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The transforming growth factor-β superfamily, a large group of highly conserved growth factors including TGF-βs, activins and BMPs, regulate a wide variety of cellular functions such as proliferation, differentiation, apoptosis and migration. Signals from these growth factors are transduced by a group of Smad proteins. To date, there are nine vertebrate Smads, including the receptor-activated Smads , Smadsl-3, 5 and 8, the common mediator Smad4 and Smad4β, and the inhibitory Smads, Smad6 and 7. Signaling is initiated when the ligand induces assembly of a heteromeric complex of type Ⅱ and type Ⅰ TGFβ receptors. Then R-Smads are directly phosphorylated by activated type I TGF-β receptors.

在多种SMADS中,SMAD5令我们产生兴趣,基于三个原因:1、Smad5基因敲除胚胎中发现卵黄囊的异位造血以及CFU-GM祖细胞数目增加,表明SMAD5可能是早期造血发育的负向调控基因。;2、应用反义核酸封闭Smad5可以逆转TGF-β对祖细胞增殖的抑制效应,表明它可能介导TGF-β信号转导,后者的异常,包括某些SMADS的功能异常,和白血病紧密相关;3、Smad5基因定位在人染色体5q21,此区域的缺失和急性髓系白血病和骨髓增生异常综合症相关,因此,Smad5被怀疑为白血病抑制基因。

In some circumstances the red phase transition accompanies strong fluorescence. The unique chromatic properties of molecular recognition made PDA vesicles a promising biosensor and many biological species, such as virus, bacteria, lipolytic enzyme, antimicrobial peptide,mammalian peptide, ions, antibody-antigen and oligonucleotide etc.

这种囊泡将检测与显示集为一体,是一种典型的生物分子器件,近年来已被用于很多物质的测定,其中包括病毒、细菌、亲脂性酶、抗菌肽类、哺乳动物肽类、离子、抗体、蛋白质和寡核苷酸等。

As this infarct in the brain is organizing and being resolved, the liquefactive necrosis leads to resolution with cystic spaces.

脑组织梗死灶正在进行机化并且逐渐被溶解液体吸收后往往形成囊腔。

CT images of the 6 UAs showed homogenous and low density in comparison with muscles. Of the 6 UAs, 2 (33%) were lobulate, 4 (67%) were regularly round or oval; 1 (17%) had bone septa, 2 (33%) had root resorption of the neighboring teeth, 3 (50%) had cortical perforation. All UAs showed well-circumscribed margins without soft tissue masses. Three UAs were examined by enhanced studies and showed mild to moderate enhancement of the wall. Of the 5 MAs, 3 (60%) showed low to intermediate density as compared with muscles, 2 (40%) showed homogenous and intermediate density; 3 (60%) had bone septa; 3 (60%) showed root resorption or destruction of the neighboring teeth. All 5 MAs were lobulate with cortical perforation, soft tissue masses, and ill-defined margins. All 3 MA5 examined by enhanced studies showed strong enhancement. CONCLUSIONS: SMAs are usually seen in middle-aged patients.

UA病变平扫时与肌肉相比内部都呈均匀低密度,其中4例(67%)呈较规整的圆形或椭圆形,2例(33%)呈分叶状,3例(50%)局部骨皮质有缺损,但未见软组织肿块形成,l例(17%)见不全骨性分隔,2例(33%)邻近牙根有吸收,行增强扫描的3例囊壁均呈轻中度的强化。5例MA的病灶都呈分叶状,且骨皮质均被穿破并有软组织肿块形成,边界不清,其中3例(60%)平扫时与肌肉相比呈等低混杂密度,2例(40%)呈较均匀等密度,3例(60%)可见不全的骨性分隔,3例(60%)见牙根的吸收或破坏,行增强扫描的3例都呈明显强化。

As well, Mandelic acid has been shown to benefit individuals with cystic acne.

以及,扁桃酸已被证明有利於个人与囊性痤疮。

As well, Mandelic acid has been shown to benefit individuals with cystic acne.

以及,扁桃酸已被证明有利于个人与囊性痤疮。

The melanotic encapsulation of oocysts is a specific immune defence mechanism against Plasmodium infection ,and is also a primary phenotype in the Plasmodium-refractory strain of An.gambiae.

卵囊黑化包被反应是按蚊抵御疟原虫感染的特异性免疫防御机制,也是抗性株冈比亚按蚊或不易感按蚊的最主要表型。

Prophenoloxidase is a key enzyme for mediating melanotic encapsulation of oocysts,which may be transformed into active phenoloxidase by limiting proteolysis.

而前酚氧化酶(Prophenoloxidase,PPO)是介导卵囊黑化包被反应的一种关键酶,活化后可催化酪氨酸羟基化为二羟基苯基丙氨酸,二羟基苯基丙氨酸和多巴胺可进一步氧化为具有活性的苯醌活性,苯醌即可介导蛋白交联并聚合成黑色素层固定、隔离或杀死入侵的病原体。

The optimum work concentration of the indirect ELISA for detecting and screening positive hybridoma cells was established by research again and again. Polystyrene microtitration plates were coated with the purified DHV antigen at the amount of 0.5μg/well.

对鸡胚和鸭胚增殖的尿囊液病毒用反复冻融、氯仿处理、0.22μm滤膜过滤、PEG反透析浓缩以及Sephadex G-200分子筛层析的方法进行纯化,并以此来包被酶标板以及进行BALB/c小鼠免疫,效果良好。

Preoperative recognition of multilocular cystic renal cell carcinoma is possible using strict computerized tomography criteria.

多数肿瘤术前可以确诊,但间隔过少、过薄、强化不显著者可能被误诊为多房囊性肾瘤或肾囊肿。

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We have no common name for a mime of Sophron or Xenarchus and a Socratic Conversation; and we should still be without one even if the imitation in the two instances were in trimeters or elegiacs or some other kind of verse--though it is the way with people to tack on 'poet' to the name of a metre, and talk of elegiac-poets and epic-poets, thinking that they call them poets not by reason of the imitative nature of their work, but indiscriminately by reason of the metre they write in.

索夫农 、森那库斯和苏格拉底式的对话采用的模仿没有一个公共的名称;三音步诗、挽歌体或其他类型的诗的模仿也没有——人们把&诗人&这一名词和格律名称结合到一起,称之为挽歌体诗人或者史诗诗人,他们被称为诗人,似乎只是因为遵守格律写作,而非他们作品的模仿本质。

The relationship between communicative competence and grammar teaching should be that of the ends and the means.

交际能力和语法的关系应该是目标与途径的关系。

This is not paper type of business,it's people business,with such huge money involved.

这不是纸上谈兵式的交易,这是人与人的业务,而且涉及金额巨大。