血管活性的

In clinical. acetylcholinesterase inhibitors reduce the breakdown of synaptic acetylcholine, have been modestly effective in improving the cognitive deficits of Alzheimer's disease.The goal of this work is to determine enzyme kinetics and mechanisms of acetylcholinesterase and butyrlcholinesterase inhibition by five cardiovascular drugs, lovastatin, simvastatin, amlodipine besylate, nifedipine, and hydralazine hydrochloride, and two benzodiazepines, diazepam and chlordiazepoxide hydrochloride. All drugs in this study are reversible mixed-type inhibitors of acetylcholinesterase and butyrylcholinesterase. The pKi values for acetylcholinesterase and butyrylcholinesterase inhibition by the cardiovascular drugs are linearly correlated with the molecular weights of the drugs with the slopes of 0.005 and 0.0021, respectively. Therefore, van der Waals' interactions between acetylcholinesterase and the cardiovascular drugs are stronger than those between butyrylcholinesterase and the drugs. This is probably due to a smaller active site gorge and a more significant peripheral anionic substrate binding site of acetylcholinesterase than those of butyrylcholinesterase.

本研究之目的系决定乙醯胆碱酯酵素和丁醯胆碱酯酵素被五种心脏血管药物lovastatin， simvastatin， amlodipine besylate， nifedipine、hydralazine hydrochloride和两种benzodiazepines：diazepam和Chlordiazepoxide hydrochloride的抑制作用之动力学及机转，这些药物都是乙醯胆碱酯酵素和丁醯胆碱酯酵素的可逆性、混合型之抑制剂，实验结果显示，五种心血管药物对於乙醯胆碱酯酵素及丁醯胆碱酯酵素抑制之pKi值和药物之分子量呈直线之关系，斜率分别为0.005及0.0021因此丁醯胆碱酯酵素，与心血管药物间之凡德瓦作用（van der Waals' ）比乙醯胆碱酯酵素与心血管药物间者弱，这可能原因是丁醯胆碱酯酵素之活性区域比乙醯胆碱酯酵素之活性区域更宽广，但丁醯胆碱酯酵素之周边阴离子区域不及乙醯胆碱酯酵素之周边阴离子区域者明显重要，由於五种心血管药物对於乙醯胆碱酯酵素和丁醯胆碱酯酵素抑制之pKi值存在著线性关系表示此种抑制作用系经过共同之反应机理。

The authors consider that is abnormal coagulation in steroid-i nduced necrosis of femoral head,and it might be caused by exogen ous steroid damaged the vascular endotheliod of those intraosseous and extraosse ous;or the platelet and other coagulable active mass be actived by immunocomp lex deposited in the vascular wall.

认为激素性股骨头缺血坏死发病过程中，系统存在异常的凝血状态。这种异常的凝血状态很可能是外源性激素造成了骨内外血管内皮损害或免疫复合物沉积在血管壁，进一步激活了血小板及其它凝血活性物质后引起的。

Compared with ribonuclease A, the ribonuclease activity of Ang is very low, but is very important to promote new endothelia proliferation.

研究表明，Ang的血管生成活性与该蛋白表面的两个活性位点有关：一个裂解RNA，另一个与细胞受体结合。

Because the objects of medicine are the "animate things", composed of active organs such as hair, skin, muscle, bone, marrow, nerve, blood, water, blood vessel, brain, heart, liver, lung, pancreas, spleen, kidney, stomach, intestine, gallbladder, bladder, nose, ear, eye and sexual organs and the above mentioned active organs can be divided into living matter of different kinds of cells; thereinto, men have penis, testicle and epididymis, spermaduct, sperm, breast undevelopment, androgen production etc.

因为，医药的对象是人类为"活物"，人类均由毛、皮、肌、骨、髓、神经、血液、水液、血管、脑、心、肝、肺、胰、脾、肾、胃、肠、胆、膀胱、鼻、耳、目、两阴等活性组织器官组成。前述活性组织器官还分有各种不同细胞的生命物质等。其中，男人有阴茎、睾丸和附睾丸、输精管、精液、乳房不发育、产生雄激素等。

It is showed that the mechanism of XSTM was association with inhibiting expression of cell adhesion molecules of endothelium and inflammatory cell infiltrating into vessel wall, promoting fibrinolytic activity,inhibiting platelet adhesion and aggregation, regulating angiotasis, protecting the normal endothelium structure and function, inhibiting collagen hyperplasia and maintaining elasticity of vascular wall.

实验结果表明：消栓通脉颗粒剂具有显著抑制细胞黏附分子——P-选择素的表达，抑制炎性细胞的浸润，促进纤溶活性，抑制血小板黏附、聚集，调节血管张力，保护血管内皮细胞功能，抑制胶原纤维增生，维持静脉壁弹性等治疗作用。

The immunological competence of the expressed protein was tested by means of Western blotting and enzyme-linked immunosorbent assay, and its biological activity was assayed by chicken chorioallantoic membrane and Matrigel angiogenesis assay.

酶联免疫吸附和Western blot技术检测纯化的VEGF165蛋白免疫学活性，鸡胚尿囊绒毛膜实验和matrigel血管形成实验检测其生物学活性。

Aim: To establish a hypoxia model of human umbilical vein endothelial cells-12 (HUVEC-12) with stimulating of Cobaltous chloride in vitro, and investigate activity of human endothelial nitric-oxide synthase promoter.

目的：建立氯化钴诱导的人脐静脉血管内皮细胞－12(HUVEC-12)缺氧模型，研究人血管内皮细胞一氧化氮合酶基因的启动子活性变化。

There exists an obvious hypercoagulable state in patients with leukemia. The activation of platelet, fibrinolytic system and the injury of vascular endothelium in patients with leukemia may be the causes of bleeding.

白血病病人存在明显的高凝状态，表现为血小板活性增加及血管内皮细胞损伤，抗凝活性降低及继发纤溶功能亢进。

These include physical characteristics, such as repulsive forces resulting from the electronegative charge of both platelet and endothelial cell membranes, and biochemical attributes, such as the synthesis and release of inhibitors of platelet activation. Platelets respond rapidly to alterations of endothelial cells and to exposure of subendothelial structures by attaching firmly to the site of the lesion.

正常情况下，循环中的血小板与血管壁内皮细胞层紧密接触但不发生黏附，是因为血管内皮细胞具有一定的活性功能，包括一些物理特性如血小板和内皮细胞膜均带有负电荷产生相互排斥作用以及生化作用如合成和释放血小板活化抑制剂。

Weibel-Palade bodies are specialized cigar-shaped secretory organelles in endothelial cells, which contain a variety of biologically active molecules. These contents can be released rapidly by stimulation and involved in hemostasis, inflammation and angiogenesis.

Weibel-Palade小体(Weibel-Palade body， WPB)是血管内皮细胞一种特殊的分泌性杆状细胞器，含有多种生物活性分子，受到刺激后可以非常迅速的释放这些内容物，参与止血、炎症和血管生成等生理功能。

However, as the name（read－only memory）implies, CD disks cannot be written onorchanged in any way.

然而，正如其名字所指出的那样，CD盘不能写，也不能用任何方式改变其内容。

Galvanizes steel pallet is mainly export which suits standard packing of European Union, the North America. galvanizes steel pallet is suitable to heavy rack. Pallet surface can design plate type, corrugated and the gap form, satisfies the different requirements.

镀锌钢托盘多用于出口，替代木托盘，免薰蒸，符合欧盟、北美各国对出口货物包装材料的法令要求；喷涂钢托盘适用于重载上货架之用，托盘表面根据需要制作成平板状、波纹状及间隔形式，满足不同的使用要求。