremental approaches.

本论文研究活性多肽类似物的设计、制备和功能，分为四个部分，采用多肽固相和液相合成的方法，分别合成了活性多肽绿豆胰蛋白酶抑制剂Lys片段长链16肽、天花粉胰蛋白酶抑制剂、癌胚抗原肽、甜味肽等一系列类似物，并测定了这些类似物的生物活性，有以下新的研究结果：1、furin酶抑制剂的设计、制备和功能；2、芳香氨基酸芳环之间的π-π共轭能部分补偿二硫键的作用；3、癌胚抗原肽Gly4被L-Pro替代可增加与HLA-A2分子的结合；4、肽键对甜味肽保持甜味是必须的。

As a result, has "Yangxue, cooling blood, activating blood and" effect or inhibition of DNA synthesis, improvement of microcirculation function in food, are good for psoriasis, such as fruit drinks like Mume, grapefruit and so on with Qingre , blood-cooling, thirst-quenching Shengjin role, not only rich in vitamins and trace elements, can also lower blood lipids, blood viscosity, grapefruit and Huyou has been proven to inhibit the role of an effective split is effective psoriasis control summer fruit .

因此，凡有&养血、凉血、活血&之效或具有抑制细胞DNA合成，改善微循环功能的食物，对牛皮癣均有好处，如水果饮料之类的乌梅、柚子等都具有清热、凉血、解渴生津的作用，不仅含丰富的维生素及微量元素，还可以降低血脂、血粘度，西柚和胡柚已被证实具有抑制细胞的有效分裂的作用，是夏天防治牛皮癣有效水果。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。