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The present study demonstrated the gingival overgrowth is characterized by specific miRNAs expression profile. In the preliminary study, we established a databank by using microarray analysis of miRNAs and gene expression from one patient with inherited gingival fibromatosis.

首先,在初步实验中利用遗传性牙龈纤维瘤病患者的牙龈组织进行了微型核醣核酸以及基因表现的微阵列分析,建立了庞大的资料库,并且证明在增生的牙龈组织中,某些特定的微型核醣核酸及基因有特异的表现;因此,我们加入另外两位患有牙龈增生的组织检体来分析,共同进行数据的比对,减少个体表现差异的干扰;结果显示:共有六种微型核醣核酸在牙龈增生的实验组中具有一致的表现趋势,包括miR-203,-143,-145,-200a,-200b,-923。

The changes of information environment are mainly reflected in the arrival of ubiquitous information environment. The changes of information systems are mainly reflected in the impact of new interest pattern and systems. The changes of business models are reflected in the rapid development of international, cooperative and virtual business. The changes of resource types are inflected in the increasing of free resources, as well as the integration of resources and services.

信息环境的改变主要表现在泛在信息环境的到来,制度内容的改变主要表现在新的利益格局和制度体系的变化,业务模式的改变主要表现在国际、协作与虚拟业务的迅速发展,资源类型的改变主要表现在免费资源的增长、资源和服务的集成。

X displays right pulmonary tuberculosis accounted for 30.4% the left lung accounted for 18.8% the double lung accounted for 50.8% between the lung nature venereal diseases changes the performance is two lung textures increases thickly the edge is fuzzy the lung hilus increases the disorganization accounted for 62.3%; The lobulous lung essence infiltration pathological change performance is in two lungs retires the inner tube spot laminated shape and the cloud cotton wool shape shadow the focus of infection fusion may assume the ground glass density to account for 30.5%; The lung section substantive infiltration pathological change displays for the boundary clear triangle or the fan-shaped big laminated high density was 7.2%.

胸部X线表现右肺病变者占30.4%,左肺占18.8%,双肺占50.8%,肺间质性病变表现为两肺纹理增粗,边缘模糊,肺门增大,结构紊乱占62.3%;小叶性肺实质浸润病变表现为两肺中、下野内带斑片状及云絮状阴影,病灶融合可呈磨玻璃密度占30.5%;肺段实质性浸润病变表现为边界清楚的三角形或扇形大片状高密度阴影占7.2%。

X displays right pulmonary tuberculosis accounted for 30.4% the left lung accounted for 18.8% the double lung accounted for 50.8% between the lung nature venereal diseases changes the performance is two lung textures increases thickly the edge is fuzzy the lung hilus increases the disorganization accounted for 62.3%; The lobulous lung essence infiltration pathological change performance is in two lungs retires the inner tube spot laminated shape and the cloud cotton wool shape shadow the focus of infection fusion may assume the ground glass density to account for 30.5%; The lung section substantive infiltration pathological change displays for the boundary clear triangle or the fan-shaped big laminated high density was 7.2%.

结果 7个月~1岁发病例数占4.3%;1~3岁占17.4%;4~7岁占46.4%;8~13岁占31.9%。咳嗽占100%;发热占63.8%;56.5%无肺部体征。胸部X线表现右肺病变者占30.4%,左肺占18.8%,双肺占50.8%,肺间质性病变表现为两肺纹理增粗,边缘模糊,肺门增大,结构紊乱占62.3%;小叶性肺实质浸润病变表现为两肺中、下野内带斑片状及云絮状阴影,病灶融合可呈磨玻璃密度占30.5%;肺段实质性浸润病变表现为边界清楚的三角形或扇形大片状高密度阴影占7.2%。

Results Of a total of 100 cases, 51(51%) were confirmed as linear scleroderma, 26 (26%) as plaque morphea, 26 (26%) as deep morphea, 12(12%) as generalized morphea, and 15(15%) as a mixed subtype. Nine patients (9%) had family histories of rheumatic or autoimmune diseases, while 16(16%) might be triggered by unknown factors. Totally 84 patients underwent antinuclear antibody tests and 38 patients (45.2%) had positive results.

结果 100例患者中,51例(51%)出现线状硬皮病表现,26例(26%)出现斑块状硬斑病表现,26例(26%)出现深在性硬斑病表现,12例(12%)出现泛发性硬斑病表现,其中15例(15%)为两型混合;9例(9%)患者有风湿性或免疫性疾病家族史,16例(16%)患者可能与某种诱发因素有关。84例行抗核抗体检测的患者中,有38例(45.2%)为阳性。

Cases displayed simple slice infiltrative focus:③ Six eases with fungal pneumonia: 4 cases were pulmonary aspergillosis, in which 2 cases displayed multiple-slice shadow with cavity formation and 1 ease displayed multiple-tubercle shadow and 1 ease displayed single conglomerate shadow. 2 eases of pulmonary mucormycosis displayed diffuse spot slice and small slice shadow with partial fusion.

真菌性肺炎6例:4例为肺曲霉菌病,2例表现为两肺多发片状影伴空洞形成、1例表现为多发小结节影、1例表现为单发团块状影;2例肺毛霉菌病表现为两肺弥漫性斑片状、小片状影,部分融合。

Results: Most synovial sarcomas located in the extremities close to joints. Synovial sarcomas detected by radiography typically appeared as round, oval or multilobulated juxtaarticular soft-tissue masses with calcification in some cases. The most common CT appearance of synovial sarcoma was heterogeneous deep -seated soft-tissue mass with attenuation similar to or slightly lower than that of muscle. On T1WI, synovial sarcomas typically appeared as prominently heterogeneous multilobulated soft tissue masses with signal intensity similar to or slightly higher than that of muscle. On T2WI, synovial sarcomas appeared as prominent heterogeneity with predominantly high signal intensity.

结果:大部分滑膜肉瘤位于关节旁;X线表现为圆形、椭圆形或分叶状软组织肿块,部分可见肿块内钙化;典型的CT表现为较深在的、等或稍低密度不均匀的软组织肿块;磁共振T1WI与肌肉信号相比,滑膜肉瘤表现为分叶状、不均匀、等或稍高信号,T2WI则表现为高信号为主的不均匀信号;DSA呈显著的肿瘤实体染色及新生血管。

After the selection from one to three generations, several mutants were obtained. The major mutants included non-nodule mutants (18 lines) which failed to nodulate after inoculated with rhizobia for two weeks, ineffective nodulation mutants (9 lines) which had less uneven and white or transparent nodules, an abnormal leaf and flower mutant which was dwarf without stipules, abnormal flowers and less nodules, and a slender mutant with a thin stem and smaller leaves.

从种植的三代植株中,筛选到多种共生固氮根瘤的突变体,其中不结根瘤突变体18个株系,表现为接种根瘤菌两周后无根瘤形成;结无效根瘤突变体9个株系,表现为根瘤数目少且分布不均匀,根瘤呈白色,有些为半透明;花叶形态异常突变体1个株系,表现为除根瘤数目少外,植株矮小、托叶消失、花形态异常;纤细突变体1个株系,表现为除根瘤数目少外,植株变小、茎细叶小。

The appearances of nonvascular lesions were as the following : solitary, huge cystic lesions with wall and septa obvious enhancement were found in malignant enbryonal sarcoma; mixed density mass with necrotic cystic change and solid portion enhanced obviously in carcinosarcoma; intrahepatic huge low density, cystic changes, calcification and margin enhancement were found in leiomyosarcoma.

血管源性表现为肝内多发低密度灶,强化明显,非血管源性表现为肝内巨大单发囊性病灶,增强囊壁和分隔明显强化;癌肉瘤表现为混杂密度肿块伴有坏死囊变,增强实质部分强化;平滑肌肉瘤表现为肝内巨大低密度病灶,可伴有囊变及钙化,增强见边缘强化。

The results indicated that the typical apoptosis was induced by PRRSV in lungs and uteri. The ultrastructural changes showed different characterizations at different stages of the infection. During the early stage from 8th h to day 3 postinfection,the apoptosis cells shrank,the cytoplasm concentrated,the chromatin condensed,the kernel disaggregated and the endoplasmic reticulum dilated. During the middle stage from day 5 to day 9 postinfection,the apoptosis cells evidently shrank,the cell membranes protu berated,the plastosome manifolded,and apoptosis bodies were found. During the last stage from day 10 upwards postinfection,the apoptosis bodies degenerated and disappeared,and no inflammation occurred. Few apoptosis cells were necrotic.

结果表明,PRRSV可诱导宿主肺和子宫发生典型的细胞凋亡,表现为细胞的超微形态结构随着病毒感染进程出现不同的特征性变化,早期(感染后第8 h至第3 d)凋亡细胞多表现为细胞体积缩小,细胞质密度增强,染色质浓缩,核仁解体,内质网扩张;中期(感染后第5 d至第9 d)凋亡细胞体积显著缩小,细胞膜突起,线粒体增多,有凋亡小体形成;晚期(感染后第10 d以后)凋亡细胞形态多表现为凋亡小体降解和消失,少数凋亡细胞在凋亡晚期表现为坏死细胞。

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