衍生物

The acyl derivatives all exhibited higher inhibitory effect than prinsepiol, among which isobutyryl and diacetate derivatives exhibited highest activity with EC50 of 3.85 mg/L and 5.60 mg/L respectively.

在Prinsepiol 4，4'位引入不同酰基后化合物的抑菌活性均有不同程度提高，其中4，4'-二异丁酰基衍生物和4，4'-二乙酰基衍生物的抑菌活性均较好，有效中浓度(EC50)分别为3.85和5.60 mg/L，是Prinsepiol的6~8倍。

Based on this core reaction, two significant libraries of isoxazole and triazole substituted methane derivatives and triazole substituted triazine derivatives were synthesized concisely from the inexpensive and readily obtainable small molecular starting materials which had been used in previous two chapters mostly.

以此为核心，以价廉易得的小分子原料通过数步反应，分别合成了异噁唑、三氮唑杂环取代的甲烷衍生物和三嗪联三氮唑杂环衍生物这两个比较有意义的小分子化合物库，达到了分子的多样化。

An overview of the pharmacological effects of lycorine and its derivatives is given, and advice for further research of lycorine and its derivatives is suggested.

综述了石蒜碱及其衍生物的药理作用研究概况，并就开发石蒜碱及其衍生物提出了建议。

For the first time, enantiomers of C2-symmetric 1,1 -spirobiindane-7,7'-diol were resolved with crude menthyl chloroformate by phase-transfer catalysis in the presence of tetrabutylammonium bromide. The reaction was carried out at 0℃-rt. The diastereomers of SPINOL bis-menthyl carbonate can be separated by simple crystallization using alcohol. The hydrolysis of the diastereomers was carried out via aqueous NaOH/EtOH solution.

首次通过相转移催化的方法对螺双二氢茚二酚进行了有效的拆分，用L--氯甲酸薄荷醇酯做拆分剂，以四丁基溴化铵为催化剂在0℃-室温下进行酯化反应生成非对映体衍生物，以乙醇作溶剂，通过重结晶的方法分离衍生物，在水-乙醇混合溶剂条件下，用强碱NaOH或KOH分别水解，制得相应的光学纯度大于99%ee的两个异构体SPINOL，其中总收率：--SPINOL，78.2%；--SPINOL，80.6%。

With the development of experimental technology and people's further knowledge to explore the biological activity of resveratrol, resveratrol derivatives and their analogues were found in grape and many other plants, which were thought to be the metabolizable products of resveratrol.

随着白藜芦醇生物活性的深入认识和实验技术的不断更新，人们在葡萄等多种植物中发现了白藜芦醇衍生物及其类似物，这些衍生物和类似物被认为是白藜芦醇的代谢产物。

With the development of experimental technology and people's further knowledge to explore the biological activity of resveratrol, resveratrol derivatives and their analogues were found in grape and many other plants, which were thought to be the metabolizable products of resveratrol.

随著白藜芦醇生物活性的深入认识和实验技术的不断更新，人们在葡萄等多种植物中发现了白藜芦醇衍生物及其类似物，这些衍生物和类似物被认为是白藜芦醇的代谢产物。

In the paper, a series of metallorganic compounds have been studied by the quantum-chemical calculation with proper basis sets, including:1. a series of carbonyl complexes.2. dibenzene chromium and its derivatives3. ferrocene and its derivatives4. a series of metallic complexes with acetylacetoneWe optimized the geometric configurations of a series carbonyl complexes including Ni4 Fe5, Cr6 with density functional theory B3LYP method at the different levels and confirmed the stable geometry by vibrational analyses. Then we calculated the nuclear magnetic resonance spectra with GIAO method provided by GAUSSION98 program at the different levels.

本文用量子化学计算程序，用密度泛函B3LYP方法，在恰当基组水平上，用GAUSSIAN98程序提供的GIAO方法研究了系列金属有机化合物的核磁共振谱：一、羰基配合物系列：二、二苯铬及其衍生物系列：三、二茂铁及其衍生物系列：四、乙酰丙酮的配合物系列：我们用密度泛函B3LYP方法，在不同基组水平上对第一过渡系羰基化合物的系列配合物进行了结构优化，通过振动分析确定其稳定构型，然后再用密度泛函B3LYP方法在不同基组水平上，用GAUSSIAN98程序提供的GIAO方法计算其核磁共振谱。

In present paper, the progress of quinoline derivatives in synthesis and application are summarized first, then according to a lot of literature, designed the synthetic route for 8 derivatives of 6-AQ. They are 4-chloro-6-AQ, 5- chloro -6-AQ, 5-methoxyl-6-AQ, 7- chloro -6-AQ, 8- chloro -6-AQ, 8-bromo-6-AQ, 8-methyl-6-AQ and 8- methoxyl -6-AQ. All the products were obtained by reduction of its corresponding 6-nitroquinoline.

在对过往文献大量查阅的基础上，本文首先综述了喹啉及其衍生物的性质、合成方法及应用研究进展，并通过对文献报道方法的优化和改进成功地设计合成了4-氯-6-AQ、5-氯-6-AQ、5-甲氧基-6-AQ、7-氯-6-AQ、8-氯-6-AQ、8-溴-6-AQ、8-甲基-6-AQ和8-甲氧基-6-AQ等8种6-AQ的衍生物作为研究新型抗疟疾药物的中间体。

Valine and nitroxyl functional group were introduced into amino-substituted TPP respectively, and photocytotoxicities of the resulting porphyrins were tested.

以单氨基TPP为原料，分别将缬氨酸、氮氧自由基衍生物引入TPP分子，初步考察了两种TPP衍生物对肿瘤细胞和正常细胞的光毒性。

The melting temperatures of these derivative s are easily determined and are characteristic for each osazone.

这些衍生物的熔点温度很容易确定，而且对每一种衍生物是特征性的。

On the other hand, the more important thing is because the urban housing is a kind of heterogeneity products.

另一方面，更重要的是由于城市住房是一种异质性产品。

Climate histogram is the fall that collects place measure calm value, cent serves as cross axle for a few equal interval, the area that the frequency that the value appears according to place is accumulated and becomes will be determined inside each interval, discharge the graph that rise with post, also be called histogram.

气候直方图是将所收集的降水量测定值，分为几个相等的区间作为横轴，并将各区间内所测定值依所出现的次数累积而成的面积，用柱子排起来的图形，也叫做柱状图。