衍生物

METHODS: Based on the antitumor activity and structural feature of 8-chloroadenosine and retinoic acid, modifications were made at positions 5′ and 8,substituted cinnamoyl and benzoyl groups were bound at 8 position through amido and ester bonds, sulfonation and nitrosation at 5′-OH and its direct chlorination were conducted.

对腺苷的8位和8-Cl-腺苷的糖环羟基进行了结构改造，以酰胺键和酯键在腺苷的8位连接了具共轭基团的肉桂酰基和苯甲酰基，得到腺苷的维甲类似物；对8-Cl-腺苷的5′-羟基进行了甲磺酰化，硝基化以及氯代反应，得到了它的衍生物。

Emphasis: Aminolysis method of hydroxyl on alcohol, addition amination of epoxy alkyl, aminolysis of aliphatics haloid.

重点：醇羟基的氨解、环氧烷类的加成胺化、脂族卤素衍生物的氨解。

Two kinds of polyaspartic acid derivates, i.e. PEG-g-PAsp and PEG-g-PDEA, were prepared through the ring-opening reaction of polysuccinimide by CH3O-PEG-NH2, followed by alkaline hydrolysis and aminolysis, respectively.

通过胺端基聚乙二醇(CH3O-PEG-NH2)开环聚琥珀酰亚胺，进一步碱解和胺解制备了聚乙二醇接枝聚天冬氨酸和聚乙二醇接枝聚乙二胺基天冬酰胺两种聚天冬氨酸衍生物。

One synthetic strategy started fromγ-butyrolactone 38, from which a cyclohexadiene intermediate 30 was prepared in an overall yield of 44% in a 7-step procedure after y-butyrolactone underwent a-bromination, dehydrobromination, Diels-Alder reaction, aminolysis, benzylation, bromination and dehydrobromination, with the key step being the Diels-Alder reaction under harsh condition.

其中一个路线从γ-丁内酯38开始，连续经过α-溴化、脱溴化氢、Diels-Alder反应、胺解、苄基化、溴化和脱溴化氢共7步反应，制备了一个环己二烯衍生物30，总产率44％，关键步骤是高温高压下Diels-Alder反应。

Aminoquinoline is one of the most prominence, its beneficial effects in the management of malaria caused huge attention in the pharmacologic research. The first antimalarial for clinic use was stem from AQ, since then, plenty of new structures with higher effect have been discovered.

氨基喹啉类衍生物是其中最为显著的一种，在对抗疟疾药物的研究中受到极大关注并最早应用于临床，多年来对其深入研究也涌现了一批更高效的新结构。

A HILIC-MS/MS method was developed to determine melamine and its three derivatives, cyanuric acid, ammelide and ammeline in milk and milk powder. The milk sample was directly extracted by acetonitrile with the help of ultrasonic, and milk powder was resolved in water before extraction by acetonitrile.

建立了牛奶和奶粉中三聚氰胺及其3种衍生物（三聚氰酸、三聚氰酸一酰胺、三聚氰酸二酰胺）的亲水色谱－串联质谱检测方法(HILIC-MS/MS)。

Modified starch is the floorboard of the amylaceous ramification that passes fabricating.

改性淀粉是经过二次加工的淀粉衍生物的总称。

The X-ray structures of the crystals of bovine pancreatic β- trypsin soaked with amylamine as a probe were studied and compared in cydohexane and aqueous solution, respectively.

巫广腾；黄其辰；朱广宇；钱民协；唐有祺摘要：丝氨酸蛋白酶是有机溶媒中研究酶促反应的主要对象之一。其中的胰蛋白酶在生物体内有重要的作用，对其抑制剂如苯甲脒衍生物的研究可应用于治疗很多疾病。

A series of N -bonded donor-acceptor derivatives of phenothiazine containing phenyl, anisyl, pyridyl, naphthyl, acetylphenyl, and cyanophenyl as an electron acceptor have been synthesized.

合成了一系列的N10位取代的吩噻嗪给体受体衍生物，这些受体基团包括苯，苯甲醚，吡啶，萘，苯乙酮和苯甲腈。

Under high dilution,the cross-coupling reactions of 4,5-dicyano-1,3-dithiol-2-one(6) and dithia crown-ether annulated tetrathiafulvalenes(3a～3c) in toluene gave asymmetrical dicyano tetrathiafulvalene derivatives(7a～7c) in the presence of triethyl phosphite.The compounds 7a～7c were characterized by(~1HNMR,EA,MS and IR.

在甲苯溶液中，在亚磷酸三乙酯存在下，采取高度稀释的方法，使4，5-二氰基-1，3-二硫杂环戊二烯-2-酮分别和多缩硫杂冠醚进行交叉偶联反应，成功地得到了不对称的2，3-二氰基四硫富瓦烯衍生物。

Breath, muscle contraction of the buttocks; arch body, as far as possible to hold his head, right leg straight towards the ceiling (peg-leg knee in order to avoid muscle tension).

呼气，收缩臀部肌肉；拱起身体，尽量抬起头来，右腿伸直朝向天花板（膝微屈，以避免肌肉紧张）。

The cost of moving grain food products was unchanged from May, but year over year are up 8%.

粮食产品的运输费用与5月份相比没有变化，但却比去年同期高8％。