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Objective To investigate the effects of angiotensin Ⅱ receptors antagonist on the LPS-induced acute lung injury.

目的 研究血管紧张素Ⅱ受体拮抗剂对大鼠内毒素性急性肺损伤的保护作用。

Objective To investigate the inhibition of rapamycin in angiotensin Ⅱ-induced vascular endothelial cell proliferation.

目的 免疫抑制剂雷帕霉素对血管紧张素Ⅱ诱导的脐静脉内皮细胞抑制作用机制。

Objective To investigate the expression and pathobiological implications of angiotensin Ⅱ type 1 receptor in development of myocardial fibrosis of rats.

目的 探讨血管紧张素Ⅱl型受体在心肌纤维化中的表达及其意义。

Abstract] AIM: To investigate the effects of angiotensin II receptor antagonist on remodeling of renal arterioles in hypertension.

摘 要]目的:研究血管紧张素II受体拮抗剂对高血压肾小动脉重建的影响。

Methods 48 patients were given valsartan 80 mg/d for 12 weeks, the heart function parameter, the amount of rennin, angiotonin and aldosterone were tested before and after therapy.

48例chf患者均口服缬沙坦,80 mg/d,疗程12周,比较治疗前后心功能指标变化,并检测治疗前后肾素、血管紧张素及醛固酮的含量。

All patients were treated for 20 days.Before treatment and after treatment, 24 hour urine proteinuria,urine micro-albumin , urine IgG,urine α1-microglobulin,urine red blood cell number ,blood urea nitrogen,serum creatinine,endogenous creatinine clearance rate plasma rennin and angiotoninⅡconcentration were meatrued.

观察治疗前后血浆肾素、血管紧张素、24h尿蛋白定量、尿微量白蛋白、尿免疫球蛋白G、尿α1-微球蛋白(尿α1-M)、尿红细胞数、血尿素氮、血清肌酐及内生肌酐清除率Ccr等指标的变化。

All patientswere treated for 20 days. Before treatment and after treatment, 24 hour urineproteinuria, urine micro-albumin, urine IgG, urineα_1-microglobulin, urine redblood cell number ,blood urea nitrogen,serum creatinine,endogenouscreatinine clearance rate plasma rennin and angiotoninⅡconcentration weremeatrued.

观察治疗前后血浆肾素、血管紧张素、24h尿蛋白定量、尿微量白蛋白、尿免疫球蛋白G、尿α_1-微球蛋白(尿α_1-M)、尿红细胞数、血尿素氮、血清肌酐及内生肌酐清除率Ccr等指标的变化。

Armando et al9 showed that intact female mice have higher AT2R expression in the kidney compared with ovariectomized females.

Armando等19人研究显示正常的成年雌鼠比卵巢切除后雌鼠肾脏血管紧张素II受体表达水平高。

This increase in angiotensin II result s in a dramatically increased renal tubular avidity for Na+.

血管紧张素Ⅱ增多导致肾小管对Na+的亲和力大大增强。

This increase in angiotensin II results in a dramatically increased renal tubular avidity for Na+.

血管紧张素Ⅱ增多导致肾小管对Na+的亲和力大大增强。

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