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A major UPR protective response is the induction of the ER chaperone GRP78/BiP, which is expressed at high levels in a variety of tumors and confers drug resistance in both proliferating and dormant cancer cells.

该模型的小鼠Grp78的表达水平是正常的一半,模拟了抗Grp78药对Grp78表达的部分抑制作用。

Western-blot and immunohistochemical assay methods were employed to detect the expression of FHIT. Apoptosis and cell cycle of cell were analyzed by FCMS. Morphological changes were observed by compound and electron microscope.

然后用流式细胞仪,普通光镜及透射电镜对获得稳定FHIT蛋白表达的转染组细胞和空真核表达质粒转染组细胞及未转染的亲本细胞凋亡的状况进行了考察,另外还通过流式细胞仪检测了三组浙江大学硕士学位论文细胞生长周期的惰况。

A person who does not deliberately dispose of all his thoughts alike in cumbrous draperies and flimsy disguises may strike out twenty varieties of familiar everyday language, each coming somewhat nearer to the feeling he wants to convey, and at last not hit upon that particular and only one which may be said to be identical with the exact impression in his mind.

一个人写文章,只要他不是立志要把自己的真意用重重锦绣帐幔、层层多余伪装完全遮掩起来,他总会从熟悉的日常用语中想出一二种说法,一个比一个接近他所要表达的情感,只怕到了最后,他竟会打不定主意要用哪一种说法才能恰如其分地表达自己的心意哩!

However, little isknown about whether Candesartan can stabilize and reduce plaque disrupture bydecreasing the macrophage accumulation and reducing MMP-9 expression in the plaque,moreover, it is not clear about the effect of Telmisartan on AT1/AT2 receptor and MMP-9expression of monocyte-macrophages.

但ARB类药物坎地沙坦是否通过减少斑块内巨噬细胞聚集、降低MMP-9的表达从而稳定斑块并具有预防斑块破裂的作用,以及替米沙坦对单核/巨噬细胞AT1、AT2受体、MMP-9表达的作用如何,目前相关的实验研究较少。

Methods RPE cells were exposed to shear stress of 2 dyne/cm2 for 0, 0.25, 0.5, 0.75, 1, 1.5, and 3 h. Reverse transcription polymerase chain reaction was used to detect the levels of c-fos and c-myc mRNA in RPE cells. One-way analysis of variance was used to compare the differences.

用2 dyne/cm2的剪切力作用于体外培养的人RPE细胞,作用时间分别为0、0.25 h、0.5 h、0.75 h、1 h、1.5 h和3 h,采用逆转录聚合酶链反应观察c-fos和c-myc mRNA的表达变化,并采用单因素方差分析比较各时间点之间表达的差异。

The predominant expression in the gill, hepatic caecum, hind-gut, endostyle, and ovary may be in line with a rapid energy turnover in these tissues.

广泛表达的模式说明它可能行驶基本的生理功能,肝盲囊、后肠、卵巢和内柱的高量表达与这些组织的快速能量代谢有关。

Objective To construct an eukaryotic gene expression vector for CD44v6 and its expression in tumor cells.

目的构建含人的肿瘤侵袭和转移的特异性抗原CD44v6编码基因的真核表达的重组载体,进行核苷酸序列分析,并在肿瘤细胞中表达。

Theoretically, re-expression of tumor suppressor genes by demethylating agents may contribute to inhibiting the development of tumor. It has been suggested that DNA hypermethylation results in resistance to chemotherapy and consequently reduces the efficacy of chemotherapeutic treatment.

由于高度甲基化而暂停表达的抑癌基因,如果能应用去甲基化制剂逆转甲基化的异常状态,使之重获表达,理论上即可发挥其抑制肿瘤细胞生长的功能。

They also recall Kandinsky's interest in art and spirituality and his efforts to find visual form for the ineffable energies and harmony of the universe.

这些作品也让人想起康丁斯基对艺术与灵性的兴趣,以及他努力发掘视觉形式以表达宇宙的无法表达的能量和和谐。

They also recall Kandinsky's interest in art and spirituality and his efforts to find visual form for the ineffable energies and harmony of the universe.

这些作品让人想起康丁斯基对艺术与灵性的兴趣,以及他努力发掘视觉形式以表达宇宙的无法表达的能量和和谐。

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The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应,而且减少跟风的可能性。

The new PS20 solar power tower collected sunlight through mirrors known as "heliostats" to produce steam that is converted into electricity by a turbine in Sanlucar la Mayor, Spain, Wednesday.

聚光:照片上是建在西班牙桑路卡拉马尤城的一座新型PS20塔式太阳能电站。被称为&日光反射装置&的镜子将太阳光反射到主塔,然后用聚集的热量产生蒸汽进而通过涡轮机转化为电力