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血管舒张

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Isolated rat pulmonary artery was perfused and the tension of the vessel was measured, the effect of isopropyl 3-(3,4-dihydroxyphenyl)-2-hydroxypropanoate on the pulmonary artery precontracted by noradrenaline and concentration-response curves of 5-hydroxytryptamine(5-HT), endothelin-1(ET-1), U46619 and KCl was also observed.

制备大鼠肺动脉条,采用离体血管灌流方法,观察丹参素异丙酯对去甲肾上腺素预收缩动脉的舒张作用以及对多种血管收缩药量效曲线的影响。

Result: Isopropyl 3-(3,4-dihydroxyphenyl)-2- hydroxypropanoate exerted relaxation effect on the endothelium-intact artery precontracted by NE in a concentration-dependent manner, which was inhibited with denuded endothelium. The right-shift of the concentration-response curves of 5-HT, ET-1, U46619 and KCl.

结果:丹参素异丙酯可浓度依赖性舒张NE预收缩的完整内皮血管,去内皮后该作用明显降低;对5-羟色胺(5-HT)、内皮素(ET-1),U46619和KCl量效曲线均表现浓度依赖性抑制。

ConclusionG-Rb has protective effects on ventricular remodeling through improving systolic and diastolic function of cor sinistrum in ventricular remodeling rats,increasing anti-oxidase activity, reducing the damage of free radicals and vasoactive substance in myocardium and correcting disequilibrium of PGI2/TXA2 in ventricular remodeling etc.

结论G-Rb对大鼠心室重构具有保护作用,可能与其改善心室重构大鼠的左心收缩和舒张功能,增强抗氧化酶活性,减少自由基及缩血管活性物质对心肌的损伤,纠正PGI2/TXA2失衡等机制有关。

The relaxing responses of renal arteries to DA receptor agonists may be related to the change of cAMP content.

DA1受体激动剂对肾血管的舒张反应可能与cAMP生成量的变化有着密切关系。

Until recently, he tells WebMD, scientists thought most of the citrulline was in the watermelon rind.

这种氨基酸可以舒张血管,很像伟哥和其他用来治疗勃起功能不全的药物。

Though arginine is required to make nitric oxide, and nitric oxide is required to dilate blood vessels and have an erection,"that doesn't mean eating something that is rich in citrulline will make enough arginine that it will lead to better penile erections," Goldstein says.

尽管生成一氧化氮需要精氨酸,而舒张血管跟勃起需要一氧化氮,Goldstein说:&那不意味着吃点富含瓜氨酸的东西就会产生总够的精氨酸,从而导致阴茎更好的勃起&。

The diameter in brachial artery in responding to reactive hyperaemia was improved greatly than before treatment. After 6 months of treatment, SBP and DBP were all cut down obviously than before treatment.

贝那普利治疗2型糖尿病并发高血压患者在降低BP的同时能有效地改善血管内皮依赖性舒张功能,且使血浆Tm和vW因子水平降低,NO水平升高。

Methods The changes of contents of AGEs in plasma and the abdominal aorta and changes of VSMC of the abdominal aorta were investigated with methods of fluorospectrophotometry, immunohistochemistry, computer image analysis and transmission electron microscopy on streptozotocin-induced diabetic rats. Results From the fourth week, in diabetic rats, the contents of AGEs in plasma and the abdominal aorta increased, the relative area of α-SM-actin in the abdominal aorta decreased, the density of nucleus of VSMC increased, and mitochondria and rough endoplasmic reticules in VSMC increased.

后者在早期主要是血管平滑肌细胞(vascular smooth muscle cell, VSMC)和胶原纤维增多,弹性纤维减少,动脉增厚等,引起动脉的顺应性降低,舒张功能减弱[1~3];晚期主要表现为动脉粥样硬化和动脉硬化,其中以VSMC的增生和迁移较为突出,其表型也由收缩型转化为合成型[4,5]。

This leads to subtle changes in the autonomic nervous system, which controls the contraction and relaxation of these vessels.

这使得控制血管收缩和舒张的自主神经系统发生了微妙的变化。

This leads to subtle changes in the autonomic nervous system, which controls the contraction and relaxation of these vessels.

这导致控制这些血管收缩和舒张的自主神经系统发生微妙变化。

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