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The topical application of tanshinone IIA at one μg/ml and five μg/ml caused significant dose-related vasodilation, indicated by the increased agent/control ratio of arteriolar diameters from 1.0 to 1.25±0.08 and 1.57±0.11, respectively, in the hamster cheek pouch.

研究人员同时发现丹参酮IIA通过增加内皮表达一氧化氮合酶扩张金仓鼠颊囊小动脉,局部应用1μg/ml和5μg/ml的丹参酮IIA可引起血管舒张,具有明显剂量相关性——处理组/对照组金仓鼠颊囊小动脉内径分别由1.0扩张到1.25±0.08 和 1.57±0.11。

The topical application of tanshinone IIA at one μg/ml and fie μg/ml caused significant dose-related asodilation, indicated by the increased agent/control ratio of arteriolar diameters from 1.0 to 1.25±0.08 and 1.57±0.11, respectiely, in the hamster cheek pouch.

研究人员同时发现丹参酮IIA通过增加内皮表达一氧化氮合酶扩张金仓鼠颊囊小动脉,局部应用1μg/ml和5μg/ml的丹参酮IIA可引起血管舒张,具有明显剂量相关性——处理组/对照组金仓鼠颊囊小动脉内径分别由1.0扩张到1.25±0.08 和 1.57±0.11。

Conclusions— In HCM the asodilator response is reduced, particularly in the endocardium, and in proportion to the magnitude of hypertrophy.

结论——对于HCM患者,血管舒张反应减退,尤其是在心内膜,而且这与心肌肥厚的程度成比例。

The aim of the present study was to establish a non invasive technique of transdermal drug iontophoresis to assess cutaneous endothelial function in hypertensive patients.

目的 内皮细胞功能是目前研究的热点,本研究用离子电渗透法比较了高血压患者和正常血压者内皮细胞功能和血管舒张功能。

These substances are strong vasodilator agent, can reduce peripheral vascular resistance and coronary heart against the human body catecholamine pressor substances, such as the role, but also to promote the excretion of sodium, so that blood pressure dropped.

这些物质均为较强的血管舒张剂,能减少外周血管和心脏冠状动脉的阻力,对抗人体内儿茶酚胺等升压物质的作用,又能促进钠盐的排泄,从而使血压下降。

The hypothermia and vasodilatory effects of chlorpyrifos were blocked by administration of scopolamine,but not by methylscopolamine.

东莨菪碱可以阻断CHP的降温作用和血管舒张效应,但甲基东莨菪碱对其作用无明显影响。

Results: The total saponins of Achyranthes Bidentata Blume not only had significantly inhibitive effects on NE-induced vasoconstriction, but also had direct relaxation effect on vascular smooth muscle.

结果:怀牛膝总皂苷不仅对NE引起的血管收缩有显著的抑制作用,而且还有直接舒张血管平滑肌的作用。

The NO content and the NOS activity were down in the PIH pregnant women placenta.This showed that the ghrelin regulated the VEGF and influenced the the NO down.And the placenta angiospasm,blood pressure highten, and the PIH were caused also by this. The ghrelin,VEGF,Flt-1,NO and NOS were detected by the SP-immunochemistry, RQ-PCR,cell culture in vitro,ASODN and nitrate reductase in the normal pregnancy,PIH placenta and the cultured HUVEC antisense blocking ghrelin in vitro.

结果证实:PIH孕妇胎盘组织中Ghrelin,VEGF、Flt-1蛋白和mRNA水平下降与正常孕妇比较有显著性差异p<0.05提示在PIH发病过程中Ghrelin可能对VEGF,Flt-1蛋白和mRNA的表达具有下调作用,进而影响胎盘血管网的形成和发育;NO含量与NOS活力水平在PIH孕妇胎盘组织中下降,提示Ghrelin可能通过下调VEGF的表达进一步影响血管舒张因子NO水平下降,进而引起胎盘血管痉挛,血压升高,最终导致PIH的发生。

Methods The plasma levels of CGRP in 59 cases of normal pregnant women, 57 cases of PIH, and 10 cases of nonpregnant women were determined with a sensitive radioimmunoassay.

是由周围血管神经纤维末梢和甲状腺C细胞合成、分泌的,广泛分布在神经组织以及某些器官中,是体内较强的血管舒张物质,参与血压动态平衡的维持及器官血流的调节[2,3]。

Bradykinin is belieed to be the most important mediator of HAE attacks, the authors explain, and bradykinin B2 receptors (BR-2) mediate most physiological actions of kinins, including asodilation.

目前认为缓激肽是遗传性血管水肿发作的最重要的介导物,作者解释说,而缓激肽B2受体(BR-2)介导了包括血管舒张等激肽的大部分生理活动。

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