血细胞发生

It is concluded that the initial ancotomic site of blood island genesis may be is mesoblast of extraembryonic blastoderm rather than the yolk sac; the blood vessel endothelium cells and the blood cells are generated parallel; the PGCs are the common ancestry of angioblast and HSC.

血岛最早发生的解剖位置可能不是卵黄囊而是胚外胚盘中胚层，血管内皮细胞与血细胞平行发生，PGC是成血管－造血干细胞的共同祖先。

Thus,acute radiation sickness of moderate degree was ascertained.It was deduced that 3 other members in Feng's family died of ARS.Altogether about 100 ictims were found.Conclusion When ealuating a patient with suspicious burn without a history of contact of heat or fire and caustic chemicals and the patient has nausea,omiting,epilation and decrease in white blood cells,the possibility of radiation exposure exists.If some patients with aboe manifestations are found in a same family the radiation exposore may be more probable.

如遇到难以解析的皮肤烧伤病变，排除热或化学烧伤后，应考虑放射烧伤，对有恶心，呕吐，脱发，口腔溃疡，外周血细胞减少者，更支持诊断；如家中成员中相继发生上述同类症状者更应高度怀疑，并作相关检查确诊；简易隔简可为一般医院所采用；细胞因子可促进造血功能恢复，缩短病程。

Thus,acute radiation sickness of moderate degree was ascertained.It was deduced that 3 other members in Fengs family died of ARS.Altogether about 100 victims were found.Conclusion When evaluating a patient with suspicious burn without a history of contact of heat or fire and caustic chemicals and the patient has nausea,vomiting,epilation and decrease in white blood cells,the possibility of radiation exposure exists.If some patients with above manifestations are found in a same family the radiation exposore may be more probable.A simple isolation ward can be set in an ordinary hosiptal and GM-CSF is used to reduce the course.

如遇到难以解析的皮肤烧伤病变，排除热或化学烧伤后，应考虑放射烧伤，对有恶心，呕吐，脱发，口腔溃疡，外周血细胞减少者，更支持诊断；如家中成员中相继发生上述同类症状者更应高度怀疑，并作相关检查确诊；简易隔简可为一般医院所采用；细胞因子可促进造血功能恢复，缩短病程。

Can accelerate the bone marrow cell from G1 phase into S phase when we measure it's Cell cycle, it make S phase rate was increased .thus it promoted DNA synthesize and repaired. Mice irradiated at dose of 5.5 Gy gamma-irradiation showed timed-related decreases and restores in peripheral blood picture at day 1 through day 21, the counts of WBC of these group had taken drug has various degree to increase than irradiation control group in day 1. Grugs failed to protected the peripheral blood cell at lowest point, but seems promote their rescovery.9803 treated group was distinct. At 7days after mice were radiated in 3.5 Gy. we observed drug can Significantly hold back the decreased number of hematopoietic progenitors colony forming radiation induced. These findings indicated 9803 have a certain radioprotective activity against gammer irradiation in mice.

给药组的 CFU-S 数量较照射对照组明显增加，3.5Gy 照后第七天观察给药9803组对小鼠骨髓造血组细胞集落生成能力的影响，给药组的造血祖细胞集落的形成能力强于照射对照组，并且9803组明显优于523组。5.5Gy 照射引起的小鼠的外周血细胞数量的降低以 WBC 发生最早，照后24小时给药组的 WBC 数量均比照射对照组有不同程度的升高，以9803各给药组最为明显，药物未能使照射引起的外周血细胞最低值升高，而有降低的趋势，但给药对照射后期外周血象的总体恢复有较好的促进作用。7.5Gy 照射后第七天测定小鼠骨髓细胞周期的测定中发现9803具有促进骨髓细胞由 G1期进入 S 期的效应，致使 G0/G1期细胞显著减少， S 期细胞比率显著增加，这利于促进 DNA 合成修复，即促进骨髓细胞增殖，骨髓细胞 DNA 含量给药组显著高于照射对照组。

Haemolytic anaemia occurs when red blood cell destruction is increased as the result of an acquired or inherited condition, which generally interferes with normal red blood cell production.

溶血性贫血发生时，红细胞破坏增加的结果，一收购或继承的条件，一般会干扰正常的红血细胞的生产。

Objective To explore the effect of nerve growth factor on hematopoiesis of granulocyte-macrophage and to elucidate the underlying mechanism.

目的 探讨神经生长因子对小鼠粒－巨噬系血细胞发生的影响。

After recurrence, one patient had an irreversible humoral rejection, another died from hemophagocytosis and another restarted dialysis 1 year later.

复发后，其中有1例发生不可逆的体液性排斥，1例死于吞噬血细胞作用，1例1年后再透析。

OBJECTIVE: To observe dynamically the level of white blood cell and its morphological changes using automatic blood cell analyzer to evaluate its relationship with infection, immunosuppressive intoxation and acute rejection.

目的：应用全自动血细胞分析仪动态监测肾移植患者外周血白细胞数量和形态的变化，分析其与移植后机体感染、免疫抑制剂中毒及急件排斥反应发生的关系。

Our previous studies have shown that ubiquitous overexpression of HmgD caused hemocytes proliferation and the formation of melanotic tumors in the Drosophila larvae. To clarify the mechanism of melanotic tumors appearance,we also generated RT-PCR analysis to test the transcriptional changes of PPAE and Spn27A,which encode the key factors in the phenoloxidasecascade pathway from larvae samples of mid-third instar,late-third instar and prior to pupation relative to wild type flies.Our result showed that in the HmgD overexpression mid-third instar larvae,the expression level.of Spn27A was lower than wild type,otherwise the expression level of PPAE was higher than wild type.It suggests that overexpression of HmgD affects the PO cascade pathway.

本研究组前期工作发现，过量表达HmgD引起果蝇幼虫体内血细胞增生，并出现黑色素瘤，为探讨HmgD过量表达导致了血细胞增生即形成黑色素瘤的分子机制，本研究分别提取三龄中期、后期和相对于野生型化蛹前时刻的幼虫的RNA，首先检测了编码酚氧化酶级联反应途径中的两个关键基因PPAE，Spn27A在突变体中的转录发生变化，结果发现，Spn27A在三龄中期的表达量低于野生型，而PPAE的表达高于野生型，表明过量表达HmgD影响了酚氧化酶级联反应途径，低水平的Spn27A不足以抑制PPAE的活性，活化的PPAE催化了PPO的活性，使其转变成有活性的PO，从而促进黑色素的生成，使果蝇体内产生黑色素瘤。

Meanwhile,HDAC1 acetylation level is significantly increased.The overexpression of HDAC1 can promote erythroid cell proliferation and inhibits induced differentiation,the knockdown of HDAC1 or 2 inhibits erythroid cell proliferation and promotes induced differentiation.We also found that HDAC1 affects GATA1 mediated transcription activity.Thus our data revealed that HDAC1 may negatively regulate GATA1 mediated transcription and suggest that the dynamic regulation of GATA1 associated NuRD/MeCP1/HDAC1/HDAC2 complex may determine the onset of erythroid differentiation programs.Moreover,this study will eventually help to design new therapeutic approaches in treatment of leukemia.

研究发现在被诱导分化的小鼠红细胞白血病细胞中与GATA1相结合的HDAC1被乙酰化并失去活性，在血细胞中过表达HDAC1能够促进血细胞的增殖并抑制分化，反之在血细胞中敲除HDAC1或HDAC2能抑制血红细胞的增殖并促进分化，而且HDAC1能够负调控GATA1的转录活性，GATA1与NuRD/MeCP1复合体之间的动态调控，决定血红细胞分化的发生和发展，并为探索白血病的致病机理奠定了理论基础。

I didn't watch TV last night, because it .

昨晚我没有看电视，因为电视机坏了。

Since this year, in a lot of villages of Beijing, TV of elevator liquid crystal was removed.

今年以来，在北京的很多小区里，电梯液晶电视被撤了下来。