血细胞生成

Can accelerate the bone marrow cell from G1 phase into S phase when we measure it's Cell cycle, it make S phase rate was increased .thus it promoted DNA synthesize and repaired. Mice irradiated at dose of 5.5 Gy gamma-irradiation showed timed-related decreases and restores in peripheral blood picture at day 1 through day 21, the counts of WBC of these group had taken drug has various degree to increase than irradiation control group in day 1. Grugs failed to protected the peripheral blood cell at lowest point, but seems promote their rescovery.9803 treated group was distinct. At 7days after mice were radiated in 3.5 Gy. we observed drug can Significantly hold back the decreased number of hematopoietic progenitors colony forming radiation induced. These findings indicated 9803 have a certain radioprotective activity against gammer irradiation in mice.

给药组的 CFU-S 数量较照射对照组明显增加，3.5Gy 照后第七天观察给药9803组对小鼠骨髓造血组细胞集落生成能力的影响，给药组的造血祖细胞集落的形成能力强于照射对照组，并且9803组明显优于523组。5.5Gy 照射引起的小鼠的外周血细胞数量的降低以 WBC 发生最早，照后24小时给药组的 WBC 数量均比照射对照组有不同程度的升高，以9803各给药组最为明显，药物未能使照射引起的外周血细胞最低值升高，而有降低的趋势，但给药对照射后期外周血象的总体恢复有较好的促进作用。7.5Gy 照射后第七天测定小鼠骨髓细胞周期的测定中发现9803具有促进骨髓细胞由 G1期进入 S 期的效应，致使 G0/G1期细胞显著减少， S 期细胞比率显著增加，这利于促进 DNA 合成修复，即促进骨髓细胞增殖，骨髓细胞 DNA 含量给药组显著高于照射对照组。

HDAC1 has been shown to interact with many key hematopoiesis transcription fators and to influence their activities.

组蛋白去乙酰化酶在血细胞生成和白血病生成中发挥着重要的作用。

Understand hemopoiesis and the formation control.

了解血细胞的生成和生成调节。

It publishes original research reports, reviews in the following areas: cell cycle regulation, cytokines, erythropoiesis, gene therapy, general hematopoiesis, granulopoiesis, hematological malignancies, immunobiology, immunotherapy, lymphopoiesis, megakaryocytopoiesis, microenvironment, monocyte development, molecular genetics, signal transduction, stem cell biology, and experimental as well as clinical stem cell transplantation.

该杂志刊载细胞周期调控、细胞因子、红细胞生成、基因疗法、全身血细胞生成、粒细胞生成、血液肿瘤、免疫生物、免疫疗法、淋巴细胞生成、巨核细胞生成、微环境、单细胞生成、分子遗传学、信号传导、干细胞生物学、实验与临床干细胞移植方面的原始论文及综述等。

Hematopoietic stem cells are a population of cells which have potential to self-renewal and to differentiat...

造血干细胞是生成血细胞的原始细胞，它具有自我更新和多向分化特性。

This thesis, basing on clinic experience and understanding of Tradional Chinese Medicial theory about tumor's etiological factors and side-effects of chemotherapy or radiation cure, studied total saponins of Sanguisorba officinal is effects and mechanisms of action on hypocytosis induced by radiation and chemical.

本课题根据中医理论对肿瘤及放化疗毒副作用病因和病机的认识，结合中医临床经验，以传统止血中药地榆为研究对象，在已有的研究基础上针对放、化疗致血细胞减少症，采用现代药理学研究方法和细胞学及分子生物学研究方法，深入探讨地榆总皂苷促血细胞生成的作用及分子机理。

TSPG has the similar effect as HGFs, can directly or/and indirected effect and regulate proliferation and differentiation of CD34〓 HSC/HPC to bring into full play in"invigorating qi"of Panax ginseng. 2. During the process of the extensive proliferation, orderly differentiation, functional activation and gene transfer of hematopoietic stem/progenitor cells in ex vivo culture systems, TSPG may be used to regulate the proliferation and differentiation of hematopoietic cells to perform potential application in the domain of hematpoietic stem cell engineering.

我们的研究结果提示：1、TSPG具有类似造血生长因子的功效，能直接或间接影响和调控造血干/祖细胞的增殖与分化，促进血细胞的生成，从而发挥人参&补气生血&之功效。2、在进行对造血干/祖细胞的扩增与诱导分化，功能激活，基因转染等造血干细胞工程研究中可利用人参皂甙的药理作用来调控细胞的增殖分化，发挥其在造血干细胞工程领域的潜在应用价值。

Our previous studies have shown that ubiquitous overexpression of HmgD caused hemocytes proliferation and the formation of melanotic tumors in the Drosophila larvae. To clarify the mechanism of melanotic tumors appearance,we also generated RT-PCR analysis to test the transcriptional changes of PPAE and Spn27A,which encode the key factors in the phenoloxidasecascade pathway from larvae samples of mid-third instar,late-third instar and prior to pupation relative to wild type flies.Our result showed that in the HmgD overexpression mid-third instar larvae,the expression level.of Spn27A was lower than wild type,otherwise the expression level of PPAE was higher than wild type.It suggests that overexpression of HmgD affects the PO cascade pathway.

本研究组前期工作发现，过量表达HmgD引起果蝇幼虫体内血细胞增生，并出现黑色素瘤，为探讨HmgD过量表达导致了血细胞增生即形成黑色素瘤的分子机制，本研究分别提取三龄中期、后期和相对于野生型化蛹前时刻的幼虫的RNA，首先检测了编码酚氧化酶级联反应途径中的两个关键基因PPAE，Spn27A在突变体中的转录发生变化，结果发现，Spn27A在三龄中期的表达量低于野生型，而PPAE的表达高于野生型，表明过量表达HmgD影响了酚氧化酶级联反应途径，低水平的Spn27A不足以抑制PPAE的活性，活化的PPAE催化了PPO的活性，使其转变成有活性的PO，从而促进黑色素的生成，使果蝇体内产生黑色素瘤。

| The culmination of decades of research on humanized mice is leading to advances in our understanding of human haematopoiesis, innate and adaptive immunity, autoimmunity, infectious diseases, cancer biology and regenerative medicine. In this Review, we discuss the development of these new generations of humanized mice, how they will facilitate translational research in several biomedical disciplines and approaches to overcome the remaining limitations of these models.

对人化小鼠的几十年的研究，使我们对人血细胞生成，固有免疫，获得性免疫，自身免疫，感染性疾病，癌症生物学和再生医学有了进一步的理解，在这篇综述中我们讨论了人化小鼠新世代的发育，它们怎样在若干生物医学学科中促进translational research的发展，和克服这些模型局限性的方法。

Erythropoietin is a cell factor of regulating haematopoiesis, recently study discover that EPO and EPOR widespreadly exist in central nervous system,both boinding possessed nerve growth,neurotropy and neuroprotective effect,whose mechanism was complicate and not clear.

促红细胞生成素(erythropoietin，EPO)是一个调节血细胞生成的细胞因子，近来发现EPO及其受体在中枢神经系统中广泛存在，二者结合后具有促进神经生长、神经营养和神经保护作用，但其具体作用机制较复杂，仍然不十分清楚。

In the United States, chronic alcoholism and hepatitis C are the most common ones.

在美国，慢性酒精中毒，肝炎是最常见的。

If you have any questions, you can contact me anytime.

如果有任何问题，你可以随时联系我。