血管炎

Results The aorta and its major branches are frequently involved in aortitis syndrome, and the steno-occlusive type is common. CT and MRI can demonstrate variable evolution of vascular lesions.

大动脉炎综合征多部位血管受累多见，以狭窄-阻塞型常见，MR及CT可观察血大动脉炎病变血管壁病理改变。

Objective To investigate the clinical features, causes of blindness and diagnosis of Vogt Koyanagi Harada syndrome Methods The data of 157 patients with VKH syndrome were reviewed and analyzed Patients were carefully examined with slit lamp, ophthalmoscope, three mirror lens, fundus fluorescein angiography, indocyanine green angiography and HLA typing Results Headache was noted in 73 5% of these patients Simultaneous involvement of both eyes occurred in 80 8% of these patients Chroiditis,papilledema and edema of the retina adjacent to the optic nerve were noted in 100% of these patients in the posterior uveitis stage, whereas recurrent granulomatous anterior uveitis (98 4%),"sunset glow" fundus (95 8%) and Dalen Fuchs nodules (71 2%) were the common ocular findings in the recurrent anterior uveitis stage The common causes of blindness were papillitis, exudative retinal detachment and complicated cataract in the posterior uveitis stage, anterior uveal involvement stage and its recurrent stage Poliosis (36 3%) and alopecia (35 0%) were the most common extraocular findings Early irregular patches of fluorescence, followed by localized hyperfluorescent spots were the typical findings of FFA Dilation of choroidal vessels and leakage of ICG from the choroidal vessels were the common ICGA findings The prevalence of HLA DR4 and HLA DRw53 in patients (54 9% and 71 8% respectively) was significantly higher than that in controls (14 7% and 38 2% respectively) Conclusions VKH syndrome is characterized by chroiditis, papillitis or neuroretinitis in the posterior uveitis stage, followed by a generalized uveitis with a typical recurrent granulomatous anterior uveitis Extraocular findings and relevant examinations including FFA, ICGA and HLA typing are helpful to the diagnosis of VKH syndrome

目的探讨Vogt-Koyanagi-Harada综合征患者的临床特征、盲目原因及诊断等有关问题。方法对在1996年1月至2000年12月间就诊资料完整的157例VKH综合征患者进行回顾性分析，并对裂隙灯、眼底镜、三面镜、荧光素眼底血管造影(fundus fluorescein angiography，FFA)、吲哚青绿血管造影(indocyanine green angiography，ICGA)及人类白细胞抗原分型等检查结果进行分析。结果 VKH综合征最常见的前驱症状为头痛(102例，73.5%)，双眼同时患病118例(80.8%)；后葡萄膜炎期眼部主要表现为脉络膜炎、视乳头及附近视网膜水肿(100.0%)；前葡萄膜炎反复发作期眼部表现为复发性肉芽肿性前葡萄膜炎(128例，98.4%)、晚霞状眼底改变(95.8%)及Dalen-Fuchs结节(71.2%)；后葡萄膜炎期、前葡萄膜受累期及前葡萄膜炎反复发作期导致盲目的主要原因分别为视乳头炎、视网膜脱离及并发性白内障；毛发变白(36.3%)及脱发(35.0%)是最常见的眼外表现；炎症活动期FFA典型表现为斑驳状高荧光，ICGA发现脉络膜血管扩张、通透性增高等改变；VKH综合征患者HLA-DR4及HLA-DRw53的阳性率(54.9%及71.8%)显著高于正常对照组(14.7%及38.2%)。结论 VKH综合征患者在后葡萄膜炎期眼部典型表现为双侧脉络膜炎、视乳头炎或神经视网膜炎，随后出现以反复发作的肉芽肿性前葡萄膜炎为特征的全葡萄膜炎。眼外症状及相关的辅助检查包括FFA、ICGA 及HLA分型等有助于VKH综合征的诊断。

Mirror infiltrating the cancer vagina the image is that the blood vessel is abnormal mainly,original place cancer vagina mirror visible image acetic acid white epithellum,major partners the shape blood vessei,heterotype blood vessel,mosaic and floccosoids wait a little bit;CIN acetic acid white maximum appears on epithelium,the shape blood vessel,heterotype blood vessel,rnosaic and floccosoids take second place;The chronic cervicitis gives first place to no representative shape blood vessel China and acetic acid white epithelium.

浸润癌阴道镜图像主要是血管异常，原位癌阴道镜图像可见醋酸白色上皮，多数伴有点状血管、异型血管、镶嵌和白斑等；CIN醋酸白色上皮出现最多，点状血管、异型血管、镶嵌和白斑次之；慢性宫颈炎以不典型点状血管和醋酸白色上皮为主。

Mirror infiltrating the cancer vagina the image is that the blood vessel is abnormal mainly,original place cancer vagina mirror visible image acetic acid white epithellum,major partners the shape blood vessei,heterotype blood vessel,mosaic and floccosoids wait a little bit;CIN acetic acid white maximum appears on epithelium,the shape blood vessel,heterotype blood vessel,rnosaic and floccosoids take second place;The chronic cervicitis gives first place to no representative shape blood vessel China and acetic acid white epithelium.

浸润癌阴道镜图像主要是血管异常，原位癌阴道镜图像可见醋酸白色上皮，伴有点状血管、异型血管、镶嵌和白斑等；CIN醋酸白色上皮出现最多，点状血管、异型血管、镶嵌和白斑次之；慢性宫颈炎以不典型点状血管和醋酸白色上皮为主。

Twelve hours latter,uterine vessels formation was revealed by tannin-Fe lavement solution.Results The uterine vessel formation of rats in the model group showed that varices,tetanic shape,the density of all levels vessel net increased obviously and its twist,serpentine shape decreased markedly,while that in the large,middle dosage Gongning groups displayed absolute contrarily and fit like a glove with the normal control group.The uterine vessel formation of rats in the small dosage Gongning group and indomethacin group also showed the same transformation as it in the model group.

结果 模型组大鼠子宫各级血管扩张增粗，走行僵直，螺旋状和蜿蜒状走行消失或明显减少，血管形成的各级血管网密度增加，分布不均；消炎痛组、宫宁小剂量组子宫血管仍存在较明显的血管腔扩大、走行僵直和血管网密度增加，宫宁大、中剂量组子宫血管构筑的异常改变消失或明显改善。

Results:(1) FSN can inhibit secondary joints swelling and multi-arthritis evidently, improve the whole condition of rats; at the same time, it can also lighten the synovial inflammation and hyperplasia of lesion joints distinctly, and prevent the joint cartilage and bone from destruction; the collective efficiency of FSN is better than TWP.(2) FSN can raise AA rats low LTT of spleen to normal nearly, remedy the disorder of Th / Ts and Thl / Th2 cells balance in peripheral blood, restrain exorbitant TNF- a ? IL-1 produced by PM O , thereof exert anti-inflammatory and immunoregulation effect.(3) Inside the lesion joints, FSN can depress abnormal hyper-expression of TNF- a mRNA and NF-kB in synovial tissues, as well as advance the expression of Caspase-3 (a proteolytic enzyme of apoptosis), reduce synovial immflamination and proliferation.(4) FSN can lower the expression of VEGF in synovial tissue,reduce neogenetic veins, so inhibit the growth of pannus tissue and the damage of cartilage and bone by that.(5) The above effect of FSN are in proportion to its dosage.Conclusions: FSN has inhibitory effects on symptom and condition of experimental RA, which is better than TWP as a whole.

结果：(1)FSN有明显的抗炎作用，可显著抑制AA大鼠足跖肿胀与多关节炎，改善大鼠的全身情况，同时明显减轻病变关节滑膜炎症与增生，防止关节软骨及骨质的破坏，其综合作用优于TWP；(2)FSN还能使AA大鼠低下的脾LTT恢复至接近正常，纠正外周血中T细胞亚群Th／Ts及Th1／Th2平衡紊乱，抑制大鼠PHφ过高的TNF-α、IL-1分泌，而发挥抗炎和免疫调节作用；(3)在病变关节局部，FSN能显著抑制AA大鼠滑膜细胞异常增高的TNF-αmRNA的表达，降低滑膜组织中NF-kB表达，并增加凋亡蛋白酶Caspase-3表达，从而抑制滑膜的炎症与增殖；(4)FSN还可下调滑膜组织中VEGF表达，减少血管新生，由此抑制血管翳的形成及其对软骨和软骨下骨的侵蚀；(5)FSN的上述作用皆呈现一定的量效依赖关系，高剂量组作用优于低剂量组。

FSN can raise AA rats low LTT of spleen to normal nearly, remedy the disorder of Th/Ts and Th1/Th2 cells balance in peripheral blood, restrain exorbitant TNF-α、IL-1 produced by PMφ, thereof exert anti-inflammatory and immunoregulation effect.(3) Inside the lesion joints, FSN can depress abnormal hyper-expression of TNF-αmRNA and NF-kB in synovial tissues, as well as advance the expression of Caspase-3 (a proteolytic enzyme of apoptosis), reduce synovial immflammation and proliferation.(4) FSN can lower the expression of VEGF in synovial tissue, reduce neogenetic veins, so inhibit the growth of pannus tissue and the damage of cartilage and bone by that.(5) The above effect of FSN are in proportion to its dosage. Conclusions: FSN has inhibitory effects on symptom and condition of experimental RA, which is better than TWP as a whole.

结果：(1)FSN有明显的抗炎作用，可显著抑制AA大鼠足跖肿胀与多关节炎，改善大鼠的全身情况，同时明显减轻病变关节滑膜炎症与增生，防止关节软骨及骨质的破坏，其综合作用优于TWP；(2)FSN还能使AA大鼠低下的脾LTT恢复至接近正常，纠正外周血中T细胞亚群Th/Ts及Th1/Th2平衡紊乱，抑制大鼠PMφ过高的TNF-α、IL-1分泌，而发挥抗炎和免疫调节作用；(3)在病变关节局部，FSN能显著抑制AA大鼠滑膜细胞异常增高的TNF-αmRNA的表达，降低滑膜组织中NF-kB表达，并增加凋亡蛋白酶Caspase-3表达，从而抑制滑膜的炎症与增殖；(4)FSN还可下调滑膜组织中VEGF表达，减少血管新生，由此抑制血管翳的形成及其对软骨和软骨下骨的侵蚀；(5)FSN的上述作用皆呈现一定的量效依赖关系，高剂量组作用优于低剂量组。

Fatigue is a widespread symptom in numerous neuroimmunological diseases like multiple sclerosis, myasthenia gravis, morbus Behcet, neurosarcoidosis, neuroborreliosis or immune vasculitis.

疲劳是为数众多的神经免疫疾病如多发性硬化、重症肌无力、贝切特病、神经肉瘤病、神经包柔螺旋体病或免疫性血管炎中的常见症状。

Fatigue is a widespread symptom in numerous neuroimmunological diseases like multiple sclerosis, myasthenia grais, morbus Behcet, neurosarcoidosis, neuroborreliosis or immune asculitis.

疲劳是为数众多的神经免疫疾病如多发性硬化、重症肌无力、贝切特病、神经肉瘤病、神经包柔螺旋体病或免疫性血管炎中的常见症状。

The relationship between sex,age,anemia,hypertension,Raynaud′s phenomenon,vasculitis,renal involvement,anticardiolipin antibodies,Cushing syndrome,glucocorticosteroid dosage,immunosuppresive agents and AVN of bone was analysed.

分析性别、年龄、贫血、高血压、雷诺现象、血管炎、肾脏受累、抗磷脂抗体、柯兴征以及糖皮质激素用量和免疫抑制剂的应用与AVN发生的关系。

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。