血脑屏障

BACKGROUND: The copper-superoxide dismutase can not play an effective role in free radical-scavenging in the process of hypoxia or reaeration because of blood-brain barrier, whether the treating effect can be enhanced by chitosan nanoparticles is uncertain.

背景：由于血脑屏障的存在，铜超氧化物歧化酶在临床应用中往往达不到其在体外对中枢神经细胞缺氧、复氧过程中的自由基清除效果。那么能不能利用壳聚糖纳米粒这一种新的基因载体来增强铜超氧化物歧化酶的治疗效果呢？

OBJECTIVE: To establish a relatively simple,reliable and reproducible in vitro model of the blood brain barrier.

目的：建立一种相对简单可靠、接近在体状态的SD大鼠体外血脑屏障模型。

Compare with microparticle, nanoparticle possesses several advantages, such as ultramicroscopic size, could be ingested by the cells after crossing the tissue matrix, and can penetrate the arterial wall and cross the blood-brain barrier.

它与微米粒子的主要区别是超微小体积，能穿过组织间隙并被细胞摄取，可通过毛细血管壁和血脑屏障，因而作为一种新的控释体系而被广泛研究。

Objective To evaluate the therapeutic effects of aminoguanidine on cerebral ischemia-reperfusion damage in rats.

目的 探讨氨基胍对大鼠脑缺血再灌注后的血脑屏障的影响及对再灌注损伤的保护作用。

Counteracting it and it's decomposed peptide into brain and interacting with H22 cell and spleen cell.

我们应用〓-CNB研究了B亚基的血脑屏障通透性和B亚基与H22肝癌细胞，脾细胞的相互作用。

To investigate the hyperglycemic effect on ICAM-1 expression of BBB, we took a dynamic observation of the expression on endothelium of BBB in SD rats with hyperglycemia for 3 days to 6 months, by immunohistochemical method.

为了解超负荷血糖条件下有否血脑屏障内皮细胞ICAM-1的表达，本研究采用SD大鼠尾静脉注射链脲霉素的方法，建立超负荷血糖模型。

Antecedent trial, SAINT I, and the critical commentary stimulated by it, which called attention to its interpretively challenging primary outcome measure—a shift in the full-scale modified Rankin scale score—and to other statistical shortcomings;(2) the cogency of the STAIR recommendations, to which the development of NXY-059 closely adhered; and (3) the inherent physiochemical shortcomings of NXY-059 as a neuroprotective agent—its polar, nonlipophilic nature, poor blood– brain barrier penetrability, nonphysiological oxidation potential, and low potency.

应注意SAINT I期试验有争议的结局指标以及统计方法的缺陷；（2）NXY-059试验严格遵守STAIR推荐；（3）NXY-059作为神经保护剂固有的生理生化性质的缺陷：该药的极性、非脂溶性、较差的血脑屏障穿透性、无生理性的氧化能力以及低效价。

In 1994 and again, in 2002, Dr. Leif Salford from Lund University in Stockholm, Sweden found in his studies that rats exposed to cell phone radiation showed a breakdown in the blood brain barrier, as well as areas of shrunken, damaged neurons .

在1994年再次在2002年，雷夫索尔福德博士从瑞典隆德大学在瑞典首都斯德哥尔摩发现在他的研究，老鼠暴露于手机辐射的细目显示，在血脑屏障，以及领域的萎缩，神经细胞受损。

Methods The high blood sugar animal model was induced by intraperitoneal injecting streptozotocin; the MACO model was made by the thread occlusions.

采用链脲佐菌素腹腔注射复制高血糖模型；线栓法制作大脑中动脉栓塞模型；应用免疫组化技术观察MMP-9蛋白表达，并测血脑屏障的通透性。

All of the neurotherapeutics that are used in clinical practice at present are small lipid soluble molecules that can diffuse through the BBB. Yet these drugs can no longer meet the clinical needs, many brain neurotherapeutics and neuroprotective drugs are large, water soluble molecules.

临床上采用的中枢神经系统药物大多是能够扩散通过血脑屏障的小分子脂溶性物质，而这类药物已经远远不能满足临床需要，很多疾病的诊断、治疗需要大分子、水溶性物质。

Finally, according to market conditions and market products this article paper analyzes the trends in the development of camera technology, and designs a color night vision camera.

最后根据市场情况和市面上产品的情况分析了摄像机技术的发展趋势，并设计了一款彩色夜视摄像机。

Only person height weeds and the fierce looks stone idles were there.

只有半人深的荒草和龇牙咧嘴的神像。