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Result: The series of Muskone decreased arterial blood pressure significantly, dilated coronary artery and peripheral arteries significantly, increased coronary blood flow, decreased resistance in coronary artery, improved the work of left artrium, the oxygen availability of cardiac muscles and the complaisance of arteries in cardiac muscles.

结果:冠心苏合丸系列组方可明显降低动脉血压,扩张冠脉血管及外周血管,增加冠脉流量,降低冠脉阻力;改善左室做功和心肌氧利用率,调整心脏血管的顺应性。结论:对心血管系统起到调整和改善作用。

The topical application of tanshinone IIA at one μg/ml and five μg/ml caused significant dose-related vasodilation, indicated by the increased agent/control ratio of arteriolar diameters from 1.0 to 1.25±0.08 and 1.57±0.11, respectively, in the hamster cheek pouch.

研究人员同时发现丹参酮IIA通过增加内皮表达一氧化氮合酶扩张金仓鼠颊囊小动脉,局部应用1μg/ml和5μg/ml的丹参酮IIA可引起血管舒张,具有明显剂量相关性——处理组/对照组金仓鼠颊囊小动脉内径分别由1.0扩张到1.25±0.08 和 1.57±0.11。

The topical application of tanshinone IIA at one μg/ml and fie μg/ml caused significant dose-related asodilation, indicated by the increased agent/control ratio of arteriolar diameters from 1.0 to 1.25±0.08 and 1.57±0.11, respectiely, in the hamster cheek pouch.

研究人员同时发现丹参酮IIA通过增加内皮表达一氧化氮合酶扩张金仓鼠颊囊小动脉,局部应用1μg/ml和5μg/ml的丹参酮IIA可引起血管舒张,具有明显剂量相关性——处理组/对照组金仓鼠颊囊小动脉内径分别由1.0扩张到1.25±0.08 和 1.57±0.11。

The embryonic vessels failed to invade into the labyrinthine layer of placenta, which impaired the embryonic-maternal vascular connection. These defects could not be rescued by wild-type tetraploid blastocysts, excluding the possibility that they were due to the extraembryonic tissues.

组织免疫组化分析结果显示:毛细血管腔异常扩张,排列紊乱,不能形成大血管及细致有序的血管网络;胚外中胚层来源的卵黄囊脏层扁平上皮细胞形态变圆,与内皮细胞连接受损;胚胎血管不能侵入胎盘迷路层,胚体与母体血管连接受损。

From the perfusion experiments with isolated rabbit heart and vessels were obtained the follow- ing results:(1)Potassium antimony tartrate produced depression of the isolated rabbit heart,and this depressant action became more marked when the pH of the solution was raised from the original value of 5.4 to that of 7.2;(2)At the same pH levels,the cardiac action of the potassium salt was slightly stronger than that of the corresponding sodium salt;(3)The slight vase-dilator effect of potass- ium anti...

从离体器官的灌注实验得到下列结果:(1)酒石酸锑钾对离体兎心有抑制作用,将其pH 从5.4调整到7.2时,作用亦随以增加。(2)在相同 pH 时,酒石酸锑钾的心臓抑制作用较酒石酸锑钠略强。(3)酒石酸锑钾对离体兎耳血管的轻微扩张作用,系由于该药溶液的微酸性反应,当将药液 pH 调整至7后即无作用。(4)对于离体兎肺血管则不问 pH 为4.8或7,均产生轻微的血管收缩作用。

There were high density images shaped as rope and slip in lungs of model control group rats and the pleura near the images were a little thickening. In MTX treated group, there were high density images shaped as slice along pulmonary veins. The veins of the blood vessels were obscure and the edges were unclear. In TPT treated group,there were multiple high density images shaped as tubercle and slice and the boundary were not clear. In XFC treated group, the lungs' outlines were clear and the veins were welldistributed. High density images shaped as spot were found in part lungs.

结果:HRCT表现为模型对照组大鼠肺轮廓欠清晰,肺部血管影扩张,边缘模糊且不规则,两肺有索条状密度增高影,邻近胸膜轻度肥厚;甲氨喋呤组大鼠肺部可见沿着肺纹理分布的斑片状密度增高影,肺血管纹理模糊,边缘不清楚;雷公藤多苷片组大鼠两肺可见多发性结节状及斑片状密度增高影,境界欠清晰;新风胶囊组大鼠肺轮廓清晰,肺纹理分布均匀,部分肺组织显示斑点状密度增高影。

Background:The recent studies showed specific physiology protection mechanism of premanopausal women. The endogenous estrogen of physiology level in their bodies was helpful to regulate lipid metabolism , provent and delay artherosclerosis , protect blood vessel endothelium , inhibit vascular smooth muscle hyperplasing , dilat blood vessel , degrade angiotasis , improve blood rheology , improve insulin resistance , raise survival rate and quality of life of premanopausal women patients with coronary heart disease .

背景:目前研究显示由于绝经前女性特有的生理保护机制,其体内生理水平的内源性雌激素有助于调整脂质代谢,防止和延缓动脉粥样硬化,保护血管内皮,抑制血管平滑肌增殖,扩张血管,降低血管张力,改善血液流变学,改善胰岛素抵抗,提高绝经前女性冠心病患者生存率和生活质量。

Postmenopausal women had lower aerobic capacity compared with premenopausal women and age-matched males, which may correlate with endothelial dysfunction, impaired functional sympatholysis, and insufficient muscular oxygenation. Exercise capacity is associated with cardiovascular risk factors, such as lipid profile, C-reactive protein, and body mass index.

与停经前女性或同龄男性相比,停经后女性的有氧耐力明显减少,运动时的血管内皮扩张反应与功能性抗交感反应下降,使周边血管在运动时扩张能力较差、肌肉血流与含氧量低,均是导致运动能力下降的因素。

ET and NO are the biology regulatory factors produced by vascular endothelial cell.ET is a peptide with vasoconstrictive and vasodilator effect produced by endothelial cells,and NO as a powerful endothelium-derived relaxing factor,has a strong role in dilation of blood vessels.

ET和NO是血管内皮细胞产生的生物调节因子,ET是由内皮细胞产生的一种多肽,具有缩血管和扩血管作用,而NO为一种强有力的血管内皮细胞舒张因子,具有强烈扩张血管作用。

This, in turn, trapped in cold water for physical contact when the skin vasoconstriction, blood pressure increased slightly, only a very short time; soon surface on the re-expansion of blood vessels, a large number of vascular blood flow to the skin, the blood pressure at this time, it has not been exposed to cold water than also slightly more.

这又困为身体接触冷水时表皮血管收缩,血压略微升高,只是很短暂的时间;很快表皮的血管就再度扩张,大量血液流向皮肤的血管,这时的血压,就反而比未接触冷水时还稍低些。

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