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Therefore, the purposes of this paper are on, firstly, the possible difference of secret of vasoactive substances from pulmonary artery and aortic artery endothelial cells; secondly, the regulatory effect of pulmonary microartery endothelial cella on the movement of pulmonary artery.

所以本文的研究目的为:1研究肺动脉内皮细胞和主动脉内皮细胞分泌血管活性物质的可能差异:2研究肺微动脉内皮细胞对肺动脉血管运动的调节作用;此外,基于我室以往对吸烟和肺血管反应性的研究。

Introductionratherosclerosis and hypertensin are associated with adherence of blood cell, thrombosis, vasoconstriction and proliferation of vascular smooth muscle.

血管内皮细胞能合成合释放多种血管活性物质,对维持血管的舒缩,抑制血小板的聚集及平滑肌的增殖均具有重要意义。

Vascular endothelial cell injury caused by the imbalance of secretion vasoactive substances as well as its activity changes has played an important role in the process of preeclampsia development.

血管内皮细胞损伤所致血管活性物质的分泌失衡以及活性的改变,在子痫前期的发生发展过程中起着重要的作用。

The major results obtained are: PCR-RFLP method is suitable for molecular identification of Shihu; 205 compounds were isolated from 10 species of Dendrobium, including 21 new compounds, and 28 compounds isolated from genus Dendrobium for the first time. Each of the extracts and compounds were screened for anticoagulant and antitumour activities separately. The results indicated that the ethyl acetate extract from Dendrobium chrysanthun has significant anticoagulant function; the antitumour function of the 4 bibenzyl components from Dendrobium chrysotoxum is stronger than that of phenanthrene, of which the erianin has significant anti-angiogenic effect both in vivo and in vitro; components with moderate or stronger antitumour activities were found in the extracts of D. thyrsiflorum, D. chrysanthun and D. trigonopus; quality standard for 5 species of Dendrobium was drawn up use active or indicative components as control.

重要研究结果有:经方法学研究,认为PCR-RFLP法适于作为石斛属药材分子标记鉴定方法;对10种石斛进行化学成分分离鉴定,共分得205个化合物,其中新化合物21个,首次从石斛属分得的28个;对提取物和各单体化合物分别作抗凝血、抗肿瘤等活性筛选,结果说明束花石斛乙酸乙酯部位有显著的抗凝血作用,鼓槌石斛的4个联苄类成分抗肿瘤作用强于菲类,联苄类毛兰素在体内外有显著抗血管生成活性,球花石斛、束花石斛及翅梗石斛均筛到中等或较强抗癌活性的成分;选择有活性或指标性成分作对照品,对5种石斛草拟了质量标准。

Objective To study the relationship between plasma level of nitric oxide and hemodynamic changes in diabetes mellitus.

目的 为了研究血管内皮细胞合成分泌的血管活性物质一氧化氮在糖尿病人及血管并发症中的变化。

At present,with the increasing studies on neuropeptide,many of them have shown that substance Pand vasoactive intestinal peptideare closely related to the occurrence of nasal polyps and colorectal polyps which are similar to the occurrence and pathology of vocal cord polyps.This article will discuss these aspects in order to investigate the relationship between SP,VIP and vocal cord polyps.

目前,随着人们对小分子神经肽研究的增多,P物质及血管活性肠肽和鼻息肉、直肠息肉等的发生之间的密切相关性已受到许多学者的证明和肯定,而声带息肉的发生、病理与鼻息肉及直肠息肉有相似之处,现拟从以上方面进行论述,以探讨P物质及血管活性肠肽与声带息肉发生的相关性。

We found for the first time that the epithelium of bronchus of normal broilersexpressed iNOS mRNA.iNOS activity in the epithelium of bronchus of preascitic andascitic broilers were higher than normal broilers,but there was no iNOS activity inpulmonary vessels of all the three types broilers.The results indicated that the increasedNOS expression in pulmonary vessels of preascitic and ascitic broilers was not iNOS.

首次发现在肉鸡肺动脉高压发展过程中,肺血管NOS的表达是增加的,尤其是正常鸡无NOS表达的肺小血管内皮和平滑肌在腹水鸡却呈高水平表达,且NOS活性增加的肺小血管也同时存在管壁平滑肌层增厚或无肌型血管肌化的结构重建现象,结果提示NOS表达增强可能与肺血管中膜增厚有关。

Specifically, the invention relates to vasoactive intestinal receptor binding peptides, derivatives and analogues of vasoactive intestinal peptide, and embodiments of such peptides radiolabeled with a radioisotope, as well as methods and kits for making, radiolabeling and using such peptides for radiodiagnostic and radiotherapeutic purposes.

具体地,本发明涉及到具血管活性肠受体结合特性的肽,血管活性肠肽的衍生物和类似物,和用放射性同位素标记这类肽的实施方案,以及生产、放射性标记与使用这类肽的方法和药盒进行放射性诊断和放射性治疗。

These findings suggest that NC (13-17) may play important roles in pain modulation at supraspinal level in mice and elicits these effects through a novel mechanism independent of the NC receptor and the traditional opioid receptors The bioactivity study of NC related peptide-NST showed that: NST could dose-dependently reverse the effects of NC in antagonizing EMs-induced analgesia; NST itself could increase the MAP and HVBR of rat, and the tension of rabbit isolated aorta muscle strips.

对孤啡肽相关肽—NST的生理活性研究发现,NST可以剂量依赖的拮抗NC对抗内吗啡肽-1和内吗啡肽-2的镇痛作用;NST对NC的降低大鼠平均动脉压作用无显著影响,但其本身可以升高大鼠的平均动脉压,后肢灌流压和离体血管条的张力,在心血管系统方面是一个新的生物活性肽。

Endothelin-1 (ET-1) is a potent vasoconstrictive peptide that was isolated initially from the conditioned medium of cultured endothelial cells. It is a pathogenic mediator with a number of deleterious effects, including vasoconstriction, fibrosis, vascular hypertrophy,and inflammation.Atrial natriuretic peptide, angiotensin II and nitric oxide also takes an important role in cardiovascular system.

内皮素-1(endothelia-1,ET-1)是一种由内皮细胞合成和分泌的、具有强烈收缩血管作用和促进细胞增生的血管活性多肽,心钠素(atrialnatriuretic peptide,ANP)、血管紧张素Ⅱ(angiotensin Ⅱ,AⅡ)、NO等在心血管系统功能的调节中也起着重要作用。

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