衍生物

The present invention is directed to substituted propylamine derivatives of formula I or a pharmaceutically acceptable salt thereof, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms, sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromylagia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, and combinations thereof.

本发明涉及式I的取代丙胺衍生物或其医药学上可接受的盐、含有这些衍生物的组合物、和其用于预防和治疗通过单胺再摄取改善的病状的使用方法，所述病状尤其包括血管舒缩症状、性功能障碍、胃肠道和泌尿生殖道病症、慢性疲劳综合症、纤维肌痛综合症、神经系统病症和其组合，特别是那些选自由严重抑郁症、血管舒缩症状、压力性和急迫性尿失禁、纤维肌痛、疼痛、糖尿病性神经病变和其组合组成的群组的病状。

The charges on the substituents affected OWF〓 greatly for some azobenzene derivatives, pyridone derivatives, nitrodiphenylamine derivatives, some reactive dyes and 1, 4-diamino anthraquinone derivatives, in this instance, OWF〓 changed linearly with the change of the charges.

2给电子取代基或吸电子取代基的电荷对OWF〓有较大的影响，OWF〓随电荷的变化而线性变化，如某些偶氮苯衍生物、吡啶酮类染料母体、硝基二苯胺类化合物、偶合组分和重氮组分之间夹角α变化不大的活性染料、1，4—二氨基蒽醌衍生物等。

The polycondensation of the benzoguanamine and pyromellitic Dianhydride was carried out under microwave irradiation, and the resulted polyamic acid was grafted with TDI-para position substitution aniline derivatives. Thus graft polymers with different electronic effect of the end group in side chain were obtained.

将微波辐射合成的苯代三聚氰胺-均苯四酸二酐体系的PAA与TDI-对位取代苯胺衍生物反应，通过改变TDI－对位取代苯胺衍生物的对位取代基来合成具有不同电子效应的侧链端基的接枝聚合物。

Take the melting point of the dry solid semicarbazone derivative and record the yield. If it is necessary to recrystallize the semicarbazone derivative, you may do so from an ethanol/water mixture.

测定干燥的缩胺基脲衍生物的熔点，并记录其产量，如果有需要将缩胺基脲衍生物进行再结晶的话，你可以用乙醇/水的混合物来进行。

Take the melting point of the dry solid semicarbazone derivative and record the yield. If it is necessary to recrystallize the semicarbazone derivative, you may do so from an ethanol/water mixture.

测定乾燥的缩胺基脲衍生物的熔点，并记录其产量，如果有需要将缩胺基脲衍生物进行再结晶的话，你可以用乙醇/水的混合物来进行。

The silanol groups of silica, is reacted with various silane reagents to produce covalently bound silyl derivatives covering a varying number of active sites on the surface of the support.

担体的表面，如，硅胶的硅烷醇基团，和不同的甲硅烷试剂反应制备共价键甲硅烷基衍生物，此衍生物在担体表面覆盖了许多不同的活性点。

Chiral 3 methy 1,4 butanediol and its derivatives are the important intermediate of synthesis of chiral smectic liquid crystal polyesters and chiral natrual products with biological activity. In the paper, a new efficient route of 3 methyl 1,4 butanediol and its two derivatives, 2 methyl 4 tetrapyranyloxy 1 butanol and 2 methyl 4 tetrapyranylbutanal, was described, and the target products were synthesized by employing asymmetric hydroboration oxidation improved.

手性2－甲基－1，4－丁二醇及其衍生物是合成各种手性近晶型液晶材料以及手性天然生物活性物质的重要中间体，以3－甲基－3－丁烯－1－醇为原料利用改进的不对称硼氢化－氧化反应，成功地合成了－2－甲基－1，4－丁二醇以及其2种手性衍生物：－2－甲基－4－四氢吡喃氧基－1－醇和－2－甲基－4－四氢吡喃氧基丁醛。

Inhibition of polyamines concentrations is one of the new directions to look for anticancer drugs. Mitoguazone is structurely related to polyamines and it inhibits the cellular concentrations of polyamines.

由於 mitoguazone 为多胺类结构衍生物可降低细胞内多胺类浓度，而此机转已成为抗癌药品发展新方向之一，目前陆续合成的新衍生物其各项特性皆会与 mitoguazone 做比较。

Four phenanthroline derivatives of 2-phenyl-imazole [5,6-f]-(1,10) phenanthroline, 2-(4-hydroxy-phenyl)-imazole [5,6-f]-(1,10) phenanthroline, 2-(4-methoxyl-phenyl)-imazole [5,6-f]-(1,10) phenanthroline and 2-(4-formacyl-phenyl)-imazole [5,6-f]-(1,10) phenanthroline were synthesized, and twelve new complexes of europium were then synthesized with these phenanthroline derivatives as the first ligand and butyric acid, n-heptanoic acid and tetradecanoic acid as the second ligand.

合成2-苯基咪唑并[5，6-f]邻菲咯啉，2-（4-苯酚）咪唑并[5，6-f]邻菲咯啉，2-（4-甲氧基苯基）咪唑并[5，6-f]邻菲咯啉和2-（4-甲酰基苯基）咪唑并[5，6-f]邻菲咯啉等4种邻菲咯啉衍生物，并分别以其为第一配体，选择丁酸，正庚酸和十四酸为第二配体合成12种新的铕－邻菲咯啉衍生物－脂肪酸荧光配合物。

Four phenanthroline derivatives of 2-phenyl-imazole [5, 6-f]-(1, 10) phenanthroline, 2-(4-hydroxy-phenyl)- imazole [5, 6-f]-(1, 10) phenanthroline, 2-(4-methoxyl-phenyl)-imazole [5, 6-f]-(1, 10) phenanthroline and 2-(4-formacyl -phenyl)-imazole [5, 6-f]-(1, 10) phenanthroline were synthesized, and twelve new complexes of europium were then synthesized with these phenanthroline derivatives as the first ligand and butyric acid, n-heptanoic acid and tetradecanoic acid as the second ligand.

摘 要：合成2-苯基咪唑并[5， 6-f]邻菲咯啉，2-(4-苯酚)咪唑并[5， 6-f]邻菲咯啉，2-(4-甲氧基苯基)咪唑并[5， 6-f]邻菲咯啉和2-(4-甲酰基苯基)咪唑并[5， 6-f]邻菲咯啉等4种邻菲咯啉衍生物，并分别以其为第一配体，选择丁酸，正庚酸和十四酸为第二配体合成12种新的铕-邻菲咯啉衍生物-脂肪酸荧光配合物。

On the other hand, the more important thing is because the urban housing is a kind of heterogeneity products.

另一方面，更重要的是由于城市住房是一种异质性产品。

Climate histogram is the fall that collects place measure calm value, cent serves as cross axle for a few equal interval, the area that the frequency that the value appears according to place is accumulated and becomes will be determined inside each interval, discharge the graph that rise with post, also be called histogram.

气候直方图是将所收集的降水量测定值，分为几个相等的区间作为横轴，并将各区间内所测定值依所出现的次数累积而成的面积，用柱子排起来的图形，也叫做柱状图。