血管舒张的

Adrenoceptor antagonization did not change the tension of femoral artery, but abolished the ISO induced vasorelaxation of coronary artery.

1受体阻断不影响ISO产生的股动脉血管舒张，但消除了冠状动脉的血管舒张。

RESULTS Endothelium removal, NOS inhibition,β2 adrenoceptor antagonization did not change the vasorelaxation induced by ISO in coronary artery, however, abolished the vasorelaxation in femoral artery.

结果 无论冠状动脉或股动脉ISO均产生浓度依赖的血管舒张。去除内皮， NOS抑制，β2受体阻断不影响ISO产生的冠状动脉血管舒张，而完全消除了股动脉的血管舒张。

The first part consists of three experiments:(1) The rings were incubated in KH, 20, 50 mmol/L 〓 for 1 house, relaxation in response to the EDHF stimuli A23187 in 30nmol/L U46619-induced preconrtaction in the presence of 7 μ mol/L indomethacin, a cyclooxygenase inhibitor, 300μmol/L LNNA, a nitric oxide biosyhnthesis inhibitor, and 1mmol/L tetraethylammonium , a 〓 blocker, or 3 μmol/L glibenclamide , a 〓 blocker, was compared with the control;(2) After the arteries were incubated in KH, UW solution or HTK solution at 4℃ for 4 hours, endothelium-derived relaxation (percentage of 30nmol/L U46619 precontraction) was induced by A23187 in the present of 7 μmol/L indomethacir and 300μmol/L LNNA;(3) After incubation with KH, UW solution and STH (either at 37℃ in oxygenated organ chamber or at 4℃ in a refrigerator for 4 hours), endothelium-derived relaxation (percentage of 30nmol/L U46619 precontraction) was induced by A23187 in the present of 7 μ mol/L indomethacin and 300 μmol/L LNNA.

第一部分研究结果：（1）单纯浸泡于KH的冠状动脉A23187能引发66.67％的血管舒张反应，经TEA及20mmol／L、50mmol／L钾离子作用后，血管舒张反应程度显著降低，但经GBM作用后改变不明显；（2）与保存于KH的冠状动脉相比，A23187引发的血管舒张反应程度，保存于UW液的明显下降，保存于HTK液的无明显变化；（3）在37℃条件下，血管环浸泡于STH出现缓慢轻微的舒张反应，浸泡于UW液初期出现短暂收缩反应，但此后主要以舒张为主：在37℃条件下，血管经UW液保存后，U46619引发的收缩反应程度降低；不论在37℃或4℃条件下，A23187引发的血管舒张反应，经UW液保存后明显下降，但用STH保存后变化不明显。

METHODS: The rabbit hindlimb normothermic tourniquet ischemia model was employed. The tendon on the dorsum of the foot was exposed for observation of microvessels. The responses of arterioles on tendon surface to topical application of 10(-6) mol/L noradrenaline, 10(-6) mol/l acetylcholine (an endothelium-dependent vasodilator) and 10(-4) mol/L nitroglycerin (an endothelium-independent vasodilator) were observed at the period of ischemia and following 30 minutes of reperfusion after 2 hours and 5 hours of ischemia by use of intravital microscopy.

应用兔后肢止血带常温缺血模型及足背肌腱表面微循环观察法，观察肢体缺血 2小时及 5小时再灌注后微动脉对局部滴注血管收缩剂 [去甲肾上腺素(10 - 6 mol/ L ) ]、内皮依赖性血管舒张剂 [乙酰胆碱(10 - 6 mol/ L ) ]及内皮非依赖性血管舒张剂 [硝酸甘油(10 - 4 mol/ L) ]的反应性变化。

Background— It has been proposed that under hypoxic conditions, nitrite may release nitric oxide, which causes potent vasodilation.

背景——过去已经提出，在缺氧条件下，亚硝酸盐会释放引起有效血管舒张的一氧化氮。

The activation of endothelial cell caused by TNF-α has detrimental effects on the vasculature. TNF-α can induce the increased apoptosis of gravid trophocyte. TNF-α has been showing up-regulate the vasoconstriction factors such as endothelin and down-regulate the vascular relaxing factors such as NO on the contrary.

肿瘤坏死因子α作为炎性分子，激活血管内皮细胞、间接影响血管舒缩功能，通过各种机制诱导胎盘滋养细胞凋亡增加，增加血管收缩因子并减少血管舒张因子的生成和释放，影响与脂类代谢相关的细胞因子。

The purpose of this study was to compare the vasodilating effects of angiotensin-(1-7) [Ang-(1-7)] on the different vessels and to clarify its mechanisms by using relaxing responses of preconstricted vascular rings.

实验采用兔外周动脉离体标本，在预收缩血管后，用血管紧张素[angiotensin--(1--7)，Ang--(1--7)]舒张血管，比较Ang--(1--7)对外周各血管床的舒张效应并分析其产生机制。

These results indicate that apelin-13 relaxes the thoracic aorta in the two groups and the response of vasodilatation is enhanced in the rat thoracic aortas from the 2K1C hypertension group. It may be an important protecting factor and play an important role in the protection of blood vessel.

Apelin-13具有显著的舒张主动脉的作用，并且对高血压大鼠血管环的舒张作用更强，提示Apelin-13在血管的保护作用中扮演了重要角色。

Our results indicated that (1)SO_2 derivatives could dose-dependently relax the isolated aorta rings with or without endothelium precontracted by NE, no difference was found for the rings with and without endothelium;(2)Levels of cAMP and 6-Keto(PGI_2) in isolated aortic rings were increased by SO_2 derivatives in a dose-dependent way, which were independent of endothelium;(3)SO_2 derivatives decreased cGMP levels in the rings, but not significantly; The decrease of cGMP levels was also independent of endothelium;(4)No changes of TXB_2 in rings with or without endothelium were observed;(5)Whether presence or absence of endothelium, cAMP/cGMP and 6-Keto/TXB_2 ratios were increased significantly.

结果：①SO_2衍生物对去甲肾上腺素预收缩的内皮完整和去除内皮的大鼠胸主动脉血管环均呈浓度依赖性舒张作用，且其张力变化在内皮完整与去内皮的血管环之间无显著性差异；②SO_2衍生物可引起血管组织中cAMP、6-Keto(即PGI_2)含量剂量依赖性增加，其增加程度与内皮无关；③SO_2衍生物对血管环cGMP含量呈降低趋势但在统计学上无显著意义，且对去除内皮血管无显著影响；④SO_2衍生物对去内皮或内皮完整血管环的TXB_2含量均无明显影响；⑤无论是否去除内皮，SO_2衍生物均可引起cAMP／cGMP和6-Keto／TXB_2比值显著升高。

Abstract］ Objective To assess the endothelium-dependent relaxation in patients with essential hypertension or hypertension smokers by color Doppler flow imaging.Methods With intermittent ultrasound imaging and power Doppler imaging,we measured endothelium-dependent relaxing function in 72 subjects 24 of whom with essential hypertension,24 of whom with both hypertension and smokingand the others as normal control.We measured the diameter of the superficial femoral and brachial arteries at rest,during reactive hyperaemia,re-test and after sublingual glyceryl trinitrate for evaluating the endothelium-independent dilatation in subjects.The level of plasma NO,ET,PGI2,and TXB2 were determined.

摘要］ 目的探讨原发性高血压及高血压合并吸烟患者血管内皮依赖性舒张功能的改变方法采用彩色普勒高频超声的间歇成像和能量多普勒成像，对24例原发性高血压患者、24例高血压合并吸烟患者及24例正常血压无吸烟史者的血管内皮依赖性舒张功能，包括静息时血管内径、增加流量引起的血管舒张、硝酸甘油引起的血管舒张等，以及对血浆氧化氮、内皮素、血栓素B2（TXB2）和列腺环素（PGI2）等血管活性物质进行检测并比较分析。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。