血管纤维瘤

Abstract］ objective to study the pathological features and histopathological type and differential diagnosis of hepatic focal nodular hyperplasia.methods the clinicopathological characteristics of 40 cases of fnh were studied.all were evaluted by use of paraffin embedded sections and he staining before light microcope observation.results there were 28 females and 12 males fnh patients whose age were from 16 to 62 years（median 41.3）,all alpha-fetoprotein was negative and had no hepatitis history.25 cases were classic type showed characteristic central stellate fibrotic scar,composed of fibrous connestive tissue and tortuous blood vessels.8 cases were telangiectic type,the left were mixed type and adenomatoid type.conclusion fnh is a reactive proliferation of hepatic cells to local blood vessel anomalies,it is not realy a tumor.its differential diagnosis includes hepatic adenomatous hyperplasia nodule,hepatic anaplasia nodular hyperplasia,fibrolamellar hepatocellular carcinoma and hepatocellular adenoma.

目的 探讨肝局灶性结节性增生的病理形态特点、组织分型及鉴别诊断。方法分析40例肝局灶性结节性增生的临床资料，并采用石蜡包埋he染色光镜下观察其组织学特点。结果 40例肝局灶性结节性增生患者中，女28例，男12例，年龄18~62岁，平均年龄41.3岁，所有病例术前均无肝炎病史，甲胎蛋白阴性，组织学上25例为经典型，有特征性的中央纤维瘢痕，由纤维结缔组织及扭曲血管组成。8例为毛细血管扩张型，其余为混合型及腺瘤样增生型。结论肝结节性增生是一种肝细胞对局部血管的异常反应性增生，并非真性肿瘤，主要与肝腺瘤样增生性结节、肝间变性结节状增生、肝纤维板层癌及肝细胞腺瘤鉴别。

Types include hemangiosarcoma, fibrosarcoma, and fibroma.

种类包括血管肉瘤，纤维肉瘤及纤维瘤。

Specifically, kaposiform hemangioendothelioma must be differentiated from infantile fibrosarcoma.

尤其是卡波西样血管内皮瘤，需要与婴儿手部纤维肉瘤相鉴别。

Objective To investigate the feasibility of endoscopic nasal surgery for nasopharyngeal angiofibroma to avoid complications of routine surgeries.Methods Retrospective analysis was performed for six patients'clinical records from June2002to June2004.Endoscopic nasal surgery and other techniques such as CT,MRI,digital substract angiography,Controlled-hypotention anesthesia and preoperative feeding artery embolism had been used.Results No complication had occurred.

目的 避免常规手术的并发症，探讨经鼻内镜引导下鼻咽纤维血管瘤切除术的可行性方法回顾性分析从2002年6月～2004年6月收治的6例经鼻内镜手术治疗的鼻咽纤维血管瘤患者的临床资料，术均行CT或MRI检查，了解瘤体小及部位，行字减影血管造影了解瘤体血供，术前采用供血动脉栓塞，术中采用控制性低血压技术。

Nine patients were female and one male (ages 31-77, average 52 years). Six patients presented parenchymal vascular lesions (1 angiosarcoma, 1 atypical hemangioma, 3 perilobular hemangiomas, 1 cavernous hemangioma) measuring 0.5-6 cm in the greatest diameter. Two lesions were accidental findings in lumpectomy specimens excised for fibrocystic disease with microcalcifications. Four patients presented non-parenchymal vascular lesions: three cavermous hemangiomas and one angiolipoma measuring 1-6 cm in diameter.

女性9例，男性1例（年龄31-77岁，平均52岁）。6例表现为实质血管性病变（血管肉瘤1例，不典型血管瘤1例，小叶周围血管瘤3例，海绵状血管瘤1例），大小0.5-6cm.2例因乳腺纤维囊型病变伴微钙化在切除的标本上偶然发现。4例呈非实质性的血管病变，其中海绵状血管瘤3例（1例为男性），1例为血管脂肪瘤，最大直径为1.6cm。

Most endothelial cells fell off, elastic fibre autolyze; the number of SMC decreased, some SMC nucleus contracted completely or depressed, typical apoptosis body were seen in later stage, muscle silk autolyzed and disappeared mostly; in outer layer saw much collagenic fiber, arranged unorderly; inflammation cells were seen in the aneurysm wall(hypertrophy cell et al.).

多数瘤壁的内皮细胞溶解脱落，不连续，弹力纤维自溶；动脉瘤血管壁均可见SMC明显减少，较多SMC染色质边聚、固缩，部分SMC核全部固缩或出现不规则凹陷，SMC核胞浆或胞核部分出现脱落或裂解成碎片，晚期可见典型的凋亡小体出现，肌丝大都自溶消失：外膜可见大量的胶原纤维，排列较紊乱；瘤壁还可见炎性细胞浸润。

B, Color Doppler scan of a Desmoid tumor in a previous scar revealing some vascularity in the lesion.

图16，A，以前疤痕处的硬纤维瘤。B，彩色多普勒扫描以前瘢痕处的硬纤维瘤病变处显示一些血管供应。

Results; MRI showed such components as fat,fibre,and liquid in teratoma,and large vessels in fibrolipomatous angioma;lytic bone destruction in giant cell tumor...

结果：畸胎瘤含脂肪、纤维和液体等成分；纤维脂肪血管瘤含有粗大血管；骨巨细胞瘤呈溶骨性破坏，1例在T2WI有液-液平面；神经源性肿瘤通过骶孔与骶管内病变相连，神经节母细胞瘤和神经外胚层瘤破坏骶孔；9例脊索瘤在T2WI有条状低信号纤维结构和高信号粘液基质；未分化癌和淋巴瘤T1WI呈略低信号，T2WI呈略高和较高信号；19例转移瘤有多处骨骼破坏，5例只有骶椎侵犯。

MethodsThe transplanted tumor model of the mouse S180 sarcoma was established.Fifty mice were randomly divided into five groups,the control group,the CTX group,the Gecko group.They were treated respectively with oral administration of saline,and intraperitoneal injection of CTX 100 mg/kg only one time,oral administration of Gecko in doses of 13.5,9,4.5 g/kg,one time a day.After 14 days,the anti-tumor activity was evaluated by tumor tissue weighing. The impact on immune organ was detected by accounting thymus index, spleen index and the number of peritoneal macrophage which phagocytose chicken red blood cells.The protein express of vascular endothelin growth factor and basic fibroblast growth factor were detected by SABC immunohistochemistry.

方法建立移植瘤小鼠S180肉瘤模型，将50只雌鼠随机分为对照组、环磷酰胺组、壁虎高组、中组、低组共5组，分别给于生理盐水灌胃1次/d，CTX（100 mg/kg）腹腔注射1次，壁虎高、中、低组（13.5，9，4.5 g/kg），每天灌胃1次。14 d后，称取荷瘤小鼠瘤重、胸腺重、脾脏重，计算抑瘤率、胸腺指数、脾脏指数，观察腹腔巨噬细胞吞噬鸡血红细胞实验指标；用SABC免疫组化法检测血管内皮生长因子、碱性成纤维细胞生长因子的蛋白表达，TUNEL方法检测细胞凋亡率。

Results The BMC surrounding tumor mass and strands showed multi-layered or dissolution, pseudopodia were seen extended from tumor cells, and contained numerous microvesicles.

瘤细胞伸出伪足样突起，且胞浆内含大量微泡，该处基膜消失，胶原原纤维溶解，肿瘤细胞围绕血管部位的血管基膜增厚，纤维组织增生。

Breath, muscle contraction of the buttocks; arch body, as far as possible to hold his head, right leg straight towards the ceiling (peg-leg knee in order to avoid muscle tension).

呼气，收缩臀部肌肉；拱起身体，尽量抬起头来，右腿伸直朝向天花板（膝微屈，以避免肌肉紧张）。

The cost of moving grain food products was unchanged from May, but year over year are up 8%.

粮食产品的运输费用与5月份相比没有变化，但却比去年同期高8％。