血管紧张的

Objective: Rennin angiotensin aldosterone system plays a crucial role in the initiation and development of cardiac remodeling. Angiotensin II has multiple physiological effects on the cardiovascular system.

目的：肾素-血管紧张素-醛固酮系统过度活跃在多种心血管疾病的发生、发展中发挥重要作用，血管紧张素Ⅱ作为重要的生长促进因子，对多种组织、细胞的生长具有促进作用，是刺激心肌肥厚的主要因素之一。

This enzyme catalyses the conversion of angiotensin I to angiotensin II in the blood plasma and endothelia and prevents the breakdown of bradykinin.

这种酶催化的血管紧张素一血管紧张素血液中的血浆和内皮二，防止故障的激肽转换。

Activities of chymase and ACE were tested by radioimmunological method. Expressions of phosphoric extracellular signal regulated kinase 1/2 (p-ERK1/2) in hearts were measured by western blot. Results: As compared to the control group levels of GSP, myocardial enzymes and myocardial Ang Ⅱ were much lower in those of APS group.

心肌组织的血管紧张素Ⅱ含量；RT-PCR法检测心肌糜酶和血管紧张素转换酶 mRNA表达；放免法检测chymase和ACE的活性；免疫蛋白印迹法检测心肌磷酸化的细胞外信号调节激酶1/2(p-ERK1/2)含量。

Fie years after initiation of treatment, 79% patients were still on renin-angiotensin inhibitors, 65% on -blockers, 56% on spironolactone, and 83% on statins. Notably, multiple drug treatment and increased seerity of heart failure was associated with persistence of treatment. Nonpersistence with renin-angiotensin inhibitors,-blockers, and statins was associated with increased mortality with hazard ratios for death of 1.37 (95% CI, 1.31 to 1.42), 1.25 (95% CI, 1.19 to 1.32), 1.88 (95% CI, 1.67 to 2.12), respectiely.

开始治疗5年后，有79％病人继续使用肾素血管紧张素抑制剂，65％用阻滞剂，56％用安体舒通，83％使用他汀类，值得注意的是，联合用药和心衰的加重同坚持治疗相关，无法坚持使用肾素血管紧张素抑制剂，阻滞剂，安体舒通，他汀类药物的病人同增加的死亡率相关，其死亡危险比分别为1.37 (95%可信区间， 1.31 － 1.42)， 1.25 (95%可信区间， 1.19 － 1.32)， 1.88 (95%可信区间， 1.67 － 2.12)，。

Importantly, activation of the renin-angiotensin system was noted in the triply n/i/eNOS-/- mice, and long-term oral treatment with an angiotensin II type 1 receptor blocker significantly suppressed coronary arteriosclerotic lesion formation and the occurrence of spontaneous myocardial infarction and improved the prognosis of those mice, along with ameliorating the metabolic abnormalities.

重要的一点是我们注重到三重缺陷小鼠的肾素-血管紧张素系统激活，而长期口服血管紧张素II 1型受体阻滞剂可以显著抑制冠状动脉硬化损伤的形成以及自发性心肌梗死的发生，并改善这些小鼠的预后，同时也能改善代谢异常情况。

Endothelin-1 (ET-1) is a potent vasoconstrictive peptide that was isolated initially from the conditioned medium of cultured endothelial cells. It is a pathogenic mediator with a number of deleterious effects, including vasoconstriction, fibrosis, vascular hypertrophy,and inflammation.Atrial natriuretic peptide, angiotensin II and nitric oxide also takes an important role in cardiovascular system.

内皮素-1(endothelia-1，ET-1)是一种由内皮细胞合成和分泌的、具有强烈收缩血管作用和促进细胞增生的血管活性多肽，心钠素(atrialnatriuretic peptide，ANP)、血管紧张素Ⅱ(angiotensin Ⅱ，AⅡ)、NO等在心血管系统功能的调节中也起着重要作用。

Aim: To study the effects of angiotensin receptor antaganist-valsartan on vascular hypertrophy、vasomotion function and aorta vascular smooth muscle cell EGF precursor mRNA expression in spontaneously hypertensive rats.

目的：本文探讨血管紧张素受体拮抗剂-缬沙坦对自发性高血压大鼠血管结构、功能以及主动脉血管平滑肌表皮生长因子前体 mRNA表达的影响。

Objective: The purpose of this study is to investigate the relationship between the insertion/deletion polymorphism of the angiotensin- concerting enzyme gene and congenital heat disease and to ques the predisposing gene of congenital heart disease by analyzing the polymorphism of the ACE gene of the patients of congenital heart disease. So that we can intervene earlier and reduce the incidence of congenital heart disease.

目的 通过对先天性心脏病患儿血管紧张与转换酶基因多态性的分析，探讨血管紧张素转换酶基因插入/缺失多态性与先天性心脏病的关系，寻找与先天性心脏病发病有关的易感基因，以便及早进行干预，减少先天性心脏病的发病率。

These results are consistent with the hypothesis that sodium depletion increases circulating angiotensin levels which lead to a down-regulation of the angiotensin receptor located on adrenergic nerve varicosities.

这些结果是与下述假说相一致的，即钠耗竭增加循环中血管紧张素的含量，由此导致位于肾上腺素能神经膨体上的血管紧张素受体减少。

objective to observe the protective effect of qiliqiangxin capsule in rabbit heart ventricle reconstitution of chronic heart failure.methods using the method of giving rabbit abdomen aorta half ligations to build the chronic heart failure model to observe qiliqiangxin capsule the effect to blood flow mechanics index,room wall thickness,heart exponent and heart ventricle reconstitution biochemistry index.results qiliqiangxin capsule could reduce effectively bp,lvsp,lvedp,t wave,improve room wall thickness and heart exponent,reduce angii and alt,all the paramenters ahd notable difference,composed to those of model group (p＜0.05,p＜0.01).conclusion qiliqiangxin capsule can improve the blood flow mechanics change of chronic heart failure rabbit,which has notable inhibitory action on heart ventricle reconstitution which originate from chronic heart failure.inhibition of ang ii,alt of immune nerve endocrine system may be a mechanism of qiliqiangxin capsule.

观察血流动力学、标志心室重构的室壁厚度及心脏指数及肾素―血管紧张素―醛固酮系统相关生化指标的变化。结果芪苈强心胶囊可有效降低血压、左室压、左室末期舒张压、t波，改善室壁厚度和心脏指数，降低血清血管紧张素ii及醛固酮水平，与模型组比较均有显著性差异(p＜0.05，p＜0.01)。结论芪苈强心胶囊可改善慢性心力衰竭兔血流动力学的变化，对慢性心力衰竭引起的心室重构具有显著抑制作用，其机制可能与该药发挥抑制神经内分泌免疫系统rass中angii、ald的水平有关。

Plunder melds and run with this jewel!

掠夺melds和运行与此宝石！

My dream is to be a crazy growing tree and extend at the edge between the city and the forest.

此刻，也许正是在通往天国的路上，我体验着这白色的晕旋。