血缺氧

Vinpocetine is effective in curing cerebrovascular diseases, which can selectively improve the circulation of brain, promote energy metabolism, regulate the system function of neurotransmitter, protect brain from suffering from damage due to ischemia and anoxemia in many ways, be used in treatment of insufficiency in blood - supply, stroke and symptoms related to aging, and have special effect on recognition and memory.

长春西汀治疗脑血管病的有效药物，它能够选择性地改善大脑的血液循环，促进大脑的能量代谢，调节神经递质系统功能，多方面保护大脑免受缺血缺氧性损害，特别适用于防治脑供血不足、中风以及与衰老有关的症状，并对认知和记忆有特别的效果，目前临床应用非常广泛，现将长春西汀的药理作用及临床应用综述如下。

ObjectiveSevere traumatic patients always had a severe blood loss, for maintaining blood supply of heart and head, the gut would appear ischemic and anoxemia through the mechanisms of intestinal ischemic, reperfusion and release of mediators of inflammation and so on, which could cause functional impairment of intestinal barrier and translocation of intestinal bacterium and endotoxin, accordingly, induce the occur of SIRS (systemic inflammatory response syndrome), sepsis and MODS (multiple organ dysfunction syndrome).

目的严重创伤常伴严重失血，机体为维持心、脑的血供，肠道首先出现缺血缺氧，通过肠道缺血、再灌注、炎症介质的释放等机制，引起肠道屏障功能障碍，肠内细菌及内毒素移位，从而导致SIRS、脓毒症和MODS的发生。

(1) cerebral ischemical reperfusion injury rats'limbs motor function is variable. Acupuncture could promote lims'functional recovery.(2) PCNA masc cells is visible in cerebral ischemical semidarkness region. There is cell regeneration phenomenon. Acupuncture could strengthen injury region's PCNA expression, could profit injury recovery and functional reconstruction.(3) In ischemia semidarkness region for the model group and acupuncture group, PCNA masc cells percentage of 14days group is lower than 7days group. Along with the recovery of injury, cell multiplication is weaken.(4) In cerebral ischemia semidarkness region, there is VEGF masc cells and regeneration phenomenon. Acupuncture could strengthen injury region's VEGF expression, could profit protection after injury and blood vessel regenerate.(5) In ischemia semidarkness region for the model group and acupuncture group, VEGF masc cells percentage of 14days group is lower than 7days group. Along with the recovery of semidarkness region, ischemia and anoxemia state is getting improved, and VEGF is reduce.(6) As there are PCNA and VEGF masc cells in brain injured region, we could conclude that, after brain ischemical reperfusion injury, there are blood vessel regeneration phenomenon. Acupuncture could promote blood vessel regeneration, recovery blood supply sufficiently and quickly, and promote the recovery of brain injury region.(7)The VEGF masc cells percentage of inhibitor group is lower than acupuncture group. It state that the effect of acupuncture promote VEGF is partly depend on the existing of eNOS.

实验结论：(1)脑缺血再灌注损伤后大鼠的肢体运动功能发生改变，针刺可以促进肢体功能恢复；(2)脑缺损伤区可见PCNA阳性细胞，存在细胞再生现象，针刺可以增强损伤区PCNA的表达，有利于损伤的修复和功能重建；(3)针刺组和模型组14d时缺血损伤区PCNA阳性细胞百分比低于7d组，随着损伤逐渐得到修复，细胞增殖现象减弱；(4)脑缺血损伤区可见VEGF阳性细胞，存在内皮型细胞再生现象，针刺可以增强损伤区VEGF的表达，有利于脑损伤后保护和缺血区血管再生；(5)针刺组和模型组14d时缺血损伤区VEGF阳性细胞百分比低于7d组，随着缺血损伤的修复，缺血缺氧状态得到改善，产生的VEGF减少；(6)由于脑损伤区同时出现PCNA阳性细胞和VEGF阳性细胞，前者是增殖细胞的标志，后者是促进血管再生的重要因子，可以推断，脑缺血再灌注损伤后脑内存在血管再生现象，针刺可以促进损伤区的血管再生，更迅速而充分的恢复损伤区的血供，促进脑损伤区的修复；(7)抑制剂针刺组脑损伤区VEGF阳性细胞百分比与针刺组相比有不同程度的降低，说明针刺促进缺血损伤区VEGF表达部分依赖eNOS的存在。

AbstractObjective:to analyze the relationship between normal term newborn and the degree of asphyxiation.

目的：分析足月新生儿高胆红素血症与窒息缺氧程度的关系。

Hemolysis can be caused by fetal anemia, cardiomegaly, liver, splenomegaly, edema of the fetus and placenta, blood erythrocytosis, severe fetal hypoxia, resulting in intrauterine fetal death.

溶血可致胎儿贫血、心脏扩大，肝、脾肿大，胎儿及胎盘水肿，血液中红细胞增多，严重时胎儿缺氧，造成胎死宫内。

Hemolysis can be caused by fetal anemia, cardiomegaly, hepatosplenomegaly, edema of the fetus and placenta, blood erythrocytosis, severe fetal hypoxia, resulting in intrauterine fetal death.

溶血可致胎儿贫血、心脏扩大、肝脾肿大、胎儿及胎盘水肿，血液中红细胞增多，严重时胎儿缺氧，造成胎死宫内。

Although the pathologic changes of ICP are similar to those of placental ischemia,these alterations influenced directly the plaˉcental blood and oxygen supply function to result in bad pregnancy.

虽然ICP时胎盘病理改变与胎盘缺血缺氧时的改变相比无特异性，但形态学改变直接影响了胎盘的供血和供氧功能，导致了不良妊娠结局。

Results Compared with that of the control group, the dark adaptation time and the saturation of blood oxygen of trial group were significantly different, i.e.

高压氧干预可增加人体在高原缺氧条件下的血氧饱和度，并提高人体的暗适应能力。

The damage of hepatic kupffer cells function and intestine mucosae protective screen function caused cooperatively by ischemia, hypoxia, microcirculatory disarrangement, inflammatory mediators (O〓, OH〓 etc) and cytokines (TNF-α, IL-1, IFN-γetc), the functional damage easily results in bacterial translocation and endotoxemia, as the damage mitigates the clearance of bacteria and toxin.

缺血、缺氧、微循环障碍、炎症介质及细胞因子（TNF-α、IL-1、IFN-γ等）共同作用，使肝脏Kuppfer细胞和肠粘膜屏障功能受损，对内毒素清除能力减弱致内毒素血症，是肝功能衰竭的重要病生环节，亦是继发多脏器衰竭的始动因素，但ALF致病确切机制目前尚不十分清楚。

Fant by use of serial CK-BB isoenzyme measurement.

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This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。