血管狭窄

"For patients with discrete lesions in saphenous vein bypass grafts, the use of DES reduces short-term angiographic restenosis," said Sheldon Goldberg, MD, of Hahnemann University Hospital, Philadelphia."These results cannot be extrapolated to patients with larger grafts, restenotic lesions total occlusions."

菲律宾Hahnemann大学医院的Sheldon Goldberg说，"对局限的大隐静脉桥血管病变患者DES 可以显著降低造影再狭窄，这一结果不能推广到较大移植桥血管、再狭窄或完全闭塞病变。"

Sex of arteriosclerosis of result lower limbs is out-of-the-way 2 dimension behave disease on supersonic image for pathological changes blood-vessel inside in film is shown irregular add thick, local show strong echo spot, and to hemal antrum inside protuberant, hemal antrum internal diameter shows irregular stricture, pathological changes paragraph solid sex is low it is thus clear that inside hemal antrum echo smooth group fills up; color much general straps blood stream to show resemble showing to; of blood stream signal is not had inside hemal antrum multilayer helix CTA shows pathological change paragraph hemal area does not have comparative agent, show what side raises artery to take travel and initiative place at the same time.

结果下肢动脉硬化性闭塞症二维超声图像上表现为病变血管内中膜呈不规则增厚，局部呈强回声斑，并向血管腔内突起，血管腔内径呈不规则狭窄，病变段血管腔内可见实性低回声光团充填；彩色多普勒血流显像显示血管腔内无血流信号；多层螺旋CTA显示病变段血管区域无对比剂，同时显示侧支动脉的走行及起始部位。

Accuracy between two groups was calculated byχ~2 test.Calculate the average effective radiation dose of the 30 patients.Results In group A,seventeen patients underwent both DSCT coronary angiography and SCAG,among 255 segments of 17 patients,105 lesion sites of 70 segments were diagnosed stenosis or obstruction,of them,95 lesion sites were confirmed by SCAG.The accuracy of DSCTCA was 90.48%.The agreement of two methods have a high agreement(Kappa =0.853).In group B,13 patients underwent both DSCT coronary angiography and SCAG,among 195 segments of 13 patients,73 lesion sites of 57 segments were diagnosed stenosis or obstruction, of them,65 lesion sites were confirmed by SCAG.The accuracy of DSCTCA was 89.04%.The agreement of two methods have a high agreement(Kappa =0.835). There was no significant difference(χ~2=0.098,p＞0.05) between the accuracy of two groups.The effective radiation dose of 30 patients was 3.67±0.43 mSv.Conclusion Compared with SCAG,prospectively ECG-gated transverse DSCT is a valuable examination to detect and diagnose coronary artery disease with a low dose coronary angiography.The accuracy of the DSCT is approximate to the SCAG.There was no significant difference between the accuracy of two groups.

结果200例患者均成功完成了适应性前瞻性心电门控双源CT冠状动脉血管成像；30例同期行SCAG检查的患者，A组17例：HR≤75 bpm，可评价冠状动脉节段255个，70个冠状动脉节段有105处不同程度的狭窄，95处狭窄程度与金标准SCAG相符，其阳性诊断准确率为90.48%；2种方法的诊断结果得到了较高的一致性(Kappa值=0.853)。B组13例；HR≥91 bpm，可评价冠状动脉节段195个，57个冠状动脉节段有73处不同程度的狭窄，65处狭窄程度与SCAG相符，其阳性诊断准确率为89.04%；2种方法的诊断结果得到了较高的一致性(Kappa值=0.835)。2个心率组间的诊断准确率无明显统计学差异(x~2=0.098，p＞0.05)。30例患者的平均有效辐射剂量为3.67±0.43 mSv结论适应性前瞻性心电门控双源CT冠状动脉成像是一种有效减低辐射剂量的扫描方式，其诊断准确率与金标准SCAG相比得到较高的一致性，且高、低2个心率组间诊断准确率无明显统计学差异。

Sensitivity of 64-slice CTA in diagnosis carotid and vertebral arterious stenosis is respectively 97.70%、93.75%, specialty is respectively 99.51%、99.57%.

CTA显示不同程度狭窄的血管段共115段； DSA显示不同程度狭窄的血管段共108段。64层CTA对颈、椎动脉狭窄总的诊断敏感度分别为97.70%、93.75%，特异度分别为99.51%、99.57%。

Various arterious stenosis diagnosed by CTA were 115 segment, DSA 108 segment. Sensitivity of 64-slice CTA in diagnosis carotid and vertebral arterious stenosis is respectively 97.70%、93.75%, specialty is respectively 99.51%、99.57%.

CTA显示不同程度狭窄的血管段共115段； DSA显示不同程度狭窄的血管段共108段。64层CTA对颈、椎动脉狭窄总的诊断敏感度分别为97.70%、93.75%，特异度分别为99.51%、99.57%。

Objective To study the relationship of endangium proliferation and the expression of metalloproteinases and tissue inhibitors of metalloproteinases after angioplasty of iliac artery in rabbits to investigate the probable mechanism of composite Danshen pill in prevention and treatment of restenosisMethods 30 white male rabbits of Japan （the average body weight was 25～30 kg）were randomly divided into 3 groups:normal control group,model group (intima destroyed by balloon and given hypercholesterol diet),CDP group (intima destroyed by balloon and given hypercholesterol diet plus drug CDP 150 mg/d),10 ones each groupResults The results of iliac artery angiogram and the analysis of pathology:there were lumens stenosis,thinner intima,smaller intima area,in CDP group compared with those in model group,and ratio of intima and tunica media thickness and area among each group (P＜001)Immunohistochemistry analysis:the MMP2,MMP9,TIMP1,TIMP2 in model group significantly increased than those in control group (P＜001)The CDP group had lower MMP2 and MMP9 expression,higher TIMP1 and TIMP2 expression,and increased MMP2/TIMP1,MMP9/TIMP2 than model group (P＜001)The thickening of vascular neointima and stenosis degree of vascular lumen were relevant to MMP2 and MMP9 (r=0896,P＜001)Conclusions MMP and TIMP play the very important role in the restenosis process of arteryCDP could inhibit the thickness of vascular neointima after balloon injury,the probable mechanism of which may be inhibiting collagen formation,smooth muscle immigration and decreasing hyperplasia of intima by interfering expression of MMPs and TIMPs

目的 研究兔髂动脉成形术后血管内膜增生和基质金属蛋白酶及其抑制物表达之间的关系，探讨复方丹参滴丸预防再狭窄的可能机制。方法健康成年二级雄性日本大耳白兔30只，平均体重25～30 kg。随机分为3组：正常对照组10只，模型组10只（球囊内膜剥脱加高胆固醇饮食），治疗组10只（球囊内膜剥脱加高胆固醇饮食以及复方丹参滴丸150 mg/d）。结果兔髂动脉造影、血管病理图像分析检测结果：①复方丹参滴丸组较模型组血管造影示管腔直径狭窄、内膜厚度减少、内膜面积减少、内膜厚度和中膜厚度比、面积比，各组之间有显著性差异(P＜001)。②免疫组化分析：模型组MMP2、MMP9、TIMP1、TIMP2表达均高于对照组（P＜001）；复方丹参滴丸组MMP2、MMP9的表达低于模型组，而TIMP1、TIMP2的表达高于模型组；TIMP1/MMP2、TIMP2/MMP9明显增加，差异有显著性（P＜001）。③内膜的增生以及管腔的狭窄程度与MMP2、MMP9有很好的相关性(r=0896，P＜001)。结论 MMP和TIMP在再狭窄形成中起重要作用；复方丹参滴丸能够明显抑制血管损伤后的内膜增生，可能的机制是通过影响金属蛋白酶MMP2、MMP9及其抑制物TIMP1、TIMP2的表达从而抑制胶原的生成、平滑肌的迁移、增生，而减少内膜的增生。

There were 15 cases of middle cerebral arteries, 5 cases of vertebral arteries, 3 cases of basilar arteries and 2 cases of internal carotid arteries. Among all the branches with stenosis, symptomatic severe stenosis presented in 21 vessels (14 MCA, 3 VA, 2 BA and 2 ICA), nonsymptomatic severe stenosis in 1 vessel and symptomatic middle stenosis in 3 vessels (1 MCA and 2 VA).

其中大脑中动脉15支，椎动脉5支，基底动脉3支和颈内动脉2支。21支血管（MCA 14支，BA 2支，VA 3支和ICA 2支）为症状性重度狭窄、1支为无症状性重度狭窄；3支血管（MCA 1支和VA 2支）为症状性中度狭窄。

Hepatocytes which expressed VEGF positively mainly distributed in fatting areas. While in later periods (8 to I 2wk), the liver tissue inflammatory was light, but diseases in hepatocytes were significant.

乙肝肝细胞的变性坏死等与肝内血管病变导致的肝血供障碍密切相关，肝内血管病变主要有血管炎症、血管阻塞、血管破坏、血管增生及肝窦狭窄、阻塞、扩张和肝窦毛细血管化。

Results: l、The optimal scan parameters for chinese people are flow rate of 3. 0 mL/sec and total injection 125ml. 2、Visibility of coronary arteries and segments: only those proximal and mid segment is image quality sufficient to allow a semiquantitative assessment. 3、Detection of Atherosclerotic Plaque: CT coronary imaging revealed highest sensitivities for the detection of atherosclerotic wall changes the sensitivity of stenoses was 86. 3％. 4、MSCT coronary angiography is easy to prove the entire anatomic structure of coronary and it is an effective technique for evaluating coronary patency. 5、MSCT coronary angiography correctly identified all normal controls and all patients with coronary artery fistula. The anatomic course of the coronary artery fistula was correctly classified. 6、A11 severe lesion could be visualised by

结果：1、不同的扫描技术参数所获得的造影图像质量不同，注射速率3.0ml/s组以及125m1对比剂总量组比较适合国内患者。2、多层螺旋CT冠状动脉造影可显示冠状动脉的主要分支，尤其是冠状动脉的近、中段，显示率在90％以上。3、多层螺旋CT冠状动脉造影对狭窄病变的敏感性为87.3％，能检出冠状动脉造影不易发现的细小斑块，判断狭窄的原因及斑块的特征。4、多层螺旋CT冠状动脉造影可显示搭桥血管的形态、位置及通畅程度，显示桥血管及支架的内腔，安全便捷。5、多层螺旋CT显示冠状动脉畸形准确性高（3/3），多种成像方法可弥补冠状动脉造影显示的不足。6、仿真内窥镜可显示冠状动脉内膜和内腔，显示狭窄斑块的性质。

Arrhythmias included second degree atrioventricular block in 3 patients, paroxysmal ventricular tachycardia in 3 patients and frequent ventricular premature beat in 3 patients. Cardiac syncope occurred in 2 patients with Ⅱ°AVB and in a patient with VT.Significant coronary stenosis related to ischemia occurred in 5 patients, and coronary artery was normal in 1 patient.

结果：9例患者心绞痛发作时除有典型的心电图ST段抬高的变化外，均伴有严重的心律失常，其中二度房室传导阻滞3例、室性心动过速3例、频发室性早搏3例。2例Ⅱ度AVB及1例VT伴发作性晕厥。1例Ⅱ度AVB伴黑矇。6例行冠脉造影提示缺血相关血管狭窄5例；1例冠脉造影结果正常。

However, as the name（read－only memory）implies, CD disks cannot be written onorchanged in any way.

然而，正如其名字所指出的那样，CD盘不能写，也不能用任何方式改变其内容。

Galvanizes steel pallet is mainly export which suits standard packing of European Union, the North America. galvanizes steel pallet is suitable to heavy rack. Pallet surface can design plate type, corrugated and the gap form, satisfies the different requirements.

镀锌钢托盘多用于出口，替代木托盘，免薰蒸，符合欧盟、北美各国对出口货物包装材料的法令要求；喷涂钢托盘适用于重载上货架之用，托盘表面根据需要制作成平板状、波纹状及间隔形式，满足不同的使用要求。