血管活性的

The new structure compounds (4, 54, 56) possessing vasodilatation were found. These compounds may be as lead compounds of developing antihypertension drugs. The synthesis method of peptidemimetics containing β-tetrahydro -carbolic acid was established for the first time.

在对上述化合物NO清除能力评价实验中，发现了一类具有舒血管活性新化合物（化合物4，54，56），这一类具有舒血管活性化合物的发现可以为研制高血压治疗药物提供先导化合物。

The variation of plasma vasoactive peptide concentration was not only related to UAP attack but also significant to the maintance coronary diastole and corculation.

UAP的发生与血管活性肽的变化密切相关，血管活性肽对维持冠脉舒张和循环有重要意义。

The degradating and redistributing of ECM were migration of VSMC and vascular remodeling through inhibiting the production of PDGF-BB and the activation of MMPs so to prevent the vascular stenosis.⑤Orthotopic hybridism in situ: The expression of MMP-3 increased after operation, the tendency and intensity were parallel to the expression of NF-κB. Tongxinluo could decrease the expression of MMP-3 and NF-κB. The study showed that the producting and activating of MMP-3 were modulated by NF-κB. The inhibition to the producting and activating of MMp-3 of Tongxinluo was mediated by inhibiting the activating of NF-κB. Conclusion ①The rabbit vascular stenosis model could be established successfully by plain balloon damage, the operation process was easy, economical and practical.

①单纯球囊损伤可成功建立典型家兔血管狭窄模型，操作方法简单，经济实用；②以VSMC增殖、迁移为主的内膜增厚以及以ECM降解、合成与再分布所致的血管重构是导致受损血管狭窄的根本原因；③通心络能明显抑制VSMC的增殖、迁移和ECM降解、合成，阻止血管内膜增生和血管重构，防止受损血管狭窄；该作用可能与其减少和阻止PDGF-BB的产生和活性，以及抑制MMPs的表达和恢复MMPs/TIMPs平衡有关；④通心络能显著抑制球囊损伤后血管内膜增生和血管重构，可能与其保护血管内皮，改善内皮功能，增加血清NO含量有关；⑤通心络抑制内膜增生和血管重构，减轻受损血管狭窄，还可能是通过抑制NF-κB的活化途径而起作用的。

Constituting a tube; having hollow tubes同义词:tubular, cannular, tubelike, tube-shaped vasoactive

a。 血管活性的，(尤指在血管的舒张或收缩方面)作用于血管的，影响血管的 vasoconstriction

Although the catalytic activity of angiogenin is rather weak, it is critical for its angiogenic properties.

血管生成素的核糖核酸酶活性很弱，但对它的血管生成活性是至关重要的。

In physiolgoical state,the action of traditional RAAS on blood pressure might be decreased with age in aged people,and the vasoactive peptides might contribute more to the cardiovascular action to keep blood pressure stable. Activity of vasoconstrictive peptides were incresaed and activity of vasodilative peptide was decreased.

老年人随着年龄的增长，在生理状态下传统的RAAS的作用减弱，更多的是血管活性肽(ANP，ET，CGRP)参与心血管活性的调节，老年EH患者缩血管肽ET的活性增高、舒血管肽CGRP活性减弱。

Between women with or without endometriosis, the expression of VEGFmRNA of eutopic endometrium in the secretoiy phase was significantly higher than that in the proliferative phase(P.05). eutopic endometrium of women with endometriosis both in the proliferative phase and secretoiy phase expressed higher level VEGFmRNA than that in control group(P.05). Conclusion:①The expression of VEGF is adjusted by female'hormone.②VEGF is a very important factor that may contribute to the pathegenesis of endometriosis by promoting neovascularization,explanting of ectopic endometrium , increasing activity of angiopoiesis in eutopic endometrium③VEGF is a efficient organism maker to reflect invading growth, prognosis and metastasis potency of EMs.④VEGF may paly an important role in both pathogenesis and progress of endometriosis.

EM 患者VEGF 水平受女性性激素周期性调节；VEGF 是导致EM 发生特别是在位内膜血管活性增强、异位内膜种植、新生血管形成的重要机制，提示血管生成是EMs 发生中的一个重要因素；VEGF 可能不仅参与EM 的形成，并与进一步发展存在关系，提示血管生成在异位子宫内膜的种植、浸润中可能起着重要的病理生理作用，是EM 发病的必要环节；VEGF 是反映EM 侵袭生长、转移潜能、预后的有效生物指标，提示通过使用抗血管生成药物或抗血管生长因子抗体，来阻断血管生成，极有可能成为EM 在现有药物和手术治疗基础上的一种有效治疗策略和靶点。

Abstract］ Objective To assess the endothelium-dependent relaxation in patients with essential hypertension or hypertension smokers by color Doppler flow imaging.Methods With intermittent ultrasound imaging and power Doppler imaging,we measured endothelium-dependent relaxing function in 72 subjects 24 of whom with essential hypertension,24 of whom with both hypertension and smokingand the others as normal control.We measured the diameter of the superficial femoral and brachial arteries at rest,during reactive hyperaemia,re-test and after sublingual glyceryl trinitrate for evaluating the endothelium-independent dilatation in subjects.The level of plasma NO,ET,PGI2,and TXB2 were determined.

摘要］ 目的探讨原发性高血压及高血压合并吸烟患者血管内皮依赖性舒张功能的改变方法采用彩色普勒高频超声的间歇成像和能量多普勒成像，对24例原发性高血压患者、24例高血压合并吸烟患者及24例正常血压无吸烟史者的血管内皮依赖性舒张功能，包括静息时血管内径、增加流量引起的血管舒张、硝酸甘油引起的血管舒张等，以及对血浆氧化氮、内皮素、血栓素B2（TXB2）和列腺环素（PGI2）等血管活性物质进行检测并比较分析。

The laboratory research and chinical trials to prove.courage lcecontains active material that it can quickly penetrate through body's cell.so to directly provides for the cell,fill the skin intercellular space the crevice which is senile withered because of the cell stays benind supply the active elements necessary for the body cells metabolism,to activate the function of endothelium cells of blood vessels,promote the blood vessels balance, compose and secrete various blood vessels active elements,contains abundantsulfuric cartilage element,sulfuric amido etc.,all of fatty acid in human body.and it can accelerete the re-generation of blood cells,add the quantity of the hemoglobin and red blood corpuscle so to improve the blood parameter,and fundamentally improve the body cells metabolism and nutrition supply for all the organs,as a result,you will thoroughly refresh yourself and bloom vitality of youth.

实验室研究和临床试验证明，LCE所含活性物质能够迅速穿透人体细胞，直接为细胞供养，填补肌肤细胞间因细胞衰老干瘪而留下的空隙全面补充人体细胞新陈代谢所必须的活性物质，激活血管内皮细胞功能，促进血管平衡，合成和分泌多种血管活性物质：富含的硫酸软骨素、硫酸氨基葡萄糖等能改善和调节人体脂代谢，有效清除体内血液中多余的脂质和脂蛋白清除在血管壁内膜沉积的脂类物质，保持人体脂肪酸均衡：能够加快血液细胞更新，提高血液中的血红蛋白和红血球数量，改善血液参量，从根本上改善人体细胞的新陈代谢，改善人体各组织器官的营养供给，使人由内而外脱胎换骨，重新焕发青春活力。

The laboratory research and chinical trials to prove.courage lcecontains active material that it can quickly penetrate through body's cell.so to directly provides for the cell,fill the skin intercellular space the crevice which is senile withered because of the cell stays benind supply the active elements necessary for the body cells metabolism,to activate the function of endothelium cells of blood vessels,promote the blood vessels balance, compose and secrete various blood vessels active elements,contains abundantsulfuric cartilage element,sulfuric amido etc.,all of fatty acid in human body.and it can accelerete the re-generation of blood cells,add the quantity of the hemoglobin and red blood corpuscle so to improve the blood parameter,and fundamentally improve the body cells metabolism and nutrition supply for all the organs,as a result,you will thoroughly refresh yourself and bloom vitality of youth.

实验室研究和临床试验证明，LCE所含活性物质能够迅速穿透人体细胞，直接为细胞供养，填补肌肤细胞间因细胞衰老干瘪而留下的空隙全面补充人体细胞新陈代谢所必须的活性物质，激活血管内皮细胞功能，促进血管平衡，合成和分泌多种血管活性物质：富含的硫酸软骨素、硫酸氨基葡萄糖等能改善和调节人体脂代谢，有效清除体内血液中多余的脂质和脂蛋白清除在血管壁内膜沉积的脂类物质，保持人体脂肪酸均衡：能够加快血液细胞更新，提高血液中的血红蛋白和红血球数量，改善血液参量，从根本上改善人体细胞的新陈代谢，改善人体各组织***的营养供给，使人由内而外脱胎换骨，重新焕发青春活力。

As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸，那乌黑、忧郁的眼睛，她便会相信，他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失