血管抑制神经

He angiogenesis and tumor growth of human neuroblastoma can also be effectively inhibited by TrkA gene.

rkA基因能降低NB细胞的致瘤性及抑制神经母细胞瘤的血管生成和肿瘤生长。

According to Chair of Department of Neurology, Taipei Veterans General Hospital, Shuu-Jiun WANG, the activation of trigeminal vascular system in the brain is commonly regarded as the pathogenic mechanism for sick headache and cluster headache. Stick to this premise, the research team hypothesizes that the system activator Nociceptin and the system inhibitor Orexin A these two kinds of neuroproteins are related to the pain degree of migraine and cluster headache.

北荣神经内科主任王署君表示，脑内三叉神经血管系统活化与否，是医界公认的偏头痛与丛发性头痛致病机转，故研究团队推测，可活化该系统的致痛素，以及抑制该系统的下视丘素两种神经蛋白质，应与偏头痛与丛发性头痛的程度有关。

Cells that secrete serotonin, a vasoconstrictor neurotransmitter in the CNS that also inhibits gastric secretion and stimulates smooth muscle.

分泌血清素，一种血管收缩的神经递质在也抑制胃分泌并且刺激平滑肌的 CNS 内的细胞。

It participated in message delivery and coordination between nerves and vessels, and regulated viscera function in nervous system.

它在心血管系统能维持血管平滑肌的紧张度、抑制血小板聚集、粘附和调节血管平滑肌细胞增生；在神经系统它参与信息传递、神经和血管间的协调和内脏功能的调节。

Studies also indicated that genistein exsists not only in soybeans but also in many kinds of plants such as vegetables and fruits.As a potential anticancer agent, the actional mechanisms of genistein mainly includes as follows:First, genistein can depress the activity of protein tyrosine kinase and transduction pathways for the phosphorylation of receptors and mitosis signal. So genistein can lead to cells' proliferation depressed. Second, genistein has minimal effects of phytoestrogens. It can be combined with estrogen receptor and improve the synthesis of cellular sex hormone binding glulobin, and improve the activity of UDP-glucuronyl transferase. Through these pathways, it can inhibit the cell activity of breast cancer and prostate cancer.

作为一个很有潜力的抗肿瘤物质，三羟异黄酮的作用机制主要包括：①抑制蛋白酪氨酸激酶活性，可阻抑PTK引起的受体磷酸化和有丝分裂的信号传递，导致癌细胞增殖受抑；②弱雌激素作用：可通过与体内雌激素受体结合，并可增加细胞内性激素结合球蛋白的合成，增加UDP-葡糖醛酸转移酶的活性等途径抑制乳腺癌和前列腺癌细胞活性；③拓扑酶Ⅰ和Ⅱ抑制剂，抑制细胞活性；④上调细胞周期性负性调节因子P21WAF1/CIP1的表达，使之负性调节因子作用增强；⑤可阻止胰岛素样生长因子-Ⅰ、肝细胞生长因子和神经生长因子的作用而抑制肿瘤生长；⑥其他：抗氧化作用、抑制热休克蛋白、诱导细胞凋亡、抑制新生血管生成和抑制多种耐药相关蛋白等。

Pigment epithelium-derived factor, is a serine protease superfamily member. It has highly conservative sequence and unique molecular structure with neurotrophy, inhibiting angiogenesis,anti-tumor and a variety of functions It is now investigated as a hot spot. The function of anti-angiogenesis is particularly important.

摘要色素上皮衍生因子，是丝氨酸蛋白酶超家族成员，它具有高度保守的序列和独特的分子结构，因具有神经营养，抑制新生血管，抗肿瘤等多种功能而成为研究的热点，其抗新生血管的功能尤为重要。

These growth factors have the effects of neurogenesis, angiogenesis, neurotrophy, inhibitory excitoxity induced by glutamate and NMDA, and anti-oxidative, by these ways they can prevent neural cells from death.

这些生长因数均有保护神经细胞避免因为脑损伤而造成的死亡，其作用有神经生长性、血管生长性、神经滋养性、抑制麸氨酸盐与NMDA所引发的兴奋性毒性及抗氧化作用，但是这些仅限於动物模式，应用於临床还有一段艰辛的历程。

A prominent visible blood vessel in the pontocerebellar angle was noted in the affective side, but no similar finding was noted in the non-affective side. In conclusion, acupuncture may improve facial spasm, this effect of acupuncture probable mediates via a antidromic impulse of facial nerve to decrease intensity of impulse that is orthodromic transmission from facial motor nucleus or from focal demyelization of neurovascular compression; acupuncture evoked cerebral cortex to produce a descending inhibiting impulse to inhibit the hyperexcitablity of facial motor nucleus to improve facial spasm.

结论是针刺可以改善颜面肌痉挛，针刺可能经由诱发颜面神经逆行的神经冲动减少颜面运动核或神经血管压迫之focal demyelination处往下而来神经冲动的强度；或者针刺诱发大脑皮质产生抑制性下行神经冲动抑制颜面运动核的过度兴奋来改善颜面肌痉挛。

The identification of protein were performed by searching the mass spectrometry data from the NCBInr database using the software of Sequest Bioworks3. 2. The results indicated that over 25 protein components including acid and basis phospholipase A2, nerve growth factor, presynaptic neurotoxin, hemorrhagic factor, thrombin-like enzyme, serine protease, glycogen synthase, metalloproteinase, maturase, L-amino acid oxidase, plasminogen activator, adhesion, cysteine-rich secretory protein, disintegrin, fibronectin-binding protein, fibrinogen clotting inhibitor A chain, vascular apoptosis-inducing protein 1, pyranose 2-oxidase, carbamoyl-phosphate synthase, as well as the homology proteins of snake venom ablomin, ablomin, catrin, mucrofirase, pallabin, salmosin and triflin homologues were identified from the GSSV.

从GSSV中鉴定出超过25种蛋白组分，主要包括：酸性磷脂酶A1、碱性磷脂酶A2、神经生长因子、突触前神经毒素、出血因子、类凝血酶、丝氨酸蛋白酶、糖原合酶、金属蛋白酶、成熟酶、L-氨基酸氧化酶、纤溶酶源激活物、外源凝集素、富含半胱氨酸分泌酶、去整合素、纤连蛋白结合蛋白、纤维蛋白原凝固抑制因子A、血管凋亡诱导蛋白1、氨甲酰基磷酸合成酶、吡喃糖－2-氧化酶以及ablomin， catrin， mucrofirase， pallabin， salmosin和triflin的同源蛋白。

objective to observe the protective effect of qiliqiangxin capsule in rabbit heart ventricle reconstitution of chronic heart failure.methods using the method of giving rabbit abdomen aorta half ligations to build the chronic heart failure model to observe qiliqiangxin capsule the effect to blood flow mechanics index,room wall thickness,heart exponent and heart ventricle reconstitution biochemistry index.results qiliqiangxin capsule could reduce effectively bp,lvsp,lvedp,t wave,improve room wall thickness and heart exponent,reduce angii and alt,all the paramenters ahd notable difference,composed to those of model group (p＜0.05,p＜0.01).conclusion qiliqiangxin capsule can improve the blood flow mechanics change of chronic heart failure rabbit,which has notable inhibitory action on heart ventricle reconstitution which originate from chronic heart failure.inhibition of ang ii,alt of immune nerve endocrine system may be a mechanism of qiliqiangxin capsule.

观察血流动力学、标志心室重构的室壁厚度及心脏指数及肾素―血管紧张素―醛固酮系统相关生化指标的变化。结果芪苈强心胶囊可有效降低血压、左室压、左室末期舒张压、t波，改善室壁厚度和心脏指数，降低血清血管紧张素ii及醛固酮水平，与模型组比较均有显著性差异(p＜0.05，p＜0.01)。结论芪苈强心胶囊可改善慢性心力衰竭兔血流动力学的变化，对慢性心力衰竭引起的心室重构具有显著抑制作用，其机制可能与该药发挥抑制神经内分泌免疫系统rass中angii、ald的水平有关。

But we don't care about Battlegrounds.

但我们并不在乎沙场中的显露。

Ah! don't mention it, the butcher's shop is a horror.

啊！不用提了。提到肉，真是糟透了。