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The compound of the invention, which has never been discovered in Antrodia camphorate, can be applied in inhibiting the growth of cancer cells, such as breast cancer, hepatic cancer and prostate cancer; and be used as a pharmaceutical composition to inhibit the tumor growth; or further be applied in prevention of heart and blood vessel disease or dietary supplements for health needs through its antioxidant activity.

该化合物在此之前从来没有被发现,可以应用在抑制癌细胞的生长,如乳腺癌、肝癌和前列腺癌;和被用来作为药剂的组成,以抑制肿瘤的生长;或进一步通过其抗氧化活性应用在预防心脏和血管疾病或营养补充剂。

In clinical. acetylcholinesterase inhibitors reduce the breakdown of synaptic acetylcholine, have been modestly effective in improving the cognitive deficits of Alzheimer's disease.The goal of this work is to determine enzyme kinetics and mechanisms of acetylcholinesterase and butyrlcholinesterase inhibition by five cardiovascular drugs, lovastatin, simvastatin, amlodipine besylate, nifedipine, and hydralazine hydrochloride, and two benzodiazepines, diazepam and chlordiazepoxide hydrochloride. All drugs in this study are reversible mixed-type inhibitors of acetylcholinesterase and butyrylcholinesterase. The pKi values for acetylcholinesterase and butyrylcholinesterase inhibition by the cardiovascular drugs are linearly correlated with the molecular weights of the drugs with the slopes of 0.005 and 0.0021, respectively. Therefore, van der Waals' interactions between acetylcholinesterase and the cardiovascular drugs are stronger than those between butyrylcholinesterase and the drugs. This is probably due to a smaller active site gorge and a more significant peripheral anionic substrate binding site of acetylcholinesterase than those of butyrylcholinesterase.

本研究之目的系决定乙醯胆碱酯酵素和丁醯胆碱酯酵素被五种心脏血管药物lovastatin, simvastatin, amlodipine besylate, nifedipine、hydralazine hydrochloride和两种benzodiazepines:diazepam和Chlordiazepoxide hydrochloride的抑制作用之动力学及机转,这些药物都是乙醯胆碱酯酵素和丁醯胆碱酯酵素的可逆性、混合型之抑制剂,实验结果显示,五种心血管药物对於乙醯胆碱酯酵素及丁醯胆碱酯酵素抑制之pKi值和药物之分子量呈直线之关系,斜率分别为0.005及0.0021因此丁醯胆碱酯酵素,与心血管药物间之凡德瓦作用(van der Waals' )比乙醯胆碱酯酵素与心血管药物间者弱,这可能原因是丁醯胆碱酯酵素之活性区域比乙醯胆碱酯酵素之活性区域更宽广,但丁醯胆碱酯酵素之周边阴离子区域不及乙醯胆碱酯酵素之周边阴离子区域者明显重要,由於五种心血管药物对於乙醯胆碱酯酵素和丁醯胆碱酯酵素抑制之pKi值存在著线性关系表示此种抑制作用系经过共同之反应机理。

The effects on mouse's ileum can totally been inhibited by atropine, eserine, fugutoxin, and morphine.

对小鼠回肠的作用可完全被阿托品抑制,或被毒扁豆碱、河豚毒素或吗啡抑制。

ACE inhibitors, which are now widely used for the treatment of hypertension and heart failure, not only block the generation of Ang II from Ang I, but also prevent the degradation of bradykinin.

血管紧张素转换酶抑制剂现今被广泛应用于高血压和心脏病的治疗中,不仅可以抑制Ang I 到Ang II 的转化,同时还可抑制BK 的降解。

BmK IT2 associateed with and dissociated from its binding sites on insect synaptosomes quickly in two phase kinetic manner, and its specific binding was independence of membrane potential, but could be significantly inhibited by native BmK IT2, BmK AS and BmK AS-1 in a dose-dependent manner, and only partially by BmK Ⅰ or veratridine at high concentration.

BmK IT2能以两相动力学方式快速与昆虫突触体结合和解离,且其结合不依赖于膜电位,可分别被天然毒素BmK IT2,BmK AS和BmK AS-1剂量依赖地抑制,另也可被高浓度BmK Ⅰ和藜芦碱部分抑制。

Dipole source analysis found cingulate may be involved in executive inhibition processing.

这说明与低焦虑被试相比,高焦虑被试对正性图片采取了和负性图片相同的抑制策略,存在着过度抑制的倾向。

Usually, anti-apoptotic protein is insulated in organella, restraining the release of pro-apoptotic factor and controlling cell apoptosis. however, interacting with pro-apoptotic protein, it can not restrain apoptosis, induce the loss of mitochondrial function, accelerate the release of pro-apoptotic factor and result in apoptosis.

抑凋亡蛋白平时被隔离在线粒体等细胞器内抑制促凋亡因子的释放,具有抑制细胞凋亡的功能,但一旦与激活的促凋亡蛋白发生相互作用后,便丧失了对细胞凋亡的抑制作用,造成线粒体等细胞器的功能丧失和细胞器内促凋亡因子的释放,导致细胞凋亡。

Anti-apoptotic and pro-apoptotic factors have synergistic effect and play a switch role. Usually, anti-apoptotic protein is insulated in organella, restraining the release of pro-apoptotic factor and controlling cell apoptosis.

抑凋亡蛋白平时被隔离在线粒体等细胞器内抑制促凋亡因子的释放,具有抑制细胞凋亡的功能,但一旦与激活的促凋亡蛋白发生相互作用后,便丧失了对细胞凋亡的抑制作用,造成线粒体等细胞器的功能丧失和细胞器内促凋亡因子的释放,导致细胞凋亡。

The HE activity was almost completely inhibited by SBTI, p-APMSF, bestatin and NEM, greatly inhibited by ovomucoid, TLCK, IAM, chymostatin and PMSF, and slightly inhibited by pepstatin A, TPCK, LBTI and leupeptin. And these results imply that HE is most probably a trypsin-type serine protease.

抑制剂对其酶活性的影响结果显示,该孵化酶的活性几乎可被SBTI、p-APMSF、Bestatin和NEM所完全抑制,被ovomucoid、TLCK、IAM、chymostatin和PMSF所强烈抑制,而对pepstatin A、TPCK、LBTI和leupeptin不敏感,表明该酶极可能是一种属于胰蛋白酶类型的丝氨酸蛋白酶。

The agglutination for rabbit was the highest among erythrocytes of human, rabbit, common carp and crucian carp. The hemagglutinating activity for rabbit could not be inhibited by D-fructose, D-mannose, D-galactose, glucose, sucrose, manrmn, gamma-globulin and egg albumin, but inhibited by bovine-thyroglobulin, and the minimum inhibitory concentration was 3.10 mg/ml.

该凝集素可以凝集人的A、B、AB、O型红细胞,且凝集活性相同,在对人、兔、鲤、鲫的红细胞的凝集作用中,对兔红细胞的凝集作用最强,且不被己测试的D-半乳糖、D-果糖、D-甘露糖、葡萄糖、蔗糖、甘露聚糖、γ-球蛋白、卵清蛋白所抑制,仅被牛甲状腺球蛋白抑制,最小抑制质量浪度为3.10mg/ml。

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On the other hand, the more important thing is because the urban housing is a kind of heterogeneity products.

另一方面,更重要的是由于城市住房是一种异质性产品。

Climate histogram is the fall that collects place measure calm value, cent serves as cross axle for a few equal interval, the area that the frequency that the value appears according to place is accumulated and becomes will be determined inside each interval, discharge the graph that rise with post, also be called histogram.

气候直方图是将所收集的降水量测定值,分为几个相等的区间作为横轴,并将各区间内所测定值依所出现的次数累积而成的面积,用柱子排起来的图形,也叫做柱状图。

You rap, you know we are not so good at rapping, huh?

你唱吧,你也知道我们并不那么擅长说唱,对吧?