被抑制的

Mmol/L. The activity of this catalase was not reduced by dithionite but was strongly inhibited by cyanide, azide, and 3-amino-1,2,4-triazole (the specific inhibitor of monofunctional catalase).

该过氧化氢酶不受连二亚硫酸钠的还原作用影响，但被氰化物、叠氮化物和3-氨基-1，2，4-三唑(单功能过氧化氢酶的专一抑制剂)强烈抑制。

Inhibition to biological treatment process by seven naphthalene derivatives was investigated with Rank Cell respirometer, and all the test chemicals were proved to be potential inhibitors to both activated sludge process and nitrification at different level.

用Rank Cell呼吸仪研究了2-萘酚、1-萘胺、5-氨基-1-萘酚、1-氨基-4-氯萘、2-萘磺酸、2-氨基-1-萘磺酸和7-氨基-4-羟基-2-萘磺酸等七种萘系列有机化合物对生物处理过程的抑制，证明被测化合物对活性污泥过程和硝化过程均有不同程度的抑制作用。

Based on the inhibition ability of extracts from seed capsule and endosperm,the seven seed sources were divided into 2 and 3 geographical groups,respectively.

依据种皮浸提液的抑制能力7个种源可分为2组，而依据胚乳浸提液的抑制能力则可被分为3组。

However, dexamethasooe did not seem to affect the sustained current and the sustained component of the biphasic current induced by ATP. The in hibitory effect of dexamethasonc on ATP induced currents was blocked by glucocorticoid receptor antagonist RU38486 (10μmol/L) and protein kinase A inhibitor H-89 (10μmol/L), but not by G protein inhibitor GDP-β-S (0.2mmol/L) and protein kinase C inhibitor chelerythrine chloride (10μmol/L).

地塞米松对ATP激活电流的快速抑制作用可被糖皮质激素受体拮抗剂RU38486(10μmol/L)、蛋白激酶A抑制剂H-89(10μmol/L)阻断，而G蛋白激活抑制剂GDP-β-S(0.2mmol/L)、蛋白激酶C抑制剂Chelerythrine chloride(10μmol/L)对地塞米松的快速抑制作用无明显影响。

Only when theenzyme was saturated by dCMP or allosteric activator dCTP, dAMPbehaved as a net isosteric competitive inhibitor.

只有当此酶被dCMP或别构激活剂dCTP饱和时，dAMP才表现出纯的同构竞争性抑制作用，其抑制常数为4×10~(-5)M，此值远低于T型和R型构象对dCMP的米氏常数。

When the activity of MAPK was sustained after electronic parthenogenetic activation, the activity of 〓 was also maintained.

放线菌酮不抑制GVBD的发生，但抑制MAPK的激活，此时〓也不被激活。

Results:①The amount of human colon carcinoma cell line SW480 treated by quercetin decreased. The morphology of partial SW480 cells was shrunk volume, integrated cell membrane, condensed cytoplasm, pyknotic chromatin, nuclear fragmentation. Apoptotic Corpuscles were found by electron microscope.②MTT colorimetric assay showed quercetin inhibited the growth of human colon carcinoma cell line SW480 in a time- and dose-dependent manner when the concentration of quercetin was 30、60、90μmol/L.③Flow cytometry analysis showed the cell cycle of SW480 cell was restricted in G1/S. G0/G1 phase rate increased and S phase rate decreased with increasing concentration of quercetin and time lasting.④ Zymogram analysis assay showed the secretion of matrix metalloproteinases in human colon carcinoma cell line SW480 treated by quercetin decreased. With increasing concentration of quercetin, the secretion of MMP-2 and MMP-9 decreased.⑤Immunohistochemistry method demonstrated the position expression of Cathepsin-D in SW480 cell was suppressed by quercetin in a time- and dose-dependent manner.

研究结果：经槲皮素处理的人结肠癌SW480细胞数量减少，部分细胞体积缩小，细胞膜完整，胞浆浓缩，核染色质固缩，细胞核碎裂，形成凋亡小体；MTT法检测显示当作用浓度为30μmol/L~90μmol/L时，槲皮素对人结肠癌SW480细胞的生长有抑制作用，其抑制作用随着作用浓度的增加和作用时间的延长而增强；流式细胞学发现槲皮素主要作用于人结肠癌SW480细胞周期的G1/S期，大部分细胞被阻断于S期，随药物浓度的升高和作用时间的延长，G0/G1期细胞比例逐渐增加，S期细胞比例逐渐减少；酶谱分析法检测显示不同浓度的槲皮素能够抑制人结肠癌SW480细胞分泌MMP-2及MMP-9，随浓度的升高，MMP-2及MMP-9的分泌量减少；免疫组织化学法显示不同浓度的槲皮素处理人结肠癌SW480细胞后，Cathepsin-D的表达随药物浓度的升高和作用时间的延长而降低。

The results showed that the three disparate treated substances have no visible antibacterial effect to E. coli , but a obvious effect to Staphylococcus aureus with inhibition of about 10 bacteriostasis units; have dissimilar effects to 10 kinds of fungi among the total kinds, and have a good inhibitory effect to Cytospora.coccodesHughes with fungistasis rate above 65%. After the gel filtration and activity detection, 50mM ammonium acetate was screened out as the more suitable eluents, the crudes were separated into strikingly unlike parts with obviously different antimicrobial activity.

结果表明，大蜡螟抗菌物质对大肠杆菌没有明显的抑制作用，而对金黄葡萄球菌抑制作用明显，抑菌活性单位在10左右；对10种植物病原真菌均有不同的抑菌活性，其中对苹果树皮腐烂病菌的抑制率达到65%以上；经过凝胶过滤分离，及对分离组分的抑菌活性测定，筛选出较合适的洗脱液为50mM乙酸铵，各分离组分抑菌活性差异明显，粗提物被分成了两个差异显著的部分。

Meanwhile,HDAC1 acetylation level is significantly increased.The overexpression of HDAC1 can promote erythroid cell proliferation and inhibits induced differentiation,the knockdown of HDAC1 or 2 inhibits erythroid cell proliferation and promotes induced differentiation.We also found that HDAC1 affects GATA1 mediated transcription activity.Thus our data revealed that HDAC1 may negatively regulate GATA1 mediated transcription and suggest that the dynamic regulation of GATA1 associated NuRD/MeCP1/HDAC1/HDAC2 complex may determine the onset of erythroid differentiation programs.Moreover,this study will eventually help to design new therapeutic approaches in treatment of leukemia.

研究发现在被诱导分化的小鼠红细胞白血病细胞中与GATA1相结合的HDAC1被乙酰化并失去活性，在血细胞中过表达HDAC1能够促进血细胞的增殖并抑制分化，反之在血细胞中敲除HDAC1或HDAC2能抑制血红细胞的增殖并促进分化，而且HDAC1能够负调控GATA1的转录活性，GATA1与NuRD/MeCP1复合体之间的动态调控，决定血红细胞分化的发生和发展，并为探索白血病的致病机理奠定了理论基础。

The results obtained are as follows.(1) Following microinjection of capsaicin (10μmol/L, 50nl) into the AP, MAP, HR and RSNA were significantly increased from l2.34±0.53 kPa,328.52±7.54 bpm and 100±0% to 15.17±0.25kPa (P.001), 354.81±8.54bpm (P.001) and 156.95±7.57%(P.001), respectively.(2) Ruthenium red (RR, 100mmol/L, 0.2ml, iv), a capsaicin receptor antagonist, significantly inhibited these effects of capsaicin.(3) Pretreatment with a NMDA receptor antagonist MK-801 (500μg/kg, 0.2ml, iv) also reduced these effects of capsaicin.

实验结果如下：(1)最后区内注射辣椒素可引起MAP、HR和RSNA明显增加，分别由12.34±0.53kPa、328.52±7.54bpm和100±0％增至15.17±0.25kPa（P＜0.001）、354.81±8.54bpm(P.001)和156.95±7.57%(P.001)；(2)静脉注射辣椒素受体阻断剂钌红(100mmol/L， 0.2ml)后，辣椒素的上述效应可被明显抑制；(3)预先应用NMDA受体阻断剂MK-801(500μg/kg， 0.2ml， iv)也明显抑制辣椒素的兴奋效应。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。