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Restoration of ODC expression in the HL60-ODC cells resulted in rescue of rottlerin-induced apoptosis of HL60 cells. Simultaneously, phosphothreonine-ODC of rottlerin-treated HL60-ODC cells was highly elevated comparing with HL60-pcDNA3 cells. Taken together, we suggested that rottlerin, a PKCd inhibitor, might decrease phosphothreonine-ODC to reduce both protein stability and enzyme activity of ornithine decarbooxylase and finally resulted in cell apoptosis.

为了侦测鸟胺酸去羧化是否能够负调节rottlerin所引发的细胞凋亡,我们将具有鸟胺酸去羧化cDNA载体稳定转染至HL60细胞内,此细胞称为HL60-ODC细胞,另转染载体的细胞称为HL60-pcDNA3细胞;实验发现HL60-ODC细胞中的鸟胺酸去羧化蛋白为HL60-pcDNA3细胞与HL60细胞表现之2.5倍,同时HL60-ODC细胞提升鸟胺酸去羧化蛋白表现,能够减少rottlerin造成之细胞凋亡现象,并且此蛋白在HL60-ODC细胞中酥胺酸磷酸化较HL60-pcDNA3细胞表现高。

The patients with lower serum glycine or D-serine levels, more severe negative symptoms and cognitive deficits, abnormal expression in mRNA or protein levels of certain genes (e.g., lower expressions of SHMT2, PSAT1 and serine racemase; higher expressions of AMT and ASCT1) may be more likely to respond to sarcosine.

此外,用药前具有较低的血清glycine或D-serine浓度、较明显的负性症状或认知功能缺损、以及特定基因於mRNA或蛋白质层次表现异常(如:SHMT2、PSAT1及serine racemase表现较低,而AMT及ASCT1表现较高)的患者,可能对sarcosine有较佳的治疗反应。

Results In 11 cases,5 cases were intracranial,and 6 cases intravertebral canal.MRI could effectively show similarly shuttle or long-round shape's abnormal signal imaging.The T1W imaging showed uniformity or asymmetric and low or equal signal.The borders were slighty low or equal signal intensity,some had spetum.The T2W imaging showed obviously high signal,and a few cases showed slightly high or equal signal,while the borders showed slightly low or equal signal imaging.The thin peripheral could be obviously enhanced,but without inner enhancement.

结果 11例中发生于颅内5例,椎管内6例,其 MRI 表现:断面上显示为在颅板下或椎管内的梭形或长圆形异常信号影, T1WI 上表现为均匀或不均匀的低、略低或等信号影,周边为略低或等信号的较厚边缘,少部分(2例)有分隔; T2WI 上多表现为较明显的高信号,少数呈等、略高信号,并可见略低或等信号的边缘;增强扫描病灶边缘明显强化,其内无明显强化或不强化,1例病灶呈较均匀的强化,1例病灶部分呈片状强化。

A generation after that, Immanuel Kant argued that human beings could never know reality as it is in itself but only their own mental representations, but, since these representations had a common source, each person's experiences were coordinated with the mental representations of all the others to produce what he called the phenomenal world.7 In the early Twentieth Century, the founder of phenomenology, Edmund Husserl, was more solipsistic.

有一个时代过去,康德争辩说一个人永远无法靠自我的精神表现知道真实,但是,这些表现都有一个共同的源头,每个人的经验都和其他人产生的精神表现同等,我们叫那知觉世界。7 在12世纪早期,现象学的创始人,埃德蒙特·胡塞尔,更为自我中心。

Possible factors of affecting on learning addition and substraction computation were impression of mathematics and the learning motivation in personal aspect, teaching ways and learning the concepts of addition and subtraction in school aspect, single parent families, grandparents' teaching, resources of the community, parents' expectation and disciplinary attitude, parents' level of education and status of social economy in living aspect.

学童对数学的学习兴趣与动机乃是影响学童学习表现的个人心理因素,而教师的教学方式、学童学习概念的成果则是学习资源影响学童学习表现的因素,再者,族群天性、单亲家庭及隔代教养问题、社区资源、家长对学童的期望与管教、家长的教育程度与社经地位等,都是生活环境影响学童学习表现的因素。

In subliminal affective priming task, there were no significant differences of correct rates and latencies between alexithymic and nonalexithymic,while on the both two SOA levels (200ms and 300ms) of supraliminal priming task, the mean response latencies of alexithymic were longer than those of nonalexithymic.(4) In both subliminal and supraliminal affective priming tasks, P2 and P3 were elicited by both alexithymic and nonalexithymic during performing the affective priming task.

情绪启动效应早期的ERPs特征表现为启动条件和非启动条件的P2潜伏期均显著短于控制条件的P2潜伏期,而P2波幅则显著大于控制条件的P2波幅,这种效应在顶区表现得尤其明显;情绪启动效应晚期的ERPs特征表现为启动条件P3潜伏期显著短于非启动条件的P3潜伏期,而P3波幅显著小于非启动条件和控制条件的P3波幅,这种差异也主要见于顶区。

Results Of 60 cases,55 cases were unilateral,5 cases was bilateral.25 cases of cerebral flax subdural hematomas presented as strip-shaped,10cases presented as little-belt shaped,4 bilateral cases through MRI presented as U-shaped,7 cases of cerebellar tentorium hematomas presented as flakes,5 cases presented as fan-shaped.

结果 60例中发生于单侧55例,双侧5例;大脑镰硬膜下血肿25例表现为条索状,10例呈小带状,发生于两侧4例,MRI表现为双轨征,小脑幕下血肿7例呈片状,5例呈扇形,MRI表现为片带状高信号影,小脑幕并大脑镰硬膜下血肿6例呈&Y&形,3例呈镰刀状。

Results Of 60 cases,55 cases were unilateral,5 cases was bilateral.25 cases of cerebral flax subdural hematomas presented as strip-shaped,10cases presented as little-belt shaped,4 bilateral cases through MRI presented as U-shaped,7 cases of cerebellar tentorium hematomas presented as flakes,5 cases presented as fan-shaped.

结果 60例中发生于单侧55例,双侧5例;大脑镰硬膜下血肿25例表现条索状,10例呈小带状,发生于两侧4例,MRI表现为双轨征,小脑幕下血肿7例呈片状,5例呈扇形,MRI表现为片带状高信号影,小脑幕并大脑镰硬膜下血肿6例呈&Y&形,3例呈镰刀状。

Whangkeumbae and Yali Pear were used in the determination of nutritional components contents during fruits maturation: contents of soluble sugar, fructose, glucose and sucrose gradually increased, contents of starch, vitamin C and cellulose gradually decreased, contents of protein and titrable acid increased first and then decreased, content of major elements decreased and content of minor elements showed different trends.

黄金和鸭梨两个品种表现出相同的变化规律,其中:可溶性糖、果糖、葡萄糖、蔗糖含量在果实成熟过程中均呈上升趋势;淀粉、维生素C和纤维素含量呈下降趋势;可溶性蛋白和可滴定酸含量呈先上升后下降的变化趋势;矿质元素中大量元素均表现出下降趋势而微量元素则表现不同的变化趋势。

Two kinds of silicon samples with distinct surface treatment, i. e., one surface was chemically etched and the other was unetched, were used to investigate the characteristics of leakage current and surface flashover of semiconductor under impulse voltage in vacuum. The experimental results showed that the surface conditions of samples affected these characteristics greatly. Before flashover, the Ohmic current was observed for unetched samples and the space charge limited current for etched samples, respectively. Meanwhile both samples showed quite different flashover tracks, and the surface-etched samples displayed a much higher onset voltage of flashover.

对采用和未采用表面化学腐蚀处理的半导体硅在冲击电压下的实验表明(参见 Zhang et al , Applied Physics Letters, 2002),试品的表面状况对其泄漏电流和沿面闪络特性有着很大的影响:在沿面闪络之前,未经处理试品的泄漏电流表现为 Ohm 性电流,而表面处理过的试品表现为空间电荷限制电流特性;同时两类试品表面的闪络通道也表现出不同的特征,而采用表面化学腐蚀处理可以明显提高其沿面闪络电压。

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However, as the name(read-only memory)implies, CD disks cannot be written onorchanged in any way.

然而,正如其名字所指出的那样,CD盘不能写,也不能用任何方式改变其内容。

Galvanizes steel pallet is mainly export which suits standard packing of European Union, the North America. galvanizes steel pallet is suitable to heavy rack. Pallet surface can design plate type, corrugated and the gap form, satisfies the different requirements.

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A single payment file can be uploaded from an ERP system to effect all pan-China RMB payments and overseas payments in all currencies.

付款指令文件可从您的 ERP 系统上传到我们的电子银行系统来只是国内及对海外各种币种付款。