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In addition, epitope-based vaccines can be easily distinguished from wild-type viruses, which facilitate the eradication of virial diseases.

而噬菌体展示技术作为近年来新兴起的研究蛋白质抗原表位的有利工具,已经成功地鉴定出了多种病原微生物的抗原表位

The key point for constructing the novel recombinant exotoxin fusion protein B7-PE40 KDEL was to preserve the molecular biology characteristics of themselves, such as flexibility, antigenicity, hydrophilicity, epitope and secondary structure and to enhance their cytotoxic activity.

分子构建成功新型重组B7-PE40KDEL融合蛋白的关键在于,要使所构建的B7-PE40KDEL能分别保留B7-1、B7-2和PE40KDEL各自的表位特征、没有新的抗原表位产生、柔性接头处具有极低的抗原性以及具有更强的杀伤效力。

The results indicated that epitope spacer was important for a good immunogen.

这暗示表位之间的间隔序列影响了表位的呈递。

We found that antibodies specific for restricted mutant epitopes could be induced with the immunogen harboring these epitopes, which suggested a way to overcome this kind of variation.

研究发现含有限制性变异表位的重组疫苗能够诱导出限制性变异表位特异性的抗体,这提示该疫苗具有对付病毒限制性变异的能力。

For the epitope analysis, mAb 2A9 was used to react with the fusion protein by Western blot.

结果摘要: B细胞表位猜测结果显示,hMCCP的N 端第1~202位氨基酸含有多个潜在的B细胞表位

Antigenic protein vaccines contain many CD8~+ T cells epitope and CD4~+T cells epitope, they can be presented by not only MHO I molecule but also MHC-II molecule and active immune response.

蛋白疫苗的特点是含有己知和未知的CD8~+T细胞表位和CD4~+T细胞表位,不被特定的HLA表型所限制,既可通过MHC-Ⅰ类分子途径,又可通过MHC-Ⅱ类分子途径激活抗肿瘤免疫应答,因此采用蛋白疫苗可能具有更大的临床应用意义。

In competitive ELISA,only the sera from mice immunized with these minot...

这为该表位分子基础及模拟表位疫苗的研究奠定了基础

We found that the titre of epitope specific antibody in the antisera was enhanced with increased copies of epitopes.

研究结果显示抗血清中表位特异性抗体的滴度随着疫苗中表位数目的增加而升高,说明可以利用表位重复来增强表位特异性抗体应答。

Fix meter and calibration tooling board to 34 racks test bench together, loose the lower row screw, fix the upper row screw upper. Insert 4 pieces of current binding post into terminal 1,2,3,4, embed tightly, ensure connection is well. Clamp voltage line to terminal 1, clamp neutral line to terminal 2, align optical port with pulse LED, start to calibrate.

电表连同校表工装板一起固定到34表位校表台上,表的下排螺钉打松,上排螺钉固定,4根电流接线柱插入端钮盒1、2、3、4端子内,卡紧,确保接触可靠;将电压火线夹端子1上,零线夹端子2上,光电头对准脉冲灯,开始校表。

For the epitope analysis, mAb 2A9 was used to react with the fusion protein by Western blot.

结果: B细胞表位预测结果显示,hMCCP的N 端第1~202位氨基酸含有多个潜在的B细胞表位

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