衍生物

Liaoning Medical University, Jinzhou 121001 China）Abstract:Objective To study the distribution and liver targeting of glycyrrhetinic acid derivatives (stearin glycyrrhetinic acid ester-3-O-galactosidase, Gal-GAOSt) modifying norcantharidin liposomes (Gal-GAOStNC-LP) in rats.

目的 研究甘草次酸衍生物（甘草次酸硬脂醇酯-3-O-半乳糖苷，Gal-GAOSt）修饰去甲斑蝥素脂质体(Gal-GAOStNC-LP)在小鼠体内的分布及肝靶向性。方法利用薄膜分散法制备甘草次酸衍生物修饰去甲斑蝥素脂质体后，经小鼠尾静脉给药，采用HPLC法检测去甲斑

A series of cholesterol-bearing O-carboxylmethyl chitosan conjugates with different degrees of substitution of the cholesterol moieties and cholesterol-bearing chitosan were synthesized by the succinyl linkages and characterized by Fourier transform infrared, Proton Nuclear Magnetic Resonance (~1H NMR) and elemental analysis. These hydrophobized chitosan derivatives were amphiphilic in nature and their self-aggregation behavior in aqueous media was evaluated by the fluorescence probe technique.

课题的主要研究内容如下：采用化学的方法合成了不同分子结构、不同取代度的系列胆甾醇基壳聚糖衍生物—胆甾醇基壳聚糖和胆甾醇基-羧甲基壳聚糖，并应用先进的分析手段电位滴定、红外光谱法(IR、核磁共振波谱法等对原料、中间产物以及产物进行了结构表征，衍生物分子中的胆甾醇基取代度(3.2％～12.5％)采用元素分析的方法进行检测。

One new hydroxypropyl hydroxyethyl starch derivative with fine thermoplasticity ,of which glass temperature T g≈140℃ and flow temperature T f≈170℃,was prepared when corn starch was properly coupled with epichlorohydrin then hydroxypropylated and hydroxyethylated in high substitution values.

以淀粉衍生物作为添加剂与非降解性塑料等复合制备可降解材料时，淀粉衍生物的热塑性是一项非常重要的指标。

The chapter 3 focuses on the design and synthesis of new thiazole derivatives.

论文第四章是噻唑衍生物的固相合成，设计并开发了用组合化学方法合成噻唑衍生物的新方法。

The synthesis of thiazole ,imiadzole,oxazole and their derivatives were stress introduced.

综述了近几年来五元杂环化合物的研究进展，重点介绍了噻唑、咪唑、唑等衍生物的合成进展，并展望了这3类衍生物的发展前景。

Study on the Synthesis of Uracil Derivatives Ⅱ.Study on the Synthesis of 1, 4-Dihydro-s-Tetrazine Derivatives and Their Antitumor Activity

论文标题：Ⅰ。药物中间体尿嘧啶衍生物合成研究Ⅱ。1，4-二氢-s-四嗪衍生物的合成及抗肿瘤活性研究

In a particular embodiment, a crop protection composition comprises a mononucleate solid crop protection particle coated with either wood rosin, rosin derivatives, waxes, fatty derivatives, sterols, long-chain sterol esters and sulfur.

在具体的实施例中，农作物保护组合物包括一种用木松香、松香衍生物、石蜡、脂肪衍生物、甾醇、长链甾醇酯及硫中之一加以包被的单核固体农作物保护颗粒。

The isomerization of resin acid was studied by HCl catalysis method, high temperature catalysis method and microwave-assisted method. Separation of abietic acid was analyzed with recrystallization method and many organic amine salt methods; Using abietic acid separated from resin acid as raw materials, 6 compounds of abietic-type resin acid derivetives were synthesized.

从产率、纯度和成本等方面分析对比了改进的二戊胺盐法、A胺盐法、B胺盐法和文献报道的二戊胺盐法分离提纯枞酸；以得到的枞酸为原料，进行氧化合成，得到6种枞酸的氧化衍生物，通过柱分离得到2种枞酸氧化衍生物纯品，并测试了其抑菌和对家蝇的拒食活性。

The invention discloses a process for preparing N-Boc derivative or N-Cbz derivative of chiral alpha, alpha'-double substituent pyrrolidine which contains ethylenic link and acetylenic link substituent.

本发明公开了一种制备含烯键和炔键取代基的手性α，α'-二取代吡咯烷的N-Boc衍生物或N-Cbz衍生物的方法。

In this paper, a series of 4,5-dithiacrown ether annulated 1,3-dithiole-2-thiones 8a~8d were prepared via condensing 4,5-bis-1,3-dithiole-2-thione (7) with 1,ω-dimercapto polyglycol derivatives in high dilution. The obvious template effect was found during the synthesis of 8c-8d.

在高度稀释条件下，经4，5-二溴甲基-1，3-二硫杂环戊烯-2-硫酮(7)和多缩乙二醇的1，ω-二巯基衍生物的缩合反应，方便地合成了4，5-位带二硫杂冠醚残基的2-硫代-1，3-二硫杂环戊烯的衍生物8a~8d，中间体硫杂冠醚8c~8d的合成中有明显的&模板效应&。

On the other hand, the more important thing is because the urban housing is a kind of heterogeneity products.

另一方面，更重要的是由于城市住房是一种异质性产品。

Climate histogram is the fall that collects place measure calm value, cent serves as cross axle for a few equal interval, the area that the frequency that the value appears according to place is accumulated and becomes will be determined inside each interval, discharge the graph that rise with post, also be called histogram.

气候直方图是将所收集的降水量测定值，分为几个相等的区间作为横轴，并将各区间内所测定值依所出现的次数累积而成的面积，用柱子排起来的图形，也叫做柱状图。