表明

All enhancers did not significantly change the transcorneal lag time of ENX. The irritancy of poloxamer and Azone was observed.? The results of in vitro release studies showed that the ENX gel based 3% HPMC K4M and 3%HPMC F4M povided sustained release of the drug over an 8-h period in vitro.Diffusion area has significantly effect on drug release, and pH value of medium and rotation rate have effcet on drug release.However, the diffusion shield has no effect on drug release. The P_ value of the preparation based on 3% HPMC F4M was 1.34-fold of conventional eye drops of ENX.

体外溶出度试验结果表明，以3％的HPMC K4M和F4M为基质制备的ENX凝胶剂的体外释放行为符合眼用缓释制剂的要求；体外释放度影响因素试验结果表明，释放面积对释放度有显著性影响，pH值和转速略有影响，而扩散屏障没有影响；离体角膜透过实验结果表明，以F4M为基质制备的凝胶剂中ENX的表观渗透系数P_(app是对照组的1.34倍，说明F4M与眼角膜的相容性较好，是一种理想的眼用制剂增稠剂，可以在眼用制剂中广泛采用。

The comparisons of biochemistry between OP and OR rats The differences between OP and OR rats included not only body weight, but lipids metabolism and insulin sensitivity as well, characterized with insulin resistance, increasing in serum free fatty acids and ketone body, and hepatic TC and TG in OP rats. However, no significant differences were observed in serum TG, TC, LDL, HDL and fasting glucose between OP and OR rats.⑶Comparisons of metabolites in serum, urine and liver tissue between OP and OR rats①There were significant differences in amino acids concentration between OP and OR rats,especially in liver tissue, such as high concentrations in ketogenic and glucogenic amino acids in OP rats, suggesting differences in amino acids metabolism;② The different metabolites between OP and OR rats included increasing of various saturated fatty acids and decreasing of polyunsaturated fatty acids in OP rats;③The urinary metabolites analysis indicated that different structure or metabolism of gut microflora might exist between the two phenotypes, which probably influenced the regulation of body weight gain;④The end-products of catecholamines in urine and intermediates of krebs cycle in serum in OP rats were all up-regulated, suggesting that the activity of sympatheic nervous system and energy metabolism was higher in OP rats than OR rats.

胰岛素耐受实验和胰岛素敏感指数表明OP动物的胰岛素敏感性较OR动物下降，而OP大鼠血清中游离脂肪酸、酮体、肝脏总胆固醇和甘油三酯水平显著升高；但是，OP与OR大鼠血清中总胆固醇、甘油三酯、低密度脂蛋白、高密度脂蛋白和空腹血糖等的水平并无显著性差异；⑶肥胖易感与肥胖抵抗大鼠血清、尿液和肝脏组织提取物中代谢物的比较研究表明：①OP与OR大鼠的血清、尿液和肝组织提取物中多种氨基酸的含量存在显著差异，并以肝组织中的差异氨基酸数量为最多，包括各种生酮和生糖氨基酸水平在OP组的升高，说明氨基酸代谢的差异是两种体重表型大鼠之间存在的重要差异特征之一；②OP与OR动物肝脏和血清差异代谢物中包含多种饱和长链脂肪酸的升高如十四烷酸、十六烷酸、硬脂酸等和多不饱和脂肪酸的下降如亚油酸和花生四烯酸，说明两种体重表型动物的肝脏脂肪酸代谢存在明显差异；③长期高脂饮食喂养后，动物的尿液代谢物分析表明OP与OR动物体内的肠道菌群结构存在差异，这些菌群上的差别可能在动物体重增长的调节上产生影响；④与OR动物相比，OP动物尿液代谢物中儿茶酚胺类递质的代谢终产物如高香草酸、扁桃酸和4-羟基苯乙酸明显升高。

The heat generation curves of seven rubber materials used in tires with the changes of temperature have been obtained by using Dynamic Mechanics Analysis technique on NETZSCH DMA242 instrument, knowing that the heat generation of every other rubber materials except inner liner rubber changes lightly alone with the temperature within 10℃～80℃. According to the Fourier law, the heat transfer coefficients of tire rubber are measured by stable method on self-made experiment instrument. The coefficients changes lineally within 20℃～80℃ and the relation formulas λ=λ〓+bt are given out attached with λ〓 and b. The specific heat of tire rubber are measured on Differential Scanning Calorimeter NETZSCH DSC204 and the relations with temperature are linear and the formula is c=c〓+bT, where c〓 and b gained from experiment result data are presented in the paper. The heat convection coefficients on the surface of rolling tire are measured according to the principle of heat-mass transfer analogy principle after simplifying rolling tire into rotating disk with straight movement on wind channel. The relation with rotation speed of disk is linear as h=5. 399+0.0258n and the relation with straight line speed of tire is linear too, h=

论文采用动态力学分析技术，使用NETZSCH DMA 242型实验仪，获得了轮胎用七种胶料的生热率随温度变化曲线，确知除内衬层胶以外，其它各种胶料在一般胎温范围内（10℃～80℃）的生热率随温度变化不大；轮胎胶料的导热系数根据傅立叶定律的基本原理，采用稳态法在自行搭建的实验台上进行测试，结果表明，材料的导热系数在20℃～80℃的温度范围内随温度呈线性变化，论文给出了各种材料导热系数的线性变化的关系式λ=λ〓+bt及其λ〓和b的值；轮胎胶料的比热运用差式扫描量热原理，在NETZSCH DSC204型DSC实验仪上进行测试，结果表明，胶料的比热随温度的变化呈线性变化，其关系可用c=c〓+bT表示，文中给出了根据实验数据拟合的c〓、b的值；对轮胎表面的对流换热系数的测定，本文先将滚动的轮胎简化为有直线运动的旋转圆盘，而后采用萘升华热质比拟技术，在风洞中测量了滚动轮胎表面的对流换热系数，结果表明，圆盘表面对流换热系数与转速呈线性关系，即h=5.399+0.0258n，轮胎表面对流换热系数与其直线运动的速度呈线性关系，即h=

Based on investigating the short and intermittent structural plane, surrounding rockmass of the huge underground powerhouse in Three Gorge has been divided into five statistical similar areas according to its characteristic of rockmass structure by applying structure plane network simulation. Distributed characteristic of structural plane has been studied and based on it mechanics macrocharacteristic has been studied:(1) It is the first time that based on the result of structural plane network simulation rockmass quality of every structure area has been studied with applying blurred information optimum seeking technique and be compared with and RQD method. The result indicated that it has better effect to evaluate rock quality with blurred information optimum seeking technique.(2) It is the first time that the interrelated relationship of the result of in-suit rockmass deformation test and fractal characteristic of structure on test point has been applied to determine rockmass deformation parameter. The question of evaluating deformation parameters of engineering rockmass has been solved.(3) Anisotropy strength parameters have been determined by applying shear zones simulating method. The result indicated that there are different strength parameters in every structural area, after comparing the result of Fast Lagranian Analysis in continua number simulation method with that of method of weighted mean according to continuity. The result indicated that when a suitable reduction coefficient is been considered rockmass strength parameters can be simply and fast determined with method of weighted mean according to continuity where there is not enough test result.(4) Damage characteristic has been studied based on analysis fractal characteristic of structural plane network by applying fractal-damage coupling method. It is the first time that the concept of damage degree has been set up to evaluate rockmass quality according to the biggest principal damage.

通过对短小、断续性结构面统计特征的研究，将地下厂房区划分为五个岩体结构统计均质区，应用结构面网络模拟技术研究了各个岩体结构均质区结构面的发育分布特征，并以此为基础对岩体宏观力学特性进行了深入研究：(1)首次通过在结构面网络模拟计算结果的基础上，应用模糊信息优化技术研究了厂房区各个岩体结构分区的岩体质量并与岩体基本质量指标研究法、岩体质量指标RQD值研究法作了对比，结果表明以结构面网络模拟结果为基础，应用模糊信息优化技术进行岩体质量评价能够取得很好的效果，解决了工程岩体质量的定量评价问题；(2)首次通过对已有的现场大型岩体变形试验结果的分析及相应试验点岩体结构分形特征的研究，建立了结构面分布的分形维数和岩体变形指标间的相关关系，并首次应用这种相关关系根据结构面网络模拟及分形维数计算结果确定了缺少试验结果的地下厂房各工程部位的岩体变形指标而且应用于围岩稳定性计算，解决了工程岩体宏观变形参数的评价问题；(3)应用在结构面模拟网络图上模拟岩体剪切破坏带的方法，得出了岩体在不同方向上的强度参数，结果表明岩体的强度特性与结构面的发育方向和程度有着明显的关系，各个岩体结构均质区具有不同的强度参数；同时还通过应用拉格朗日差分法对岩体强度指标的数值分析并与按连通率加权平均计算法对比表明，按连通率加权平均计算法在考虑合理的折减系数情况下，可以简单快速地对缺少现场大型试验结果的具体工程部位实现岩体强度指标的估计，通过以上研究解决了工程岩体抗剪强度参数的评价问题；(4)通过结构面网络分形维数的研究，应用分形损伤耦合分析方法，研究了厂房区岩体的损伤特征，并首次引入"损伤度"的概念，建立了应用最大主损伤评价岩体质量的指标体系。

Problems that result from high-speed movement of the equipment in measurement unit, including image mistiness, repetition and skip, are deeply analyzed. And the processing time is tested. The result indicates that image processing algorithm is accurate, fast, and robust. The simulation result of fuzzy controller, which is gained through Matlab, indicates that the fuzzy control system can accurately determine cutter's number. The experiment of cutter indicates that the resistance thread can meet the demand.

分析了检测单元中装备高速作业带来的图像模糊和重复遗漏问题，测试了图像处理算法的时间，结果表明设计的算法准确、快速、适应性强；利用Matlab对模糊控制算法进行仿真，仿真结果表明控制算法能准确地确定刀具编号；切破刀具的试验表明设计的电阻丝刀具能满足要求。

The result indicated that the percentage of lymphocyte were decreased, the percentage of neutrophile granulocytes were magnified significantly with the lighting time increasing, which was due to the level of the melatonin inhibited in the long time lighting; and to supply different exogenous dose, induce the percentage of lymphocyte were magnifying, the percentage of neutrophile granulocytes were decreased. And the statistical analysis showed there was significant difference.

结果表明：在给予不同光照时间的条件下，随着光照时间的延长，褪黑素的分泌水平受到抑制，导致具有特异免疫功能的淋巴细胞百分率下降，具有非特异免疫功能的中性粒细胞百分率上升，经统计分析表明不同组间的测定结果均存在显着差异；采用24h全天光照，用以模拟机体切除松果腺的情况，再给予一定剂量外源性褪黑素，导致机体内具有特异免疫功能的淋巴细胞百分率上升，具有非特异免疫功能的中性粒细胞百分率下降，经统计分析表明不同组间的测定结果均存在显著差异，并且高剂量褪黑素对机体的影响更为明显。

The Molar conductivity indicates that all the complexes are nonelectrolyte. IR spectra show the ligand is bonded with RE ion through its oxygen atom in hydroxyl group of phenol; NO3 is coordinated as a symmetrical chelating bidentate group; the coordinated atoms of DMF and DMSO are the oxygen atoms in carbonyl and sulfoxyl groups. Fluorescence spectrum suggests that the Tb3+complexes have characteristic luminescence and its fluorescence intensity is enhanced after doping with La3+, Gd3+, Y3+, influence of doping ions and neutral ligands have also been discussed.

摩尔电导率表明，所有配合物均为非电解质；红外光谱及核磁共振氢谱表明，对叔丁基杯[8]芳烃通过酚羟基的氧原子与稀土离子配位；硝酸根为双齿螯合配位；DMF和DMSO则分别通过羰基氧和亚砜基氧与稀土离子配位；配合物的荧光光谱表明，所有Tb的配合物具有较强的特征荧光，掺杂La~(3+)、Gd~(3+)、Y~(3+)离子对Tb~(3+)的荧光有较强的增强作用。

Even in natural philosophy, there is always some other explanation possible of the same facts; some geocentric theory instead of heliocentric, some phlogiston instead of oxygen; and it has to be shown why that other theory cannot be the true one: and until this is shown, and until we know how it is shown, we do not understand the grounds of our opinion.

即使在自然哲学当中，对于同一事实也可能有另种解释：例如有以地球中心说代替太阳中心说的，有以热素论代替氱气论的；这就必须能够表明为什么那个另一说不能成为真理；除非到这一点已经得到表明，并且我们也知道它是怎样得到表明的，我们就不算懂得我们所持意见的根据。

It also shows that studying those associates would enhance semantic, but not perceptual processing of lures which verifies the discrepancy-attribution hypothesis.2, Compared with those emotional lures and associations in the unrelated lists, participants produce significant false recognition of emotional lures, even though initially no emotional lures appeared in the phonetic or pictophonetic relatedness effects.3, Participants show no significant difference to the emotional and nonemotional lures after studying phonetic or pictophonetic associations of single character Chinese, while phonetic relatedness effects of two-character Chinese words in the phonetic shows.

而本研究试图系统的探讨汉字关联效应中对情绪诱词的错误再认情况，本研究的结果表明： 1、在语义关联下，被试对中性、正性、负性的关键诱词都引发了很高的记忆错觉，表明这种实验范式对未出现的关键诱词的诱发错误再认是很强烈的；同时实验结果表明，对学过词表的关键诱词的知觉加工没有促进，而促进了对关键诱词的概念加工，验证了差异归因假设。

Shenyang Research Institute of Chemical Industry, Shenyang 110021, China Abstract: Spectrophotometric analysis showed that the peak absorbance for food dye of Allura Red and biological dye of Ponceau-G occurred at 501 and 510 nm. In sunlight after 2, 4, 6, 8, 10 hours, the decomposition rates of Allura Red and Ponceau G were between 2.4 to 5.8% and 3.4 to 10.8%, so they are stable in sunlight. The recovery rates on cottons and glasses were very high, so they are easily recoveried from targets. Further studies showed that the recovery rates of two dyes on the leaves of wheat, cabbage, cucumber and tomato were different, so it need previously determine the recovery rate of tracer on the target crop to adjust the result. Field experiment showed it was easy to measure the pesticide spray distribution of high volume spay and low volume spray to use Allura Red and Ponceau-G as tracers.

沈阳化工研究院，沈阳 110021 摘要：光谱分析表明，食品染色剂诱惑红和生物染色剂丽春红-G的最大吸收波长分别为501 nm和510 nm ；在连续2、4、6、8、10 h阳光照射下，分解率分别在2.4%~5.8%和3.4%~10.8%之间，见光稳定性良好；两种染色剂在棉花叶片和玻璃片上的洗脱回收率都很高，说明易于从靶标上洗脱下来；进一步测定表明，两种染色剂在小麦、甘蓝、黄瓜、番茄叶片上的洗脱回收率各不相同，所以对准备进行测试的作物应先做一次洗脱回收率试验，用以校正测试结果；田间应用表明，用两种染色剂做示踪剂，可以方便地测定常量喷雾和低容量喷雾过程中农药在麦田的沉积分布情况。

The absorption and distribution of chromium were studied in ryeusing nutrient culture technique and pot experiment.

采用不同浓度K2CrO4(0，0.4，0.8和1.2 mmol/L)的Hoagland营养液处理黑麦幼苗，测定铬在黑麦体内的亚细胞分布、铬化学形态及不同部位的积累。

By analyzing theory foundation of mathematical morphology in the digital image processing, researching morphology arithmetic of the binary Image, discussing two basic forms for the least structure element: dilation and erosion.

通过分析数学形态学在图像中的理论基础，研究二值图像的形态分析算法，探讨最小结构元素的两种基本形态：膨胀和腐蚀；分析了数学形态学复杂算法的基本原理，把数学形态学的部分并行处理理念引入到家实际应用中。