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This thesis studies the volcanic tectono-petrofacies, petrology, mineralogy, geochemistry, isotopic chronology, stratum and high-precision SHRIMP zircon U-Pb datings of the Mt.Yandangshan volcano-intrusive complex, and concludes that: Yandangshan volcanic rock units belong to high-K calc-alkaline acid rock associations, mainly ryholitic and trachytic dacitic in composition. They have A/CNK values of 0.9-1.2 (i.e., aluminium saturation and supersaturation), enriched LREE and LILEs and depleted HFSE. Their 8Eu values are 0.11-0.32, indicating a evident fractional evolution of plagioclase crystallization. Their ∑REE varied very limitedly,(87~Sr/(86)Sri ratios and eNd values are 0.7086～0.7095 and -10.20～-9.96 for volcanic rocks, and 0.7087~0.7095 and -7.6～6.92 for the central intrusive facies syenite, which means that all the igneous rocks from Mt. Yandangshan are evolutional products of magmas with the same source, and that they derived mainly from crust, but mixed with mantle components.

本文从火山构造岩相学、岩石学、矿物学、地球化学、同位素年代学、地层学等方面出发，同时结合高精度SHRIMP锆石U-Pb定年，对雁荡山火山岩进行了系统的研究，确定雁荡山火山岩为一套以流纹质和粗面英安质为主体的高钾钙碱性酸性岩石组合，A/CNK值集中在0.9～1.2之间，为铝饱和或铝过饱和类型；富轻稀土元素和大阳离子亲石元素、相对亏损高场强元素：负铕异常明显，δEu值为0.11～0.32，表明岩浆经历了以斜长石为主的强烈结晶分异作用：岩石样品的∑REE变化有限，火山岩样品的~(87Sr/~(86)Sr_i为0.7086～0.7095，εNd为-10.20～-9.96，中央侵入体石英正长岩~(87Sr/~(86)Sr_i为0.7087～0.7095，εNd为-7.6～-6.92，表明它们是同源岩浆分异演化的产物，物质来源主要为陆壳，但有地幔物质参与。

The RT-PCR product was inserted into pTG19-T vector and transformed into E. coli successfully. By blastn, the sequence results of Kunming mus musculus were in complete accordance with the conservative sequence of Genbank NR_003278 (791bp-1153bp). By Blastn in NCBI, the sequence with little difference among animals was confirmed to be conservative. After Blastn, fourteen complete CDS coding for different animals were chosen. According to VECTOR NIT 9.0 software, the similarities between Kunming mus musculus and bos taurus, homo sapiens, erinaceus europaeus, cricetulus griseus, sus scrofa, dasypus novemcinctus, rattus norvegicus, rabbit, equus caballus, macaca fascicularis, didelphis virginiana, monodelphis domestica and vombatus ursinus was 67%, 100%, 100%, 36%, 100%, 100%, 67%, 100%, 100%, 92%, 99%, 99% and 99%. In the phylogenetic tress constructed with the forteen 18S rRNA by Treeview, the Kunming mus musculus clustered with cricetulus griseus, sus scrofa and rabbit, which was nearer to cricetulus griseus and was most far away from macaca fascicularis.(3) After sencodary structure analyses of 18S rRNA of mus musculus, an oligonucleotide fragment for RNAi was designed and synthesized, which was transformed into plasmid, and restriction enzyme analyses and sequencing results should the expression plasmid pGPH1/ GFP/Neo-mouse-sh 18S rRNA were constructed for RNAi successfully.

结果①通过RT-PCR检测显示18S rRNA基因在小鼠卵巢组织和单个GV期、MⅠ期卵母细胞中均有表达，且在未成熟卵母细胞中，MⅠ期的表达明显强于GV期的表达；②RT-PCR产物克隆测序结果显示：昆明小鼠18S rRNA基因保守区序列与基因库序列[NR_003278保守区部分(791bp～1153bp)]完全一致；Blastn比对结果发现：在不同物种中差异较小，选出14种生物18S rRNA全序列经VECTOR NIT 9.0软件分析，提示昆明小鼠18SrRNA与牛、人类、刺猬、中国仓鼠、猪、犰狳、褐鼠、兔子、马、食蟹猴、负鼠、短尾猊、袋熊的18S rRNA的相似率依次为67%，100%，100%，36%，100%，100%，67%，100%，100%，92%，99%，99%，99%；Clustal 1.81和Treeview构建出的分子进化树表明：在上述14种生物中昆明小鼠与中国仓鼠进化关系最近，与兔子、猪聚成一簇，与食蟹猴进化关系最远；③根据18S rRNA二级结构设计并合成RNA干扰寡核苷酸片段，重组质粒经过限制性内切酶及测序表明成功构建了pGPH1/GFP/Neo-mouse-sh 18S rRNA干扰表达质粒。

The fluorescence images that RhoCr1 coordinated with Cr~(3+)in PC12 cells showed RhoCr1 to be capable of penetrating into living cells and imaging intracellular Cr~(3+)changesFive probes have been designed and synthesized,where different aldehydes were covalently linked to rhodamine B dyes with diethylamine flexible chains.

吸收和荧光光谱的测试结果表明，探针RhoCr1在Tris-HCI中性缓冲溶液中能高选择性的识别Cr~(3+)并产生了荧光增强，通过对探针光谱性能的测试和TEPN滴定实验表明，探针RhoCr1与Cr~(3+)的络合是一个可逆的过程。

These genes are related to many plant functions, indicating that the heterosis was related with many metabolization pathways.1.2 The quantity of discrepant genes showed that the genetic discrepancy was notalways the same with the discrepancy of expressed genes, indicating that small-scale genetic discrepancy maybe result in large-scale genes discrepantly expression; in other way, some genetic discrepancies might not embodied on the discrepant genes in the experiment.1.3 Nine and eight discrepant genes were found respectively in the superior bulkand minor bulk in the dominant level.

1.2 各张芯片差异表达基因数量表明遗传差异与表达谱差异不尽一致，可能较小的遗传差异可以造成表达谱的巨大改变，而有些遗传变异可能没有在表达谱上表现出来。 1.3 从优势集团和负优势集团中分别找到9个和8个具显性表达水平的差异表达基因，研究表明显性表达水平的差异表达基因的聚合与杂种优势的表现没有相关性。

The strata between the carbonate rocks of the Chaguoluoma Formation (Devonian-Early Carboniferous) and carbonate rocks of the Xiala Formation consist mainly of clastic rocks with limestone, which are marked by glaciomarine deposits in terms of sedimentation and mixing of Gondwanan and Tethyan faunas in terms of fossils.

古生物群混生的现象为石炭纪—二叠纪的特提斯生物区与冈瓦纳生物区之间的地层和古生物对比建立了一座桥梁。永珠组中上部地层中同时产有牙形石和腕足类，牙形石的研究表明其时代为晚石炭世莫斯科期，而腕足类的研究则表明其为早二叠世萨克马尔期。

The research result of the reaction between DMHAN and heptavalent technetium in nitric acid indicates that, in the studied range, DMHAN does not react with heptavalent technetium, which means that, heptavalent technetium does not directly consume DMHAN. 4, The research result of the reaction between MMH and Tc in nitric acid indicates that, this reaction is composed of three stages, induction period, fast reaction period and the termination of the reaction.

3，DMHAN和七价锝反应的研究结果表明：研究范围内，DMHAN不与七价锝发生反应，即七价锝的存在不会造成还原剂DMHAN的消耗； 4，MMH与七价锝反应的研究结果表明：MMH与七价锝的反应分为三个阶段，即诱导期、快速反应阶段和反应终止。

The transforming growth factor-β superfamily, a large group of highly conserved growth factors including TGF-βs, activins and BMPs, regulate a wide variety of cellular functions such as proliferation, differentiation, apoptosis and migration. Signals from these growth factors are transduced by a group of Smad proteins. To date, there are nine vertebrate Smads, including the receptor-activated Smads , Smadsl-3, 5 and 8, the common mediator Smad4 and Smad4β, and the inhibitory Smads, Smad6 and 7. Signaling is initiated when the ligand induces assembly of a heteromeric complex of type Ⅱ and type Ⅰ TGFβ receptors. Then R-Smads are directly phosphorylated by activated type I TGF-β receptors.

在多种SMADS中，SMAD5令我们产生兴趣，基于三个原因：1、Smad5基因敲除胚胎中发现卵黄囊的异位造血以及CFU-GM祖细胞数目增加，表明SMAD5可能是早期造血发育的负向调控基因。；2、应用反义核酸封闭Smad5可以逆转TGF-β对祖细胞增殖的抑制效应，表明它可能介导TGF-β信号转导，后者的异常，包括某些SMADS的功能异常，和白血病紧密相关；3、Smad5基因定位在人染色体5q21，此区域的缺失和急性髓系白血病和骨髓增生异常综合症相关，因此，Smad5被怀疑为白血病抑制基因。

Combined with the regional data the research indicates that (1) the Tianmenshan main body formed in the Middle Jurassic Epoch, whereas the minor body was the further differentiated and evolutive product of the main body;(2) in the Chongyi-Dayu-Shangyou ore concentrated area, the west of Gannan area, the diagenetic age and metallogenic age are basically concordant, and the mineralization concentrated during 150~155 Ma;(3) from the middle-plutonic granite intrusion to the hypabyssal granite-porphyry vein, the magmatic activities experienced only 1~5Ma, indicating there was the concentrated period of mineralization.

结合区域资料，研究表明：①天门山岩体的主体形成于中侏罗世，补体是主体进一步分异演化的产物；②在赣南西部的崇余犹矿集区内成岩与成矿的年龄基本上是协调一致的，成矿集中期为150～155 Ma；③岩浆活动由中深成相花岗岩侵入体演化到浅成相花岗斑岩脉仅相差1～5Ma，表明存在成矿集中期。

Zeta potential was -44.23 millivolt. Viscosity was 1.83 mpa. All of which were coincided with physical desire. In addition, the tests of PHGF liposomes including irritation, hemolysis, pyrogen, anomaly toxicity and hypersensibility, proved that the preparation reached the standard of intravenous injection entirely. Taking glutamic pyruvic transaminase and malondialdehyde in mice as index, studies on pharmacodynamics after hepatic injure caused by tetrachloromethane in mice indicated that GPT level (P.001) and MDA yieldment P

以小鼠CCli急性中毒性肝损伤为模型，以动物血清中谷丙转氨酶（GP水平与肝脏中丙二醛p A烨成量为指标，进行PHGF脂质体的药效学试验，结果表明P＊＊F脂质体能显著降低GP T水平o＜0刀01）与MD A 生成量厌＜o.05）；大鼠组织形态的观察表明高剂量＊＊＊F脂质体能使肝脏 0 内皮细胞增生活跃，提高肝细胞的免疫功能，对受损肝细胞具有修复作用；同样小鼠碳廓清试验也显示PHGF脂质体较市售粉针具有更好的机体免 p 疫作用o功刀01），达到制剂设计目的，获得较好的结果。

The results indicated that GLP was a linear (1→3)β-D-Glcp main chain linkage. Its monosaccharide component was predominantly composed of D-Glc, and small amount of galactose, mannose, xylose and idose, residues of branches terminated with substituted at 1→6 by a small number of singleunit β-D-Glcp side-chains, it's also observed that the (1→3)-linked β-D-glucan contained a triple-helical conformation, which was composed of a repeating unit with a structure as below:.

结果表明：灵芝多糖含有三螺旋体构型，GC-MS分析灵芝多糖的主要单糖组分为葡萄糖，还有少量的半乳糖、甘露糖、木糖和艾杜糖，IR及1HNMR分析多糖为β-构型，HIO4氧化、Smith降解和甲基化分析表明：多糖主要为(1→3)糖苷键连接构型，并伴有少量的1→6位支链键连接的结构，灵芝多糖是由D-葡萄糖单元通过β-(1→3)糖苷键连接葡聚多糖，其主要构型特征为(1→3)β-D-线性连接的骨架结构。

I am accused of being overreligious," she said in her quiet, frank manner,"but that does not prevent me thinking the children very cruel who obstinately commit such suicide.""

客人们在卡罗利娜·埃凯家里，举止就文雅一些，因为卡罗利娜的母亲治家很严厉。

Designed by French fashion house Herm è s, this elegant uniform was manufactured in our home, Hong Kong, and was the first without a hat.

由著名品牌 Herm è s 设计，这件高贵的制服是香港本土制造，是我们第一套不配帽子的制服。