血管炎

Methods The endothelium-dependent dilation function was measured with high-frequency ultrasound in 61 patients with Takayasu arteritis and 36 normal subjects, the diameter of the brachial arteries before and after reactive hyperemia was also measured.

我们经过4年的观察研究发现多发性大动脉炎对血管内皮舒张功能有更直接的影响，EDD%在此病的观测中具有重要的临床意义。1资料与方法1.1研究对象①大动脉炎组：选择已确诊

Of the many clinical symptoms, the frequently seen are seborrheic dermatitis, proliferation of blood vessels around cornea, cheilitis, corners of mouth look wet, white, thicker than usual, black and blue with swelling, nipple hypertrophy or atrophy, and often complicated by scrotal dermatitis.

维生素B2缺乏病临床症状较多，常见的有脂溢性皮炎、角膜周围血管增生、唇炎、口角湿白增厚、青红肿、乳头肥大或萎缩，常并发有阴囊皮炎。

American Atlanta conference edited in September 1992 pancreatitis of serious illness acute definition is: AP companion has local complication (cyst of pancreatic and necrotic, false sex, pancreatic abscess) or the organ fails (function of shock, lung not complete, kidney declines, gastrorrhagia, sow medicinal powder the cruor inside sexual blood-vessel and serious metabolization obstacle), or both holds concurrently.

概要： 急性胰腺炎为临床常见急腹症，是由于胰液和溶蛋白酶漏入到胰腺实质和胰腺四周组织而引起。1963年，法国马赛会议以病理形态学为基础，将AP分为水肿性胰腺炎和出血、坏死性胰腺炎。1992年9月美国亚特兰大会议修订重症急性胰腺炎定义为：AP伴有局部并发症(胰腺坏死、假性囊肿、胰腺脓肿)或器官衰竭(休克、肺功能不全、肾衰、胃出血、播散性血管内凝血和严重的代谢障碍)，或二者兼有。

According to histological characteristics by light microscope, renal vascular lesions were divided into five subgroups: no renal vascular lesion, hyalinosis, arteriosclerosis, celluar infiltration And fibroid necrosis.

根据光镜下血管组织病理学特点，将肾间质血管分为以下五种类型：无血管病变型、透明变性型、动脉硬化型、炎细胞浸润型及纤维素变性坏死型。

2Compared with PN group,following microcirculatory changes were observed in EEN group in vivo status:interlobular artery and vein structures disappeared,the vessel course was distorted and deformed;intralobular vessels were twisted into nidus,there was patchy bleeding around the vessel combined with necrosis;microcirculatory structures of pancreatic island disappeared and pancreatic tissue necrotized;capillary network had bleeding and necrosis.

2活体状态下观测大鼠胰腺微循环情况显示与PN组相比，接受EEN治疗大鼠急性胰腺炎微循环小叶间动、静脉伴行结构消失，血管走行扭曲变形更加明显；小叶内血管扭曲变形成团，血管周围出现斑片状出血，并伴有坏死；胰岛微循环结构消失，组织坏死；毛细血管网大片状出血、坏死。

Consistent findings in lung biopsies of AP patients included endothelialitis of pulmonary vessels, active fibrosis, lymphangitic inflammatory infiltrates rich in plasma cells and histiocytes with or without nodule formation, and fibrinous pleuritis.

这6例肺穿的其他共同特征包括肺血管内皮炎、纤维化、淋巴管炎细胞浸润（其内富于浆细胞和组织细胞，伴或不伴淋巴滤泡形成）、纤维素性胸膜炎。

TyPe II collagen induced arthritisln the rat ank1e joint andoVathumin as antigen induced arthritis WA in the rabbit knee joint wereestab1ish2 Qualitative evaluation of me in skin, muscle, synovium, cedilagearound joint and blood was performed by OMA3 The CIA rats were treated on day 7 after hind paw swelling and erythemaAnimals were injected intravenously with ase at a dose of 10mg/kg,tWenty minuots 1ater, one ankle of the rats random1y assigned was exPosedlaser irradiation at l00J/cm fOr l000 seconds, and another ankle wasM grouP wihout laser The other two groups is unmanipulatedcontrol group and untreated CIA group Bimaleolar ankle widthmeasuremellts were taken in all animals every tWo days using amicrometer The histopathology of the ank1e Joint was assessed at day 21after disease onset4 The pro1iferating cell nuclear antigen WCNA of CIA treated by PDT andthe HMME group without laser was doterdrined by immunohistochemiStry5 The AfA rabbits were treated on day 7 after knee swelling and erythemaThe theraPy invo1ved lntravenous injection of l0mg/kg HMME, fOl1owedby 20 minues period in dim light, and transdermal light treatment with\l00 J/cm2 fOr l000 seconds The inner sides of the treated Anees wereirradiated at first, and then the outer side did 24 hours later, the synovialtissue of the Anees joint were removed and in situ cel1 aPoptosis wasdetCCted With tednal deoxync1eotidyl transferase-mediated dUTP nickend labelingR6suIt8:l The pathologic changes of CIA and AIA include subsynovial inflammation,opovial hyPerplasia, pannus formation, cartilage and bone destructionresemble RA.2 The studies demonstrated that there are different uptake of HMME withinskin, muscle, synovium, cartilage and b1ood, and the synovium cou1draPidly uPtake more ase than skin and cartilage at the firSt 30 minuesaller intravenous injection of HMME3 The bimaleolar anke width had no different among PDT treated group,H group withollt 1aser and untreated CIA group But hlstologicalevaluation showed statiStical1y significallt reductions in synovialhyperplasia, pannus formation and cart1lage reosion, bone destruction andtotal score in PDT treated group4 Image analysis showed that the ratlo bforeen the areas of the coufltedobect to that of the entire area in PDTtreated grOup is lower than that in conirol group, but the integrated oPticaldensity had no different between the two groups5 Imape analysis showed that the ratio between the area of the countedobject to that of the e

治疗组在大鼠出现踝关节红肿后1周，炎症达到高峰时进行PDT治疗。随机治疗大鼠一侧的踝关节，另。2。一一侧作单纯HMME 对照。治疗方法是大鼠麻醉后尾静脉注入 HMME10ngkg，20分钟后踝关节照光，激光波长627.sum，功率密度 100mwcm'，照射时间1000秒，能量密度100）／。治疗后避光喂养72 小时。隔日一次测量大鼠的踝关节左右横径，治疗后两周取关节进行病理d 观察。 4。大鼠CIA模型用上述方法进行PDT治疗后，治疗组和单纯HMME 组用兔疫组化SP法检测石蜡切片的核增殖抗原。 5。兔AIA模型在关节炎出现第七天进行PDT治疗，随机治疗一侧膝关节，另一侧作自身对照。兔耳静脉注入I'arrainrelomg／Kg，20分钟后，膝关节用金蒸气激光照射，激光能量密度100）儿旷。24 ／J'时后取膝关节滑膜作病理检查，并用脱氧核昔酸末端转移酶介导的缺口末端标记法原位检测凋亡细胞。结果： 1。模型观察：CIA大鼠炎症高峰期滑膜下炎细胞浸润明显，滑膜细胞明显增殖，炎症达到高峰后二周，血管缀形成，并侵蚀和破坏软骨和骨， CIA模型病理改变与人类RA相似。兔AIA模型膝关节滑膜病理可见滑膜细胞增生，滑膜下炎细胞浸润，也与人类RA滑膜改变相似。 2。关节周围组织中光敏剂含量的测定结果表明，各组织对HMME 的吸收速度和吸收量不同，荧光值一时间曲线不同，滑膜组织比皮肤和软骨对 HMME的吸收多，在 2 0分钟时即有明显差异。 3.PDT对CIA模型的治疗结果表明：PDT治疗后关节炎组、单纯 HMME组和治疗组踝关节左右横径统计学检验差异没有显著性，但病理评分PDT治疗组滑膜增生、血管资形成及软骨破坏、骨破坏和总分比关节炎对照组和HMME对照组好，统计学检验差异有显著性。。3＿军医进修学院硕士学位论文中文摘要 4.PDT治疗组PCNA阳性细胞较对照组少，图像分析结果表明面密度（阳性染色的面积总和与统计视野面积的比值）治疗组小于对照组，统计学检验差异有显著性。。 5.PDT治疗组凋亡阳性细胞较对照组明显增多，图像分析结果单位视野内阳性细胞数和面密度PDT治疗组高于对照组，统计学检验差异有显著性。凋亡细胞核直径PDT治疗组较小，与对照组相比，统计学检验差异有显著性。结论：二。CIA、AIA的病理改变类似人类RA，可作为研究RA病因、发病机制、检查及治疗方法的模型。 2。各组织对HMME的吸收速度和吸收量不同，滑膜组织比皮。

Fluorescein and indocyanine green fundus angiography were used to evalute the macular morphologic results. Results The result of fundus angiography showed that 90 cases 98 eyes had choroidal neovacularization, There were exudation age-related macular degeneration 39 cases (44 eyes), idophaic CNV 23 cases (23 eyes) and highly myopia 22 cases (25 eyes), Polypoidal Choroidal Vasculpathy 4cases (4eyes), multifocal choroidit 1 case (1 eye )and nodifferentiate 1 cases.

结果 90例98只眼黄斑部出血患者的眼底血管造影结果显示有脉络膜新生血管，其中老年黄斑变性湿性型39例44只眼，中心性渗出性脉络膜视网膜病变23例23只眼，高度近视22例25只眼，息肉状脉络膜血管病变4例4只眼，多灶性脉络膜炎1例1只眼，诊断不明1例。

Glucocorticoid: For early skin swelling and serositis, myositis, interstitial lung inflammation, and so effective, and for vascular damage and fibrosis invalid, side effects of high-dose applications, especially for the existing kidney damage Patients easily add vascular damage, and even cause acute renal failure, it is necessary to be careful when using the dosage and the treatment should be individualized, based on clinical performance.

糖皮质激素：对于早期皮肤的肿胀及浆膜炎、肌炎、肺间质炎症等有效，而对于血管损害和组织纤维化无效，大剂量应用时副作用大，尤其是对于已有肾脏损害的患者易加重血管损害，甚至引起急性肾功能衰竭，故使用时须慎重，使用剂量及疗程应个体化，依据临床表现而定。

She is especially good at the management of the eyeground diseases, such as ocular fundus bleeding from various reasons, retinal vascular diseases (such as diabetic retinopathy, retinal vein occlusion, retinal artery occlusion, retinal vasculitis etc.) from diabetes mellitus, hypertension, or various inflammation, retinal capillary hemangioma, vitreous hemorrhage caused by various retinal diseases, optic neuritis, ischemic optic neuropathy, retinal detachment, macular diseases (such as age related macular degeneration, central serous chorioretinopathy, central exudative chorioretinopathy etc.), and other complex diseases such as uveitic diseases and glaucoma etc.

特别是对眼底病如各种原因所致眼底出血；糖尿病、高血压、各种炎症所引起的视网膜血管病如糖尿病视网膜病变、视网膜静脉阻塞、视网膜动脉阻塞、视网膜血管炎症等；视网膜血管瘤病以及其他各种视网膜病所致玻璃体出血；视神经炎、视神经缺血、视网膜脱离、黄斑部疾病如老年性黄斑变性、中浆、中渗等及其他疑难病如葡萄膜炎，青光眼等的诊治积累了大量的临床经验。

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。