血管舒缩

The blood pressure of.1 of pathology physiology mechanism that SAS causes CVD breathes time-out to be able to bring about airframe in elevatory Morpheus anoxic, sympathetic is excessive and excited, element of serous catechu phenolic amine, kidney and hemal endodermis element are elevatory, bring about hemal easy of hemal convulsion; to shrink the function is disorder, can make blood-vessel flowing flesh happening reframes and fleshy, systemic blood-vessel obstruction adds element of the kidney when; is chronic and anoxic, system of hemal and nervous element is activationed, bring about blood pressure to lift. Obstruction of way of energy of life of patient of OSAS of disease of blood of 1.2 low oxygen increases, cause air current to interrupt, breath pauses, at the same time airframe gets used to low oxygen environment gradually, breathing centre drops to low oxygen and sensitivity of disease of blood of tall carbonic acid, breath suspends a frequency increasing, farther aggravating airframe is anoxic. 1.3 heads are self-adjusting the function drops normal person changes quickly in systematic circulation blood pressure when, the head can be passed adjust independently functional generation protects effect, make change of cerebral blood flow not big.

SAS诱发CVD的病理生理机制。1血压升高睡眠中呼吸暂停可导致机体缺氧，交感神经过度兴奋，血浆儿茶酚胺、肾素以及血管内皮素升高，导致血管痉挛；血管舒缩功能紊乱，可使血管平滑肌发生重构和肥厚，全身血管阻力增加；慢性缺氧时肾素—血管紧张素系统被激活，导致血压升高。1.2低氧血症OSAS患者气道阻力增加，造成气流中断、呼吸暂停，同时机体逐渐适应低氧环境，呼吸中枢对低氧和高碳酸血症敏感性下降，呼吸暂停次数增加，进一步加重机体缺氧。1.3脑自动调节功能下降正常人在体循环血压快速变化时，脑可通过自主调节功能产生保护效应，使脑血流量变化不大。

Function of limbs plant nerve is mixed mussily nutrient obstacle is relatively apparent; Hemal easy shrinks change, not secrete sweat, thenar ulcer, without painful sex paronychia.

肢体植物神经功能紊乱和营养障碍较为明显；血管舒缩改变，不泌汗，足底溃疡，无痛性甲沟炎。

"Compared with nonuse of hormone therapy, oral conjugated equine estrogen therapy increases the risk of venous thrombosis dose-dependently, esterified estrogen does not influence venous thrombosis risk, and the use of any estrogen in combination with medroxyprogesterone acetate increases risk as well," the authors write."If replicated, these findings for venous thrombosis may have implications for the choice of hormone in treating menopause-related vasomotor symptoms in perimenopausal and postmenopausal women."

Smith博士同时指出，相较於非荷尔蒙使用者，口服结合性雌激素不论剂量高低都会提高静脉栓塞的风险，脂化雌激素对静脉栓塞并不会造成影响；任何雌激素，只要伴随medroxyprogesterone acetate，都会提高静脉栓塞的风险；如果本项试验适用，就可以选择正确的荷尔蒙疗法，以治疗更年期及停经期妇女的血管舒缩症状。

Findings suggest that rostral neuro-structures do exert tonic influence on medulla vasomotor functions.

以上发现显示：吻端的神经结构对於延脑管制血管舒缩的功能，会发挥紧张性的影响。

Among them,therole of Vasomotor dysfunction and imbalanceof vascular tension factors are important in the happening and development of ASO,and that has become a focal point of investigation ."WenMaiTong"is an effective formula to treat early ASO, and the total effective rate is 98.1% in clinic.

国内外学者对ASO的发病机理已做了深入的研究，其中血管舒缩功能障碍及血管张力因素分泌的不平衡在ASO的发生发展中起着重要的作用，正日益成为人们研究的焦点之一。

Changes in blood flow are secondary to a relaxation of small arteries and arterioles, whilst changes in microvascular permeability, leading to inflammatory edema formation and cell accumulation, are mediated via changes that occur at the postcapillary venule level.

血管活性肽分子及其相关肽段可以内分泌的方式发挥循环激素的作用，还可以旁、自分泌的方式，通过其靶细胞表面的G蛋白偶联受体，在血管局部发挥其调节血管舒缩、细胞增殖迁移和分泌等复杂的生物学作用。

The present invention is directed to substituted propylamine derivatives of formula I or a pharmaceutically acceptable salt thereof, compositions containing these derivatives, and methods of their use for the prevention and treatment of conditions ameliorated by monoamine reuptake including, inter alia, vasomotor symptoms, sexual dysfunction, gastrointestinal and genitourinary disorders, chronic fatigue syndrome, fibromylagia syndrome, nervous system disorders, and combinations thereof, particularly those conditions selected from the group consisting of major depressive disorder, vasomotor symptoms, stress and urge urinary incontinence, fibromyalgia, pain, diabetic neuropathy, and combinations thereof.

本发明涉及式I的取代丙胺衍生物或其医药学上可接受的盐、含有这些衍生物的组合物、和其用于预防和治疗通过单胺再摄取改善的病状的使用方法，所述病状尤其包括血管舒缩症状、性功能障碍、胃肠道和泌尿生殖道病症、慢性疲劳综合症、纤维肌痛综合症、神经系统病症和其组合，特别是那些选自由严重抑郁症、血管舒缩症状、压力性和急迫性尿失禁、纤维肌痛、疼痛、糖尿病性神经病变和其组合组成的群组的病状。

The activation of endothelial cell caused by TNF-α has detrimental effects on the vasculature. TNF-α can induce the increased apoptosis of gravid trophocyte. TNF-α has been showing up-regulate the vasoconstriction factors such as endothelin and down-regulate the vascular relaxing factors such as NO on the contrary.

肿瘤坏死因子α作为炎性分子，激活血管内皮细胞、间接影响血管舒缩功能，通过各种机制诱导胎盘滋养细胞凋亡增加，增加血管收缩因子并减少血管舒张因子的生成和释放，影响与脂类代谢相关的细胞因子。

Endothelium-derived nitric oxide plays an important role in the regulation of vasomotion and the balance between thrombosis and thrombolysis.

血管内皮细胞产生的一氧化氮(nitric oxide，NO)在调节血管舒缩、维持凝血—溶栓平衡方面扮演着重要的角色。

It is found to relate to atherosclerosis, increasing tension of coronary artery, coronary vasospasm, coronary thromboses and vascular restenosis after percutaneous transluminal coronary angioplasty that endothelium reduce generation and re lesae of EDRF/NO.

随着内皮分泌功能的发现，人们逐渐认识到内皮不仅仅是具有单纯弥散屏障作用的细胞成份，它还有：1、调节血管舒缩；2、防止血栓形成；3、大范围的激素调节；4、促使或抑制内皮本身和血管平滑肌细胞的增生；5、调节儿茶酚胺、血小板产物的代谢和失活等作用。

Do you know, i need you to come back

你知道吗，我需要你回来

Yang yinshu、Wang xiangsheng、Li decang,The first discovery of haemaphysalis conicinna.

1〕 杨银书，王祥生，李德昌。安徽省首次发现嗜群血蜱。